Deck 14: The Myelodysplastic Syndromes

Question 1

All of the following are dysplastic changes of platelets frequently seen in MDS except:

A)Abnormal granulation
B)Micromega karyocytes
C)Giant platelets
D)Platelet satellitism

Answer 1

D

Question 2

The bone marrow and peripheral smear of a patient with an MDS will show dysplastic changes in _____ over time.

A)white blood cells
B)red blood cells
C)platelets
D)All of the above

Answer 2

D

Question 3

All of the following are features of the myelodysplastic syndromes except:

A)Anemia
B)Organomegaly
C)Dysplasia
D)Hypercellular marrow

Answer 3

B

Question 4

The blast count in most individuals with MDS is less than:

A)10%
B)40%
C)5%
D)20%

Question 5

A major concern for the management of patients with MDSs is iron overload.

Question 6

The most common hematological malignancy in the adult population is:

A)Acute leukemia
B)Multiple myeloma
C)Myelodysplastic syndrome
D)Chronic leukemias

Question 7

Deleted 5q MDS is primarily seen in male patients.

Question 8

Typically, patients with MDS will exhibit partial or complete absence of:

A)Chromosomes 5 and 7
B)Chromosomes 8 and 12
C)The Y chromosome
D)Dysplasia

Question 9

A large percentage of the MDSs end in an acute leukemia.

Question 10

Reticulocytopenia is a feature of MDS.Which one of the following is the mechanism behind this process?

A)Heavy tumor burden
B)Marrow aplasia
C)Ineffective erythropoiesis
D)Toxic effects

Question 11

Which of the following bone marrow blast percentages will be consistent with the FAB classification of refractory anemia with excess of blasts (RAEB)?

A)5% to 20%
B)20% to 30%
C)Greater than 30%
D)Less than 5%

Question 12

All of the following are associated with the development of the MDSs except:

A)Alkylating therapy
B)Benzene exposure
C)Alcoholism
D)Radiation

Question 13

The most effective means of treating iron overload in the myelodysplastic syndromes is:

A)Therapeutic phlebotomy
B)Limiting iron-containing foods
C)Iron chelation therapy
D)Fasting

Question 14

One of the key white cell features in MDS is:

A)Hypersegmented neutrophils
B)Auer rods
C)Döhle bodies
D)Pseudo-Pelger-Huët

Question 15

Which of the following chromosome disorders in MDS has a poor predictive influence?

A)Chromosome 7 disorder
B)Trisomy 12
C)Trisomy 13
D)17q deletion

Question 16

The morphological classification of anemia in the myelodysplastic syndromes is:

A)Normocytic, normochromic
B)Microcytic, hypochromic
C)Macrocytic, normochromic
D)Microcytic, normochromic

Question 17

Refractory anemia is an anemia that:

A)Has more than 5% blasts in the peripheral blood
B)Is resistant to treatment
C)Will usually demonstrate a hypoplastic bone marrow
D)Demonstrates a 17q deletion routinely