Deck 11: Acute Leukemias

Question 1

The monoclonal marker that is often positive in T-ALL is:

A)CD1
B)CD7
C)CD10
D)CD41

Answer 1

B

Question 2

Migration to extramedullary sites is a feature of which of the following leukemias?

A)Acute progranulocytic leukemia
B)Acute myelocytic leukemia
C)Acute monocytic leukemia
D)Acute lymphocytic leukemia

Answer 2

C

Question 3

A patient presents with generalized lymphadenopathy and a WBC of 100 $\times$ 10⁹/L.This hematologic picture would most likely be seen in:

A)Chronic lymphocytic leukemia
B)Acute lymphocytic leukemia
C)Burkitt's lymphoma
D)Hairy cell leukemia

Answer 3

Chronic lymphocytic leukemia

Question 4

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14- and CD4-positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

A)ALL
B)AMonoL
C)AMML
D)AML

Question 5

The translocation t(15:17)(q22;q12) is associated with which of the following leukemias?

A)Acute promyelocytic leukemia
B)Acute myelomonocytic leukemia
C)Acute lymphocytic leukemia
D)Acute myelocytic leukemia

Question 6

The leukemia with a predominance of WBC cells positive for CD41 is:

A)AMML
B)AML
C)AMonoL
D)AMegL

Question 7

Acute leukemic processes are marked by:

A)Slow onset, slow progression, anemia
B)Rapid onset anemia, thrombocytopenia
C)Splenomegaly
D)Less than 30% in the BM

Question 8

_____ is predominantly a disease of children.

A)AML
B)CML
C)ALL
D)CLL

Question 9

Greater than ______ of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

A)10%
B)20%
C)25%
D)30%

Question 10

The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:

A)Replacement of normal marrow precursors by leukemic cells
B)Decrease in functional leukocytes causing infection
C)Hemorrhage secondary to thrombocytopenia
D)Decreased erythropoietin production

Question 11

Pure erythroid leukemia is defined as:

A)Erythroid precursors greater than 30%, myeloblasts less than 20%
B)Erythroid precursors greater than 50%, myeloblasts less than 40%
C)Erythroid precursors less than 50%
D)Erythroid precursors greater than 80%

Question 12

Pediatric patients with ALL have an overall complete remission rate of:

A)50%
B)65%
C)75%
D)85%

Question 13

Which CD marker best represents the earliest progenitor cells?

A)CD11
B)CD19
C)CD34
D)CD57

Question 14

A patient with AML is likely to have a cytochemical stain panel that is positive for:

A)Sodium fluoride with tartrate resistance
B)MPO, SBB, specific esterase
C)MP0, SBB, nonspecific esterase
D)SBB and TdT

Question 15

Which of the following is characteristic of Auer rods?

A)Composed of fused primary granules
B)Predominantly seen in ALL
C)Predominantly seen in HCL
D)Composed of specific granules

Question 16

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

A)Hypercellular bone marrow with greater than 20% blasts
B)Hypercellular bone marrow with less than 20% blasts
C)Hypocellular bone marrow with greater than 20% blasts
D)Hypocellular bone marrow with less than 20% blasts