Deck 12: Benign Nonodontogenic Tumors

Question 1

Ubiquitous dendritic cells, found within mucosa and epidermis and having the function of processing foreign antigens and presenting relevant determinants to immunocompetent cells are known as:

A) Macrophages
B) Langerhans cells
C) Langhans giant cells
D) Histiocytes
E) Plasma cells

Answer 1

Langerhans cells

Question 2

A 16-year-old patient is found to have several well-defined radiopacities in his jaws. The patient is asymptomatic and teeth are vital. These lesions could be which of the following?

A) Central giant cell granulomas
B) Osteomas
C) Odontogenic keratocysts
D) Cherubism
E) None of the above

Answer 2

Osteomas

Question 3

A 17-year-old patient had asymptomatic sharply defined "punched out" radiolucencies of the body of the mandible subjacent to vital molar teeth. She also had related lucencies in the cranium. Microscopically, the lesions consisted predominantly of round cells with scattered eosinophils. This is descriptive of:

A) Cherubism
B) Multiple myeloma
C) Langerhans cell disease
D) Hyperthyroidism
E) Osteosarcoma

Answer 3

Langerhans cell disease

Question 4

A 33-year-old patient presents with a 1 * 2 cm swelling of the right side of his neck. All of the following might be considered in a clinical differential diagnosis except:

A) Lymphadenitis
B) Salivary gland tumor in the tail of the parotid
C) Giant cell granuloma
D) Lymphoepithelial cyst
E) Lymphoma

Question 5

All the following are components of McCune-Albright syndrome except:

A) Café-au-lait macules
B) Intestinal polyps
C) Fibrous dysplasia
D) Precocious puberty

Question 6

A 22-year-old woman has "spontaneous" loss of teeth nos. 28, 29, and 30. She has no periodontal pockets associated with the remainder of her teeth. Panoramic radiograph shows a sharply defined radiolucency in the area of tooth loss as well as another lucency in the body of her left mandible. She may have which of the following?

A) Cherubism
B) Cleidocranial dysplasia
C) Paget's disease
D) Hyperthyroidism
E) Langerhans cell disease

Question 7

The combination of multiple asymptomatic radiopaque jaw lesions with supernumerary teeth and intestinal polyps is indicative of:

A) Nevoid basal cell carcinoma syndrome
B) Gardner's syndrome
C) Diffuse sclerosing osteomyelitis
D) McCune-Albright syndrome
E) Langerhans cell disease

Question 8

A 15-year-old patient was found to have a 2 *3 cm multiloculated radiolucent lesion of his mandible. At the time of surgery, a solid, bloody lesion was removed. Histologically, it was composed of benign-appearing fibroblasts and multinucleated giant cells. This is most likely which of the following?

A) Hemangioma
B) Osteosarcoma
C) Peripheral giant cell granuloma
D) Central giant cell granuloma
E) Osteoporotic bone marrow defect

Question 9

Patients with central giant cell granulomas typically have which of the following abnormal laboratory findings?

A) Elevated immunoglobulins
B) Elevated serum alkaline phosphatase
C) Elevated serum acid phosphatase
D) Elevated serum calcium
E) None of the above

Question 10

A 20-year-old patient presents with increased mobility of only anterior mandibular teeth. Extensive loss of alveolar bone is noted radiographically without evidence of significant periodontal disease. The lesion is lucent with sharp margins. This would suggest which of the following?

A) Cherubism
B) Gardner's syndrome
C) Langerhans cell disease
D) Fibrous dysplasia
E) Paget's disease

Question 11

A biopsy of a periapical lesion associated with a vital tooth showed CD1a-positive round pale cells and many eosinophils. The diagnosis is:

A) Periapical abscess
B) Periapical granuloma
C) Solitary myeloma
D) Ewing's sarcoma
E) Langerhans cell disease

Question 12

Which of the following conditions significantly increases a patient's risk for development of adenocarcinoma of the colon?

A) Albright's syndrome
B) Neurofibromatosis
C) Cleidocranial dysplasia
D) Gardner's syndrome
E) None of the above

Question 13

A 21-year-old woman went to her dentist because of facial asymmetry. This had occurred gradually over 3 years. The patient has had no symptoms. A diffusely opaque lesion was found in her right maxilla. All lab tests (CBC, alkaline phosphatase, calcium) were within normal limits. Biopsy was interpreted as a fibro-osseous lesion. She most likely has:

A) Cementoblastoma
B) Fibrous dysplasia
C) Cherubism
D) Osteosarcoma
E) Chronic osteomyelitis

Question 14

Ossifying fibroma:

A) May range radiographically from a lucent to a mixed lucent and opaque lesion
B) Is typically seen in young adults
C) Is composed of fibrous tissue with foci of new bone
D) Is associated with vital teeth
E) All the above

Question 15

Which of the following could be classified as a benign fibro-osseous lesion?

A) Fibrous dysplasia
B) Idiopathic histiocytosis
C) Ewing's tumor
D) Odontogenic myxoma
E) Hematopoietic bone marrow defect

Question 16

Serum calcium would be significantly elevated in which of the following?

A) Central giant cell granuloma
B) Cherubism
C) Ameloblastoma
D) Langerhans cell disease (idiopathic histiocytosis) of the mandible
E) None of the above

Question 17

Which of the following lesions would most likely present radiographically as "floating teeth" in the jaw?

A) Odontoma
B) Osteoma
C) Ameloblastoma
D) Langerhans cell disease
E) Albers-Schonberg disease

Question 18

The ossifying fibroma is characterized clinically by:

A) Slow growth
B) Well-defined borders
C) Benign fibro-osseous microscopic appearance
D) Appearance in young adults
E) All the above