Deck 25: Hypersensitivity Reactions

Question 1

All of the following are examples of Type II hypersensitivity reactions except

A)Farmer's lung and the Arthus reaction.
B)immediate transfusion reactions and Hemolytic disease of the newborn (HDN).
C)antibody-dependent, cell-mediated cytotoxicity involving NK cells or macrophages expressing Fc receptors.
D)antireceptor antibodies such as those expressed in autoimmune thyroid disease.

Answer 1

Farmer's lung and the Arthus reaction.

Question 2

Match the terms with the appropriate description.
Anaphylactoid reaction

A)Cell-mediated
B)Antibody-mediated
C)Dependent on the host's response to a subsequent exposure of antigen
D)Not mediated by antigen-antibody interaction

Answer 2

Not mediated by antigen-antibody interaction

Question 3

The components involved in a positive skin test for tuberculosis (TB) are

A)T lymphocytes and macrophages.
B)segmented neutrophils and monocytes.
C)B lymphocytes and macrophages.
D)IgE antibodies.

Answer 3

T lymphocytes and macrophages.

Question 4

Match the terms with the appropriate description.
Delayed hypersensitivity

A)Cell-mediated
B)Antibody-mediated
C)Dependent on the host's response to a subsequent exposure of antigen
D)Not mediated by antigen-antibody interaction

Question 5

Type I hypersensitivity reactions are characterized by

A)activation of complement.
B)antigen cross-links with IgE on mast cells.
C)being potentially fatal.
D)Both B and C.

Question 6

Cell-mediated immunity is responsible for

A)contact sensitivity.
B)elimination of tumor cells bearing neoantigens.
C)rejection of foreign graft tissue.
D)all of the above.

Question 7

Hemolytic disease of the newborn is an example of a ____________ hypersensitivity reaction.

A)type I
B)type II
C)type III
D)type IV

Question 8

The Arthus reaction is associated with the immune phenomenon of

A)deposition of immune complexes in blood vessels.
B)release of histamine from tissue basophils.
C)destruction of body tissue by cytotoxic T lymphocytes.
D)phagocytosis of IgG-coated erythrocytes.

Question 9

Anaphylaxis is characterized by all the following statements except

A)it can cause death caused by asphyxiation.
B)there is massive release of histamine from mast cells and basophils.
C)there was prior sensitization to an allergen.
D)it is associated with a significant increase in eosinophils in the circulating blood.

Question 10

Immune complex reactions can

A)suppress or augment the immune response.
B)inhibit tumor cell destruction.
C)be deposited in blood vessel walls, glomerular membranes, and other sites.
D)All of the above.

Question 11

Asthma is an example of a _____________ hypersensitivity reaction.

A)type I
B)type II
C)type III
D)type IV

Question 12

Match the terms with the appropriate description.
Immunization or sensitization

A)Cell-mediated
B)Antibody-mediated
C)Dependent on the host's response to a subsequent exposure of antigen
D)Not mediated by antigen-antibody interaction

Question 13

Match the terms with the appropriate description.
Immediate hypersensitivity

A)Cell-mediated
B)Antibody-mediated
C)Dependent on the host's response to a subsequent exposure of antigen
D)Not mediated by antigen-antibody interaction

Question 14

Histamine can

A)lead to constriction of bronchial smooth muscle.
B)exert an anticoagulant effect.
C)cause decreased capillary permeability.
D)enhance opsonization in phagocytosis.