Deck 13: Pharmacokinetics: Absorption and Distribution

Question 1

Highly lipophilic substances can cross the blood-brain barrier.Which of the following cannot cross the blood-brain barrier in normal circumstances?

A) Alcohol
B) Penicillin
C) Glucose
D) Antihistamines

Answer 1

Penicillin

Question 2

Drugs are best absorbed from the gastrointestinal tract if they are:

A) hydrophilic.
B) amphipathic.
C) lipophobic.
D) lipophilic.

Answer 2

lipophilic.

Question 3

By which route are drugs not subject to the physiological process of absorption through a blood vessel wall?

A) Intramuscularly
B) Intradermally
C) Intravenously
D) Subcutaneously

Answer 3

Intravenously

Question 4

If a drug accumulates in one tissue (that is,the drug is extensively bound to a tissue),its volume of distribution is low.

Question 5

Drugs that are liver enzyme inducers may:

A) increase a drug's half-life.
B) increase a drug's metabolism.
C) inhibit a drug's therapeutic effect.
D) increase tissue distribution of another drug.