Deck 4: Modifications of Mendelian Ratios
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Deck 4: Modifications of Mendelian Ratios
1
Assume that a dihybrid cross is made in which the genes' loci are autosomal,
independently assorting, and incompletely dominant. How many different phenotypes are expected in the offspring?
independently assorting, and incompletely dominant. How many different phenotypes are expected in the offspring?
9
2
With which of the following would hemizygosity most likely be associated?
A) sex -limited inheritance
B) incomplete dominance
C) X -linked inheritance
D) autosomal dominance
E) codominance
A) sex -limited inheritance
B) incomplete dominance
C) X -linked inheritance
D) autosomal dominance
E) codominance
C
3
Typical ratios resulting from epistatic interactions in dihybrid crosses would be
A) 1:2:2:4:1:2:1:2:1, 1:2:1
B) 3:1, 1:1
C) 1:1:1:1, 1:4:6:4:1
D) 9:3:4, 9:7
E) 9:3:3:1, 1:2:1
A) 1:2:2:4:1:2:1:2:1, 1:2:1
B) 3:1, 1:1
C) 1:1:1:1, 1:4:6:4:1
D) 9:3:4, 9:7
E) 9:3:3:1, 1:2:1
D
4
With incomplete dominance, a likely ratio resulting from a monohybrid cross would be ________.
A) 3:1
B) 1:2
C) 1:2:1
D) 9:3:3:1
E) 1:2:2:4
A) 3:1
B) 1:2
C) 1:2:1
D) 9:3:3:1
E) 1:2:2:4
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5
Because of the mechanism of sex determination, males of many species can be neither homozygous nor heterozygous. Such males are said to be _.
A) hemizygous
B) dominant
C) complementary
D) recessive
E) None of the answers listed is correct.
A) hemizygous
B) dominant
C) complementary
D) recessive
E) None of the answers listed is correct.
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6
A condition in which one gene pair masks the expression of a nonallelic gene pair is called
________.
A) epistasis
B) dominance
C) recessiveness
D) additive alleles
E) codominance
________.
A) epistasis
B) dominance
C) recessiveness
D) additive alleles
E) codominance
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7
Assume that a cross is made between two organisms that are both heterozygous for a gene that shows incomplete dominance. What phenotypic and genotypic ratios are
expected in the offspring?
expected in the offspring?
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8
The presence of more than two alternative forms of a given gene would be called
A) multiple alleles
B) alternation of generations
C) codominance
D) hemizygosity
E) incomplete dominance
A) multiple alleles
B) alternation of generations
C) codominance
D) hemizygosity
E) incomplete dominance
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9
Many of the color varieties of summer squash are determined by several interacting loci: AA or Aa gives white, aaBB or aaBb gives yellow, and aabb produces green.
Assume that two fully heterozygous plants are crossed. Give the phenotypes (with frequencies) of the offspring.
Assume that two fully heterozygous plants are crossed. Give the phenotypes (with frequencies) of the offspring.
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10
What is meant by the term epistasis? Distinguish between epistasis and dominance. Do not use examples in answering this question.
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11
The trait of medium -sized leaves in iris is determined by the genetic condition PP'. Plants with large leaves are PP, whereas plants with small leaves are P'P'. A cross is made between two plants each with medium -sized leaves. If they produce 80
seedlings, what would be the expected phenotypes, and in what numbers would they be expected? What is the term for this allelic relationship?
seedlings, what would be the expected phenotypes, and in what numbers would they be expected? What is the term for this allelic relationship?
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12
How many different alleles can a gene have?
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13
A mutation in a gene often results in a reduction of the product of that gene. The term for this type of mutation is _.
A) codominance
B) gain of function
C) incomplete dominance
D) loss of function or null (in the case of complete loss)
E) multiple allelism
A) codominance
B) gain of function
C) incomplete dominance
D) loss of function or null (in the case of complete loss)
E) multiple allelism
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14
The following coat colors are determined by alleles at one locus in horses: palomino = golden coat with lighter mane and tail
cremello = almost white chestnut = brown
The following table gives ratios obtained in matings of the above varieties:
Assign gene symbols for the genetic control of coat color on the basis of these data. Diagram the last two matings.
cremello = almost white chestnut = brown
The following table gives ratios obtained in matings of the above varieties:

