Deck 21: Infectious Mononucleosis

Question 1

In the adult population, ________ of individuals with acute infectious mononucleosis do not produce heterophile antibodies.

A)5% to 10%
B)10% to 20%
C)20% to 50%
D)50% to 100%

Answer 1

10% to 20%

Question 2

Approximately which percentage of young adults demonstrates antibodies to EBV?

A)Less than 10%
B)25%
C)50%
D)100%

Answer 2

Less than 10%

Question 3

Which of the following stages of infectious mononucleosis infection is characterized by antibody to Epstein-Barr nuclear antigen (EBNA)?

A)Recent (acute) infection
B)Past infection (convalescent) period
C)Reactivation of latent infection
D)Both B and C.

Answer 3

Both B and C.

Question 4

Epstein-Barr virus (EBV) is

A)a DNA herpesvirus.
B)harbored by B lymphocytes in latent infections.
C)the most ubiquitous virus known to humans.
D)All of the above.

Question 5

A more recent methodology used to detect antibodies to EBNA is

A)monospot.
B)monoslide.
C)ELISA.
D)immunofluorescence.

Question 6

IgM type of heterophile antibodies usually appear during the __________ phase of infectious mononucleosis.

A)acute
B)chronic
C)latent
D)carrier

Question 7

All the following statements about Epstein-Barr virus (EBV) are true except that it

A)usually causes an acute, benign condition.
B)usually causes a self-limiting, lymphoproliferative condition.
C)is the cause of Burkitt's lymphoma.
D)is not an agent in the development of nasopharyngeal carcinoma.

Question 8

The use of horse erythrocytes in rapid slide tests for infectious mononucleosis increases the

A)readability.
B)sensitivity.
C)specificity.
D)All of the above.

Question 9

Match each procedure to the appropriate description.
Davidsohn differential test

A)Distinguishes between heterophile antibodies; uses beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes.
B)Detects heterophile antibodies and uses horse erythrocytes.
C)Detects heterophile antibodies and uses sheep erythrocytes.

Question 10

In rapid MonoSlide testing, a false-positive result can be caused by

A)observing agglutination after the observation time.
B)misinterpreting agglutination.
C)residual heterophile antibody present after clinical symptoms have subsided.
D)All of the above.

Question 11

Immunocompetent individuals maintain EBV as a(n)

A)active infection.
B)chronic latent infection.
C)asymptomatic carrier.
D)symptomatic carrier.

Question 12

Match each procedure to the appropriate description.
MonoSlide agglutination test

A)Distinguishes between heterophile antibodies; uses beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes.
B)Detects heterophile antibodies and uses horse erythrocytes.
C)Detects heterophile antibodies and uses sheep erythrocytes.

Question 13

A blood transfusion from an immune donor to a nonimmune recipient may produce

A)no effect.
B)a primary infection.
C)a secondary infection.
D)a reactivated infection.

Question 14

The MonoSlide test is based on the agglutination of

A)sheep erythrocytes.
B)horse erythrocytes.
C)latex-coated particles.
D)guinea pig antigen.

Question 15

EBV is transmitted primarily by

A)close contact with infectious oropharyngeal secretions.
B)blood transfusion.
C)transplacental exposure.
D)transplanted organs or tissues.

Question 16

Viral capsid antigen (VCA) is produced by

A)phagocytic neutrophils.
B)infected T lymphocytes.
C)infected B lymphocytes.
D)Both B and C.

Question 17

Match each procedure to the appropriate description.
Paul-Bunnell screening test

A)Distinguishes between heterophile antibodies; uses beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes.
B)Detects heterophile antibodies and uses horse erythrocytes.
C)Detects heterophile antibodies and uses sheep erythrocytes.

Question 18

EBV is typically manifested by

A)young children.
B)young adults.
C)middle-aged individuals.
D)older adults.

Question 19

In infectious mononucleosis, EBV

A)infects B lymphocytes.
B)produces lymphocytes in peripheral blood with T cell characteristics.
C)induces a cytotoxic response against the EBV-infected circulating B lymphocytes.
D)All of the above.

Question 20

Anti-VCA immunoglobulin G (IgG) is usually detectable within

A)24 hours.
B)72 hours.
C)3 to 5 days.
D)4 to 7 days.

Question 21

Immunoglobulin M (IgM) heterophile antibody is characterized by absorption by guinea pig kidney cells.

Question 22

Immunoglobulin M (IgM) heterophile antibody is characterized by no absorption by beef erythrocytes.

Question 23

Immunoglobulin M (IgM) heterophile antibody is characterized by reaction with horse, ox, and sheep erythrocytes.