Exam 8: T Cell-Mediated Immunity

The etiological agent responsible for leprosy is Mycobacterium leprae,which survives and replicates within the vesicular system of macrophages.Explain the difference between tuberculoid leprosy and lepromatous leprosy in the context of T-cell differentiation and effector function.

(Essay)

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Question 21

Macrophages exhibit all of the following characteristics except _____.

(Multiple Choice)

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Question 22

Naive lymphocytes homing to lymphoid tissue use _____ to bind to CD34 and GlyCAM-1 on high endothelial venules.

(Multiple Choice)

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Question 23

Explain what feature of B cells makes them useful as professional antigen-presenting cells in an immune response.

(Essay)

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Question 24

Identify the mismatched pair.

(Multiple Choice)

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Question 25

Fos,a component of the transcription factor AP-1,is activated during T-cell signaling by a process involving a GTP-binding protein called _____.

(Multiple Choice)

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Question 26

Which of the following characteristics permits activated CD8 T cells to destroy any cell type harboring viable and replicating pathogens such as viruses?

(Multiple Choice)

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Question 27

Why are dendritic cells so important in adaptive immune responses? Explain what they do.

(Essay)

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Question 28

_____ is a second messenger in the T-cell signaling pathway leading to the activation of NFAT.

(Multiple Choice)

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Question 29

In a person with lepromatous leprosy,the lesions would contain mRNA for _____.

(Multiple Choice)

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Question 30

Which of the following is a feature of regulatory T cells (T_reg)? (Select all that apply.)

(Multiple Choice)

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Question 31

Which of the following is produced by CD8 T cells?

(Multiple Choice)

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Question 32

A.Explain the functional differences between immature and mature dendritic cells. B.Discuss why you think these functional changes should occur.

(Essay)

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Question 33

If a non-professional antigen-presenting cell that lacks co-stimulatory molecules presents peptide:MHC complexes to a T cell specific for that peptide,then _____.

(Multiple Choice)

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Question 34

The area of contact between membranes of a T cell and an antigen-presenting cell where a clustering of protein-protein interactions occur is called a(n)

(Multiple Choice)

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Question 35

IL-4 is induced in a CD4 T_H2 cell under the direction of the transcription factor _____.

(Multiple Choice)

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Question 36

Match the term with its counterpart.

signal transducers and activators of transcription (STATs)

a receptor on macrophages that facilitates killing of intravesicular bacteria

CD40

on cytoplasmic tails of CD3 proteins used for transmitting activation signals

VLA-4

when phosphorylated, it translocates as a dimer to the nucleus and facilitates expression of target genes

Correct Answer:

Verified

signal transducers and activators of transcription (STATs)

CD40

VLA-4

immunological synapse

immunoreceptor tyrosine-based activation motifs (ITAMs)

(Matching)

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Question 37

Activated T cells express _,which binds to B7 with 20 times higher affinity than CD28 and results in _ of T-cell activity and proliferation.

(Multiple Choice)

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Question 38

All of the following statements refer to regulatory T cells except ____.

(Multiple Choice)

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Question 39

All of the following are correctly matched except _____.

(Multiple Choice)

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Question 40

The etiological agent responsible for leprosy is Mycobacterium leprae,which survives and replicates within the vesicular system of macrophages.Explain the difference between tuberculoid leprosy and lepromatous leprosy in the context of T-cell differentiation and effector function.

Macrophages exhibit all of the following characteristics except _____.

Naive lymphocytes homing to lymphoid tissue use _____ to bind to CD34 and GlyCAM-1 on high endothelial venules.

Explain what feature of B cells makes them useful as professional antigen-presenting cells in an immune response.

Identify the mismatched pair.

Fos,a component of the transcription factor AP-1,is activated during T-cell signaling by a process involving a GTP-binding protein called _____.

Which of the following characteristics permits activated CD8 T cells to destroy any cell type harboring viable and replicating pathogens such as viruses?

Why are dendritic cells so important in adaptive immune responses? Explain what they do.

_____ is a second messenger in the T-cell signaling pathway leading to the activation of NFAT.

In a person with lepromatous leprosy,the lesions would contain mRNA for _____.

Which of the following is a feature of regulatory T cells (T_reg)? (Select all that apply.)

Which of the following is produced by CD8 T cells?

A.Explain the functional differences between immature and mature dendritic cells. B.Discuss why you think these functional changes should occur.

If a non-professional antigen-presenting cell that lacks co-stimulatory molecules presents peptide:MHC complexes to a T cell specific for that peptide,then _____.

The area of contact between membranes of a T cell and an antigen-presenting cell where a clustering of protein-protein interactions occur is called a(n)

IL-4 is induced in a CD4 T_H2 cell under the direction of the transcription factor _____.

Activated T cells express _,which binds to B7 with 20 times higher affinity than CD28 and results in _ of T-cell activity and proliferation.

All of the following statements refer to regulatory T cells except ____.

All of the following are correctly matched except _____.

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

Exam 8: T Cell-Mediated Immunity

The etiological agent responsible for leprosy is Mycobacterium leprae,which survives and replicates within the vesicular system of macrophages.Explain the difference between tuberculoid leprosy and lepromatous leprosy in the context of T-cell differentiation and effector function.

Macrophages exhibit all of the following characteristics except _____.

Naive lymphocytes homing to lymphoid tissue use _____ to bind to CD34 and GlyCAM-1 on high endothelial venules.

Explain what feature of B cells makes them useful as professional antigen-presenting cells in an immune response.

Identify the mismatched pair.

Fos,a component of the transcription factor AP-1,is activated during T-cell signaling by a process involving a GTP-binding protein called _____.

Which of the following characteristics permits activated CD8 T cells to destroy any cell type harboring viable and replicating pathogens such as viruses?

Why are dendritic cells so important in adaptive immune responses? Explain what they do.

_____ is a second messenger in the T-cell signaling pathway leading to the activation of NFAT.

In a person with lepromatous leprosy,the lesions would contain mRNA for _____.

Which of the following is a feature of regulatory T cells (Treg)? (Select all that apply.)

Which of the following is produced by CD8 T cells?

A.Explain the functional differences between immature and mature dendritic cells. B.Discuss why you think these functional changes should occur.

If a non-professional antigen-presenting cell that lacks co-stimulatory molecules presents peptide:MHC complexes to a T cell specific for that peptide,then _____.

The area of contact between membranes of a T cell and an antigen-presenting cell where a clustering of protein-protein interactions occur is called a(n)

IL-4 is induced in a CD4 TH2 cell under the direction of the transcription factor _____.

Activated T cells express _____,which binds to B7 with 20 times higher affinity than CD28 and results in _____ of T-cell activity and proliferation.

All of the following statements refer to regulatory T cells except ____.

All of the following are correctly matched except _____.

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

Which of the following is a feature of regulatory T cells (T_reg)? (Select all that apply.)

IL-4 is induced in a CD4 T_H2 cell under the direction of the transcription factor _____.

Activated T cells express _,which binds to B7 with 20 times higher affinity than CD28 and results in _ of T-cell activity and proliferation.