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15
The trait for medium -sized leaves in iris is determined by the genetic condition PP'.
Plants with large leaves are PP, whereas plants with small leaves are P'P'. The trait for red flowers is controlled by the genes RR, pink by RR', and white by R'R'. A cross is
made between two plants each with medium -sized leaves and pink flowers. If they
produce 320 seedlings, what would be the expected phenotypes, and in what numbers would they be expected? Assume no linkage.
Plants with large leaves are PP, whereas plants with small leaves are P'P'. The trait for red flowers is controlled by the genes RR, pink by RR', and white by R'R'. A cross is
made between two plants each with medium -sized leaves and pink flowers. If they
produce 320 seedlings, what would be the expected phenotypes, and in what numbers would they be expected? Assume no linkage.
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16
Assume that a dihybrid cross (AaBb × AaBb) is made in which the gene loci are
autosomal, independently assorting, and incompletely dominant. What phenotypic
ratio would you expect from such a cross? Just provide the ratio, not the phenotypes.
autosomal, independently assorting, and incompletely dominant. What phenotypic
ratio would you expect from such a cross? Just provide the ratio, not the phenotypes.
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17
In a mating between individuals with the genotypes IAIB × IOI, what percentage of the offspring are expected to have the O blood type?
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18
In a mating between individuals with the genotypes IAIO × IOIO, what percentage of the offspring are expected to have the O blood type?
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19
The following F2 results occur from a typical dihybrid cross:
If a double heterozygote (AaBb) is crossed with a fully recessive organism (aabb), what phenotypic ratio is expected in the offspring?

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20
In the mouse, gene A allows pigmentation to be deposited in the individual coat hairs; its allele a prevents such deposition of pigment, resulting in an albino. Gene B gives
agouti (wild -type fur); its allele b gives black fur.
a() Diagram the cross between a doubly heterozygous agouti mouse mated with a doubly homozygous recessive white mouse.
b() What would be the expected phenotypic ratio in the progeny?
agouti (wild -type fur); its allele b gives black fur.
a() Diagram the cross between a doubly heterozygous agouti mouse mated with a doubly homozygous recessive white mouse.
b() What would be the expected phenotypic ratio in the progeny?
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21
Comb shape in chickens represents one of the classic examples of gene interaction. Two gene pairs interact to influence the shape of the comb. The genes for rose comb (R) and pea comb (P) together produce walnut comb. The fully homozygous recessive
condition (rrpp) produces the single comb. Assume that a rose -comb chicken is crossed with a walnut -comb chicken and the following offspring are produced: 17 walnut, 16 rose, 7 pea, 6 single.
a() What are the probable genotypes of the parents?
b() Give the genotypes of each of the offspring classes.
condition (rrpp) produces the single comb. Assume that a rose -comb chicken is crossed with a walnut -comb chicken and the following offspring are produced: 17 walnut, 16 rose, 7 pea, 6 single.
a() What are the probable genotypes of the parents?
b() Give the genotypes of each of the offspring classes.
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22
The genes for zeste eyes and forked bristles are located on the X chromosome in
Drosophila melanogaster. Both genes are recessive. A cross is made between a zeste -eyed female and a forked -bristled male.
a() If 200 offspring from this cross were obtained, present the expected number, sex, genotype, and phenotype in each class of the F1.
b() If the F1 offspring were crossed to produce 800 flies of an F2 generation, present the expected number, sex, and phenotype in each class. Assume no crossing over.
Drosophila melanogaster. Both genes are recessive. A cross is made between a zeste -eyed female and a forked -bristled male.
a() If 200 offspring from this cross were obtained, present the expected number, sex, genotype, and phenotype in each class of the F1.
b() If the F1 offspring were crossed to produce 800 flies of an F2 generation, present the expected number, sex, and phenotype in each class. Assume no crossing over.
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23
Many of the color varieties of summer squash are determined by several interacting
loci: AA or Aa gives white, aaBB or aaBb gives yellow, and aabb produces green. Crosses among heterozygotes give a 12:3:1 ratio. What type of gene interaction would account for these results?
loci: AA or Aa gives white, aaBB or aaBb gives yellow, and aabb produces green. Crosses among heterozygotes give a 12:3:1 ratio. What type of gene interaction would account for these results?
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24
What distinguishes sex -limited from sex -influenced inheritance?
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25
State a significant difference between X -linked and sex -influenced inheritance.
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26
Below is a pedigree of a fairly common human hereditary trait in which the boxes represent males and the circles represent females. Shading symbolizes the abnormal phenotype.
Given that one gene pair is involved:
a() Is the inheritance pattern X -linked or autosomal, recessive, or dominant?
b() Give the genotype of each individual in the pedigree. If more than one genotypic possibility exists, present all possible alternatives.

Given that one gene pair is involved:
a() Is the inheritance pattern X -linked or autosomal, recessive, or dominant?
b() Give the genotype of each individual in the pedigree. If more than one genotypic possibility exists, present all possible alternatives.

