Deck 22: Bone Marrow Failure

Question 1

What is the treatment of choice for long-term survival for patients younger than 40 years old with aplastic anemia?

A)blood transfusion
B)growth factors
C)antibiotic agents
D)hematopoietic stem cell transplant

Answer 1

hematopoietic stem cell transplant

Question 2

Bone marrow failure causes pancytopenia

A)in the peripheral blood only.
B)in the bone marrow only.
C)in both the bone marrow and the peripheral blood.
D)in the bone marrow, peripheral blood, and spleen.

Answer 2

in both the bone marrow and the peripheral blood.

Question 3

Which of the following is most useful for considering the diagnosis of bone marrow failure?

A)a hemoglobin concentration of 11 g/dL
B)an absolute neutrophil count of less than 0.5 * 103/dL
C)a hypercellular bone marrow
D)abnormal platelet function tests

Answer 3

an absolute neutrophil count of less than 0.5 * 103/dL

Question 4

Which of the following patients fits the typical patient demographics for aplastic anemia?

A)infant
B)a 65-year-old adult
C)a 45-year-old adult
D)a 7-year-old child

Question 5

Which of the following is an inherited disorder with pancytopenia,malformed kidneys,and mental deficiency?

A)myelodysplasia
B)Fanconi anemia
C)Diamond-Blackfan anemia
D)secondary aplastic anemia

Question 6

Which of the following would be an unusual bone marrow finding in aplastic anemia?

A)predominance of lymphocytes, plasma cells, and mast cells
B)hypocellular
C)increased megakaryocytes
D)increased fat

Question 7

What distinguishes PRCAs such as Diamond-Blackfan syndrome from aplastic anemia?

A)peripheral red blood count
B)number of erythroid stem cells in the bone marrow
C)normal cellularity of myeloid cells
D)red cell indices

Question 8

Paroxysmal nocturnal hemoglobinuria has a high degree of association with which one of the following disorders?

A)aplastic anemia
B)Fanconi anemia
C)Diamond-Blackfan anemia
D)CDA

Question 9

Pancytopenia is a term that means

A)decrease in red cells, white cells, and platelets.
B)increase in red and white cells.
C)decrease in any two blood cell lines.
D)increase in white cells and platelets.

Question 10

Normal bone marrow cells being replaced with malignant cells is called

A)Diamond-Blackfan anemia.
B)CDA II.
C)PRCA.
D)myelophthisic anemia.

Question 11

The anemia associated with severe kidney disease is caused primarily by

A)damage to stem cells by urea.
B)replacement of bone marrow cells with fat.
C)deficiency of erythropoietin.
D)bleeding into the urine.

Question 12

What is the treatment of choice for a patient older than 40 years old with aplastic anemia?

A)hematopoietic stem cell transplant
B)antibiotic agents
C)antithymocyte globulin (ATG)
D)erythropoietin

Question 13

Diepoxybutane causes chromosomal breakage in which of the following disorders?

A)acquired aplastic anemia
B)Fanconi anemia
C)Diamond-Blackfan anemia
D)CDA

Question 14

What surface antigen on cells identifies them as a hematopoietic stem cell?

A)CD8
B)CD34
C)CD55
D)CD59

Question 15

The red cell morphology associated with aplastic anemia is

A)normocytic normochromic with no polychromasia.
B)normocytic normochromic with marked polychromasia.
C)microcytic hypochromic with marked polychromasia.
D)microcytic normochromic with no polychromasia.

Question 16

The cause of acquired idiopathic aplastic anemia is

A)Epstein-Barr virus.
B)chemicals such as benzene.
C)radiation.
D)unknown.

Question 17

Which of the following is a feature of type II congenital dyserythropoietic anemia (CDA II)?

A)giant, multinucleated red cell precursors
B)microcytic red cells
C)positive sucrose hemolysis test
D)negative acidified serum test (Ham test)