Question 1

Which of the following is most likely to produce a chromosomal inversion?

Accepted Answer

A)  aneuploidy 
B)  one double-strand breakage on each of two different chromosomes 
C)  transposition of a retrotransposon 
D)  double-strand breakage at two positions on the same chromosomes 
E)  Robertsonian translocation 
A)  aneuploidy 
B)  one double-strand breakage on each of two different chromosomes 
C)  transposition of a retrotransposon 
D)  double-strand breakage at two positions on the same chromosomes 
E)  Robertsonian translocation

Question 2

Despite selection against chromosomal variations

Accepted Answer

A)  related species almost always have the same karyotype. 
B)  total DNA content varies widely between individuals within the same species. 
C)  closely related species diverge by many chromosomal rearrangements. 
D)  distantly related species diverge by only a few chromosomal rearrangements. 
E)  related species almost always have a different karyotype. 
A)  related species almost always have the same karyotype. 
B)  total DNA content varies widely between individuals within the same species. 
C)  closely related species diverge by many chromosomal rearrangements. 
D)  distantly related species diverge by only a few chromosomal rearrangements. 
E)  related species almost always have a different karyotype.

Question 3

In terms of evolution,what is the most significant outcome of translocation in a species' genome?

Accepted Answer

A)  production of gene families 
B)  development of two species due to reproductive isolation 
C)  eventual extinction due to semisterility 
D)  Down syndrome 
E)  Klinefelter syndrome 
A)  production of gene families 
B)  development of two species due to reproductive isolation 
C)  eventual extinction due to semisterility 
D)  Down syndrome 
E)  Klinefelter syndrome

Question 4

Of the following segregation patterns,which one is most likely to result in a normal zygote?

Accepted Answer

A)  alternate 
B)  adjacent-1 
C)  adjacent-2 
D)  nondisjunction 
E)  triploid 
A)  alternate 
B)  adjacent-1 
C)  adjacent-2 
D)  nondisjunction 
E)  triploid

Question 5

What are LINEs and SINEs?

Accepted Answer

LINEs are long interspersed elements and

Question 6

Which of the following does not happen when an intragenic inversion occurs?

Accepted Answer

A)  One part of the gene is relocated to a distant region of the chromosome. 
B)  One part of the gene stays at its original site. 
C)  One part of the gene is relocated to another chromosome. 
D)  The gene's function remains unaffected. 
E)  The length of the chromosome remains unaffected. 
A)  One part of the gene is relocated to a distant region of the chromosome. 
B)  One part of the gene stays at its original site. 
C)  One part of the gene is relocated to another chromosome. 
D)  The gene's function remains unaffected. 
E)  The length of the chromosome remains unaffected.

Question 7

Explain how data from the linkage groups of the mouse can be used as a resource for assessing human linkage groups.

Accepted Answer

Because virtually all genes cloned from

Question 8

We now know that several organisms have a high degree of synteny at the genomic level.You wish to test the hypothesis that the laboratory mouse and humans share genomic similarities.What tests would you complete and given that we now know that the mouse and human genomes are highly syntenic,what results would you expect?

Accepted Answer

Karyotype analysis can be used to test t

Question 9

An acentric fragment is an inversion crossover product lacking a centromere.

Accepted Answer

A) True 
 B)False

Question 10

What are the possible effects of transposable elements on gene function,and how do these relate to evolution?

Accepted Answer

The insertion of a transposable element

Question 11

Which of the following sex chromosome aneuploidies is not usually seen in live births?

Accepted Answer

A)  XO 
B)  XXY 
C)  YO 
D)  XXX 
E)  None of the choices are correct. 
A)  XO 
B)  XXY 
C)  YO 
D)  XXX 
E)  None of the choices are correct.

Question 12

A hallmark of transposons is that their ends are inverted repeats of each other.

Accepted Answer

A) True 
 B)False

Question 13

The genus Triticale is a new genus of the various allopolyploid hybrids between wheat and rye.Some of the members of this genus show agricultural promise because

Accepted Answer

A)  wheat has a high yield. 
B)  rye adapts well to unfavorable environments. 
C)  wheat has a high level of protein. 
D)  rye has a high level of lysine. 
E)  All of the choices are correct. 
A)  wheat has a high yield. 
B)  rye adapts well to unfavorable environments. 
C)  wheat has a high level of protein. 
D)  rye has a high level of lysine. 
E)  All of the choices are correct.

Question 14

Turner syndrome,XO,is a sex chromosome aneuploidy.Of the effects listed below,which one is not usually seen in this syndrome?

Accepted Answer

A)  unusually short stature 
B)  infertility 
C)  skeletal abnormalities 
D)  unusually long limbs 
E)  abnormal karyotype 
A)  unusually short stature 
B)  infertility 
C)  skeletal abnormalities 
D)  unusually long limbs 
E)  abnormal karyotype

Question 15

The various types of transposable elements have many things in common.Which of the following is not a usual characteristic of them?