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27
Two forms of hemophilia are determined by genes on the X chromosome in humans. Assume that a phenotypically normal woman whose father had hemophilia is married to a normal man. What is the probability that their first daughter will have
hemophilia?
hemophilia?
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28
Assume that a dihybrid F2 ratio, resulting from epistasis, was 9:3:4. If a double
heterozygote is crossed with the fully recessive type, what phenotypic ratio is expected among the offspring?
heterozygote is crossed with the fully recessive type, what phenotypic ratio is expected among the offspring?
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29
A particular cross gives a modified dihybrid ratio of 9:7. What phenotypic ratio would you expect in a testcross of the fully heterozygous F1 crossed with the fully recessive
type? Diagram the testcross using A,a,B,b as symbol sets.
type? Diagram the testcross using A,a,B,b as symbol sets.
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30
A cross was made between homozygous wild -type female Drosophila and
yellow -bodied male Drosophila. All of the resulting offspring were phenotypically wild type. Offspring of the F2 generation had the following phenotypes:
Based on this information:
a() Is the mutant gene for yellow body behaving as a recessive or dominant gene?
b() Is the yellow locus on an autosome or on the X chromosome?
yellow -bodied male Drosophila. All of the resulting offspring were phenotypically wild type. Offspring of the F2 generation had the following phenotypes:

a() Is the mutant gene for yellow body behaving as a recessive or dominant gene?
b() Is the yellow locus on an autosome or on the X chromosome?
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31
If an X -linked disorder is lethal to the affected individual prior to the age at which one reaches reproductive maturation, the lethality will be expressed only in males. Why is this so?
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32
Regarding the ABO blood group system in humans, if an individual is genetically IBIO
and yet expresses the O blood type, which genotype is the individual likely to have?
and yet expresses the O blood type, which genotype is the individual likely to have?
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33
Assume that a dihybrid F2 ratio, resulting from epistasis, was 15:1. If a double
heterozygote is crossed with the fully recessive type, what phenotypic ratio is expected among the offspring?
heterozygote is crossed with the fully recessive type, what phenotypic ratio is expected among the offspring?
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34
Two forms of hemophilia are determined by genes on the X chromosome in humans. Assume that a phenotypically normal woman whose father had hemophilia is married to a normal man. What is the probability that their first son will have hemophilia?
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35
Which types of ratios are likely to occur in crosses (F2) when one is dealing with two interacting, epistatic gene pairs?
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36
Name three modes of inheritance that are influenced by the sex of individuals.
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37
Pattern baldness is determined by a single autosomal gene pair. When females are homozygous for this gene pair, can they show pattern baldness?
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38
The white -eye gene in Drosophila is recessive and sex -linked. Assume that a
white -eyed female is mated to a wild -type male. What would be the phenotypes of the offspring?
white -eyed female is mated to a wild -type male. What would be the phenotypes of the offspring?
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39
Provide an example of sex -influenced inheritance.
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40
The enzyme glucose -6 -phosphate dehydrogenase deficiency (G6PD) is inherited as a recessive gene on the X chromosome in humans. A phenotypically normal woman
(whose father had G6PD) is married to a normal man.
a() What fraction of their sons would be expected to have G6PD?
b() If the husband had G6PD, would it make a difference in your answer in part (a)?
(whose father had G6PD) is married to a normal man.
a() What fraction of their sons would be expected to have G6PD?
b() If the husband had G6PD, would it make a difference in your answer in part (a)?
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41
Penetrance specifically refers to the expression of lethal genes in heterozygotes.
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42
The term expressivity defines the percentage of individuals who show at least some degree of expression of a mutant genotype.
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43
Genomic anticipation refers to observations that a genetic disorder occurs at an earlier age in successive generations, whereas genetic imprinting occurs when gene expression varies depending on parental origin.
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44
A conditional mutant is one whose expression is influenced by some environmental condition.
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45
Alleles that are masked by an epistatic locus are said to be hypostatic to the genes at that locus.
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46
With both incomplete dominance and codominance, one expects heterozygous and homozygous classes to be phenotypically identical.
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47
Pattern baldness and hen/cock feathering in fowl are examples of X -linked inheritance.
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48
Hemizygosity is the term used to describe the state of a gene that has no allele on the opposing chromosome.
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49
The ABO blood group locus in humans provides an example of epistasis.
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50
Sex -limited inheritance is the same as sex -linked inheritance.
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51
A typical epistatic ratio is 9:3:4.
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52
A 9:7 ratio indicates incomplete dominance.
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53
Genomic imprinting occurs when one allele converts another.
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54
Assume that a mutation occurs in the gene responsible for the production of hexosaminidase A, such that only about 50 percent of the enzyme activity is found in the heterozygote compared with a homozygous normal individual. If heterozygotes are
phenotypically normal, we would say that the mutant allele is recessive to its normal allele.
phenotypically normal, we would say that the mutant allele is recessive to its normal allele.
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55
Expressivity is the term used to describe the balanced genetic output from a hemizygous condition.
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56
A maternal effect, or maternal influence, occurs when the offspring's phenotype is under the control of the mother's nuclear gene products that are present in the egg.
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57
One result of X -linkage is a crisscross pattern of inheritance in which sons
express recessive genes of their fathers and daughters express recessive genes of their mothers.
express recessive genes of their fathers and daughters express recessive genes of their mothers.
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58
With multiple alleles, there can be more than two genetic alternatives for a given locus.
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59
"Gain of function" mutations are generally dominant because one copy in a diploid organism is sufficient to alter the normal phenotype.
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