Deck 3: Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Question 1

A major factor in the killing of bacteria within a vacuole is

A)hydrogen peroxide.
B)elastase.
C)myeloperoxidase.
D)defensin.

Answer 1

hydrogen peroxide.

Question 2

Macrophages

A)process antigens.
B)physically present biologically modified antigens to lymphocytes.
C)secrete a lymphocyte-activating factor (IL-1) as a result of proper MHC recognition.
D)All of the above.

Answer 2

All of the above.

Question 3

Patients with leukocyte adhesion deficiency (LAD) can manifest

A)recurrent bacterial infection.
B)recurrent fungal infection.
C)often fatal bacterial and fungal infections.
D)All of the above.

Answer 3

All of the above.

Question 4

Match the type of leukocyte with the appropriate function. (Use each answer only once.)
Eosinophil

A)Principal leukocyte associated with phagocytosis
B)High concentrations of heparin and histamine
C)Homeostatic regulator of inflammation

Question 5

When an antibody-coated antigen is phagocytized, which component of the antibody molecule must fit into a receptor on the phagocytic cell?

A)VH region
B)VL region
C)Fab region
D)Fc region

Question 6

Hematopoiesis occurs in the yolk sac during the

A)embryonic period of gestation.
B)first trimester of gestation.
C)second trimester of gestation.
D)periods of severe anemia in children.

Question 7

Match the type of blood cell with the appropriate function. (An answer may be used more than once.)
Mononuclear monocytes-macrophages

A)Primary phagocytic cells
B)Recognition of foreign antigen
C)Antibody-synthesizing cells

Question 8

The sequence of blood cell development in the embryo and fetus is

A)yolk sac, liver-spleen, bone marrow.
B)yolk sac, bone marrow, liver/spleen.
C)liver-spleen, yolk sac, bone marrow.
D)bone marrow, liver-spleen, yolk sac.

Question 9

Match the type of leukocyte with the appropriate function. (Use each answer only once.)
Neutrophil

A)Principal leukocyte associated with phagocytosis
B)High concentrations of heparin and histamine
C)Homeostatic regulator of inflammation

Question 10

A basophil degranulates in a(n)

A)inflammatory reaction.
B)acute hypersensitivity reaction.
C)chronic tissue rejection.
D)Both A and B.

Question 11

The name of the structure formed within a phagocytic cell by the fusion of an engulfed (phagocytized) particle and enzymatic granules is a

A)vacuole.
B)cyst.
C)phagosome.
D)phagolysosome.

Question 12

If the first line of nonspecific body defense, intact skin, is cut with a piece of glass contaminated with Staphylococcus aureus, which cellular component of the immune system quickly responds?

A)T lymphocytes
B)B lymphocytes
C)Neutrophils
D)Platelets

Question 13

Eosinophils are increased in the circulating blood when a patient has _____________________ infection.

A)a fungal
B)an amebic parasitic
C)some types of parasitic
D)a bacterial

Question 14

Enhancement of phagocytosis by the coating of foreign particles with serum proteins is called

A)chemotaxis.
B)opsonization.
C)liposome formation.
D)agglutination.

Question 15

Match the type of blood cell with the appropriate function. (An answer may be used more than once.)
Plasma cells

A)Primary phagocytic cells
B)Recognition of foreign antigen
C)Antibody-synthesizing cells

Question 16

The name of the process that promotes attraction of phagocytic cells toward a foreign particle is

A)diapedesis.
B)chemotaxis.
C)phagolysosome formation.
D)cytolysis.

Question 17

Mononuclear cells are effective phagocytic cells against

A)staphylococci.
B)streptococci.
C)Mycobacterium tuberculosis.
D)pneumonia.

Question 18

The primary function of mature neutrophils is

A)to reduce inflammation.
B)to lyse parasites in the circulatory system.
C)antigen recognition.
D)phagocytosis.

Question 19

Match the type of blood cell with the appropriate function. (An answer may be used more than once.)
Lymphocytes

A)Primary phagocytic cells
B)Recognition of foreign antigen
C)Antibody-synthesizing cells

Question 20

Match the type of blood cell with the appropriate function. (An answer may be used more than once.)
Polymorphonuclear neutrophilic (PMN) leukocytes

A)Primary phagocytic cells
B)Recognition of foreign antigen
C)Antibody-synthesizing cells

Question 21

Match the disorder or deficiency with the appropriate description.
Myeloperoxidase deficiency

A)Disorder of oxidative metabolism
B)Impaired chemotaxis and delayed killing of ingested bacteria
C)Presents as a leukocyte adhesion deficiency
D)Mild to moderate defect in bacterial killing
E)Recurrent, severe bacterial infections

Question 22

Match the following two terms and definitions.
Inflammation

A)Characterized by local redness, swelling, and pain
B)An infection-induced systemic condition

Question 23

Match the disorder or deficiency with the appropriate description.
Chronic granulomatous disease (CGD)

A)Disorder of oxidative metabolism
B)Impaired chemotaxis and delayed killing of ingested bacteria
C)Presents as a leukocyte adhesion deficiency
D)Mild to moderate defect in bacterial killing
E)Recurrent, severe bacterial infections

Question 24

Match the following two terms and definitions.
Sepsis

A)Characterized by local redness, swelling, and pain
B)An infection-induced systemic condition

Question 25

Match the type of leukocyte with the appropriate function. (Use each answer only once.)
Basophil

A)Principal leukocyte associated with phagocytosis
B)High concentrations of heparin and histamine
C)Homeostatic regulator of inflammation

Question 26

Match the monocyte-macrophage disorder with the appropriate description.

-Niemann-Pick disease

A)Deficiency of sphingomyelinase
B)Deficiency of $\alpha$ -glucocerebrosidase

Question 27

Match the disorder or deficiency with the appropriate description.
Specific granule deficiency

A)Disorder of oxidative metabolism
B)Impaired chemotaxis and delayed killing of ingested bacteria
C)Presents as a leukocyte adhesion deficiency
D)Mild to moderate defect in bacterial killing
E)Recurrent, severe bacterial infections

Question 28

Match the disorder or deficiency with the appropriate description.
Chédiak-Higashi anomaly

A)Disorder of oxidative metabolism
B)Impaired chemotaxis and delayed killing of ingested bacteria
C)Presents as a leukocyte adhesion deficiency
D)Mild to moderate defect in bacterial killing
E)Recurrent, severe bacterial infections

Question 29

Match the monocyte-macrophage disorder with the appropriate description.

-Gaucher's disease

A)Deficiency of sphingomyelinase
B)Deficiency of $\alpha$ -glucocerebrosidase

Question 30

Match the disorder or deficiency with the appropriate description.
Complement receptor 3 (CR3) deficiency

A)Disorder of oxidative metabolism
B)Impaired chemotaxis and delayed killing of ingested bacteria
C)Presents as a leukocyte adhesion deficiency
D)Mild to moderate defect in bacterial killing
E)Recurrent, severe bacterial infections