Accepted Answer

A)  larger than 50 kb 
B)  may be present in a genome from one to thousands of times 
C)  found only in a select group of organisms 
D)  need not be sequences that do something for the organism 
E)  can alter gene expression 
A)  larger than 50 kb 
B)  may be present in a genome from one to thousands of times 
C)  found only in a select group of organisms 
D)  need not be sequences that do something for the organism 
E)  can alter gene expression

Question 16

Which of the following would be most difficult to identify by comparative genomic hybridization (CGH)?

Accepted Answer

A)  duplication 
B)  deletion 
C)  monosomy 
D)  base substitution 
E)  trisomy 
A)  duplication 
B)  deletion 
C)  monosomy 
D)  base substitution 
E)  trisomy

Question 17

Explain the differences between chromosomal rearrangements and changes in chromosome number.Cite at least one example of each.

Accepted Answer

Chromosomal rearrangements reorganize th

Question 18

In general,which of the following usually has a greater chance of lethality than the others?

Accepted Answer

A)  inversion 
B)  duplication 
C)  deletion 
D)  translocation 
E)  transcription 
A)  inversion 
B)  duplication 
C)  deletion 
D)  translocation 
E)  transcription

Question 19

During the pairing of homologues in prophase of meiosis I,the region of a normal,nondeleted chromosome that has nothing with which to recombine forms a so-called

Accepted Answer

A)  inversion loop. 
B)  deletion heterozygote. 
C)  crossover suppressor. 
D)  D loop. 
E)  deletion loop. 
A)  inversion loop. 
B)  deletion heterozygote. 
C)  crossover suppressor. 
D)  D loop. 
E)  deletion loop.

Question 20

In Drosophila,a gynandromorph,which is composed of equal parts of male and female tissue,results from

Accepted Answer

A)  an XX female losing one X chromosome during the first mitotic division after fertilization. 
B)  an egg carrying an X chromosome fertilized by a Y-carrying sperm. 
C)  a normal egg fertilized by both an X-carrying sperm and a Y-carrying sperm. 
D)  the fusion of a female embryo with a male embryo. 
E)  the fusion of a female egg by an XX sperm. 
A)  an XX female losing one X chromosome during the first mitotic division after fertilization. 
B)  an egg carrying an X chromosome fertilized by a Y-carrying sperm. 
C)  a normal egg fertilized by both an X-carrying sperm and a Y-carrying sperm. 
D)  the fusion of a female embryo with a male embryo. 
E)  the fusion of a female egg by an XX sperm.

Exam 8: Digital Analysis of Genomes

Which of the following is most likely to produce a chromosomal inversion?

Despite selection against chromosomal variations

In terms of evolution,what is the most significant outcome of translocation in a species' genome?

Of the following segregation patterns,which one is most likely to result in a normal zygote?

What are LINEs and SINEs?

Which of the following does not happen when an intragenic inversion occurs?

Explain how data from the linkage groups of the mouse can be used as a resource for assessing human linkage groups.

An acentric fragment is an inversion crossover product lacking a centromere.

What are the possible effects of transposable elements on gene function,and how do these relate to evolution?

Which of the following sex chromosome aneuploidies is not usually seen in live births?

A hallmark of transposons is that their ends are inverted repeats of each other.

The genus Triticale is a new genus of the various allopolyploid hybrids between wheat and rye.Some of the members of this genus show agricultural promise because

Turner syndrome,XO,is a sex chromosome aneuploidy.Of the effects listed below,which one is not usually seen in this syndrome?

The various types of transposable elements have many things in common.Which of the following is not a usual characteristic of them?

Which of the following would be most difficult to identify by comparative genomic hybridization (CGH)?

Explain the differences between chromosomal rearrangements and changes in chromosome number.Cite at least one example of each.

In general,which of the following usually has a greater chance of lethality than the others?

During the pairing of homologues in prophase of meiosis I,the region of a normal,nondeleted chromosome that has nothing with which to recombine forms a so-called

In Drosophila,a gynandromorph,which is composed of equal parts of male and female tissue,results from

Mendels Principles of Heredity

Extensions to Mendels Laws

The Chromosome Theory of Inheritance

Linkage, Recombination, and the Mapping of Genes on Chromosomes

Dna Structure, Replication, and Recombination

Anatomy and Function of a Gene: Dissection Through Mutation

Gene Expression: the Flow of Information From Dna to Rna to Protein

Genome Annotation

Analyzing Genomic Variation

The Eukaryotic Chromosome

Chromosomal Rearrangements and Changes in Chromosome Number

Bacterial Genetics

Organellar Inheritance

Gene Regulation in Prokaryotes

Gene Regulation in Eukaryotes

Manipulating the Genomes of Eukaryotes

The Genetic Analysis of Development

The Genetics of Cancer

Variation and Selection in Populations

Genetics of Complex Traits

Exploring Synthetic Biology: Concepts, Techniques, and Applications

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