Deck 16: Gastrointestinal System Toxicity and Oral Exposure Gi Tract, Pancreas, Liver

Question 1

Which substances are known to stain teeth, but not necessarily lead to other toxicity?

Answer 1

Coffee, tea, tetracycline, chlorhexidine and fluoride may stain teeth without any other toxic implications.

Question 2

What toxic metal results in gingivitis but is not due to plaque formation or bacterial action on teeth?

Answer 2

Mercury's triad of effects include gingivitis, tremor and change in behavior.

Question 3

What substance normally secreted into the intestinal tract cause ROS and RNS formation in the esophagus if GERD occurs?

Answer 3

Bile acids which are secreted for the absorption of lipid also cause the formation of these reactive products that may lead to cancers of the G.I. tract.

Question 4

Why does nickel target the jejunum?

Question 5

What does chronic cocaine cause?

Question 6

Can cancers of the exocrine pancreas be caused by ingestion of PAHs?

Question 7

Why is allyl alcohol a model zone 1 toxicant of the liver while carbon tetrachloride would be a model zone 3 toxicant?