Deck 16: Transplantation Immunology

Question 1

A transplant patient on a follow-up visit to his physician is noted to have progressive fibrosis and scarring with narrowing of the vessels leading to the transplanted organ.What type of rejection is occurring?

A) Hyperacute
B) Acute
C) Chronic
D) Accelerated

Answer 1

Chronic

Question 2

A transplant patient has been prescribed corticosteroids as part of his post-transplant medication regimen.What class of drug is the patient taking?

A) Hormone
B) Immunosuppressive
C) Anti-metabolite
D) Calcineurin inhibitor

Answer 2

Immunosuppressive

Question 3

A patient undergoes a skin graft from the back to cover a damaged area on the neck.This is an example of what type of transplant?

A) Heterograft
B) Xenograft
C) Allograft
D) Autograft

Answer 3

Autograft

Question 4

The percent (%)panel reactive antibody (%PRA)is the proportion of lymphocytes in the panel killed by the patient's serum and complement.

Question 5

To determine a patient's HLA type using the complement-dependent cytotoxicity test,which of the following must be used?

A) Viable lymphocytes
B) Purified T cells
C) A single antiserum from a commercial source
D) Complement from patient serum

Question 6

Which histocompatibility system activates gamma or delta T-cell receptors?

A) ABO blood group antigen
B) Killer immunoglobulin-like receptors
C) MHC class-I related chain A (MICA) antigen
D) Minor histocompatibility antigens

Question 7

Four candidate bone-marrow donors were tested for compatibility with a patient in need of a transplant.HLA typing was performed,and the serologic types and alleles of the patient and four potential donors are shown in the table.On the basis of these findings,which donor would be the best match for the patient?

A) Donor 1
B) Donor 2
C) Donor 3
D) Donor 4

Question 8

The type of allograft rejection associated with fibrosis and scarring of vessel lumens is:

A) a hyperacute rejection.
B) an acute antibody-mediated rejection.
C) an acute cellular rejection.
D) a chronic rejection.

Question 9

To correctly read a complement-dependent cytotoxicity test,the technologist should record the number of viable cells.

Question 10

To determine whether a patient can accept a solid organ transplant from a nonrelated donor,which of the following tests would be used to verify compatibility after an HLA match is determined?

A) ABO blood typing
B) CDC assay
C) HLA antibody screen
D) RAST test

Question 11

In direct allorecognition,the recipient T cells bind and respond directly to foreign HLA proteins.

Question 12

In indirect allorecognition,the host's T helper cells recognize foreign protein and uptake,process,and present it to recipient antigen-presenting cells (APCs).

Question 13

In a patient who is exhibiting signs of graft-versus-host disease,which cell type is most likely responsible for the reaction?

A) B cells
B) T cells
C) Macrophages
D) Eosinophils

Question 14

A transplantation patient suffers an organ rejection within hours after the procedure.What type of rejection occurred?

A) Hyperacute
B) Acute
C) Chronic
D) Graft-versus-host disease

Question 15

Which of the following is characteristic of an acute graft-versus-host disease episode?

A) The reaction occurs within 100 days of the transplant.
B) The reaction involves the skin, gastrointestinal (GI) tract, and liver.
C) The reaction produces a fibrous condition of the mouth and eyes.
D) The reaction involves the recipient's bone marrow.

Question 16

Suppose a mother and her child possess the following HLA haplotypes:?Mother: ?A28 B17 Cw4 Dw3?A30 B21 Cw2 Dw10?Child: ?A3 B8 Cw6 Dw7?A28 B17 Cw4 Dw3 Paternity testing was performed.Three potential fathers were HLA typed and found to contain the following haplotypes:?Father 1: ?A30 B21 Cw2 Dw10?A1 B2 Cw5 Dw9?Father 2: ?A3 B8 Cw6 Dw7?A8 B9 Cw1 Dw8?Father 3: ?A3 B8 Cw5 Dw4?A2 B1 Cw6 Dw7??Which of the following statements is true?

A) The true father may be Father 1 only.
B) The true father may be Father 2 only.
C) The true father may be Father 1 or Father 2.
D) The true father may be Father 2 or Father 3.