Deck 2: From Hematopoiesis to the Complete Blood Count

Question 1

The CFU-GEMM is a multipotential stem cell, capable of differentiating into a lymphoid or nonlymphoid precursor committed cell.

Answer 1

False

Question 2

Erythropoietin is produced by the:

A)Kidneys
B)Liver
C)Spleen
D)Thymus gland

Answer 2

A

Question 3

All of the following splenic functions are related to hematopoiesis, except:

A)Production of opsonizing antibodies
B)Production of WBCS, if necessary
C)Filtering out of old or deformed cells
D)Storage of platelets and granulocytes

Answer 3

A

Question 4

The ______ is one of the most stable parameters in a CBC.

A)MCV
B)Hct
C)MCHC
D)MCH

Question 5

The hormone responsible for red blood cell development in the bone marrow is:

A)Thyroxin
B)Insulin
C)Leukopoietin
D)Erythropoietin

Question 6

Which of the following is a site of extramedullary hematopoiesis in an adult?

A)Spleen
B)Liver
C)Iliac crest
D)Both A and B

Question 7

Which of the following sites is the most preferable for bone marrow aspiration and biopsy in adults?

A)Sternum
B)Iliac crest
C)Fibula
D)Vertebra

Question 8

What is the average M:E ratio for normal adult bone marrow?

A)1:3
B)4:1
C)1:4
D)6:1

Question 9

A patient with the following values-RBC = 4.01 $\times$ 10¹²/L, Hgb = 12.5 g/dL, and Hct = 37.2%-will most likely have which of the following RBC indices?

A)MCV = 92.8 fL, MCH = 31.2 pg, MCHC = 33.6%
B)MCV = 92.8 fL, MCH = 33.6 pg, MCHC = 31.2%
C)MCV = 107.8 fL, MCH = 32.1 pg, MCHC = 33.6%
D)MCV = 132.2 fL, MCH = 32.1 pg, MCHC = 33.5%

Question 10

A Wright-stained smear of a patient's bone marrow would effectively reveal all the following cells except:

A)Iron-containing cells
B)RBC precursor cells
C)WBC precursor cells
D)Mature WBCs

Question 11

The spleen harbors _____ of the circulatory platelet mass.

A)one-quarter
B)one-third
C)one-half
D)three-quarters

Question 12

Mature red blood cells leave the bone marrow and enter the circulation via the:

A)Reticuloendothelial system
B)Osteoclasts
C)Spleen
D)Bone marrow sinuses

Question 13

A patient's hemoglobin is 12.3 g/dL.On the peripheral smear, the red cells appear normochromic and normocytic.The hematocrit value that correlates with these data is:

A)34%
B)37%
C)40%
D)43%

Question 14

Which of these assays is the best test to assess the bone marrow's response to anemic stress?

A)Hemoglobin value
B)MCV value
C)Reticulocyte count
D)Hematocrit

Question 15

Which of the following is a primary site for hematopoiesis in a fetus of 4 to 5 months' gestation?

A)Yolk sac
B)Spleen
C)Distal long bones
D)Axial skeleton

Question 16

Bone marrow aspiration is usually required in conditions of:

A)Anemia
B)Hypoxia
C)Leukemia
D)Hepatosplenomegaly

Question 17

Patients with moderate anemias (7 to 10 g/dL) may be asymptomatic.

Question 18

The key organs involved in extramedullary hematopoiesis include the:

A)Kidney and thymus
B)Lymph nodes and heart
C)Liver and spleen
D)Kidney and liver

Question 19

The CBC parameter that gives insight into the amount of anisocytosis present in a specimen is:

A)RDW
B)MCHC
C)MCV
D)Hgb

Question 20

Opsonizing antibodies produced by the spleen serve to:

A)Strip the capsule from bacterial pathogens
B)Recycle erythrocyte byproducts
C)Aid in extramedullary hematopoiesis
D)Fight viral infection