Deck 11: Development of the Nervous System

Question 1

Which of the following functions as a local organizer to induce the development of the tectum and cerebellum in rostral and caudal postions, respectively?

A) Zona limitans intrathalamica
B) Midbrain-hindbrain boundary
C) Anterior neural ridge
D) Telencephalon

Answer 1

B

Question 2

Which term refers to the segments of hindbrain tissue separated by lineage-restriction boundaries?

A) Rhondomeres
B) Rhabdomeres
C) Rhombomeres
D) Telomeres

Answer 2

C

Question 3

On the basis of our knowledge of dorso-ventral patterning of the neural tube, how would you treat cultured embryonic stem cells in order to obtain motor neurons for regenerative medicine?

A) Sonic hedgehog + retinoic acid
B) Sonic hedgehog + Bone morphogenetic protein
C) Bone morphogenetic protein
D) Bone morphogenetic protein + retinoic acid

Answer 3

A

Question 4

Which of the following is not true of neuroblast formation in the Drosophila embryo?

A) Embryos that lack both Notch and Delta function do not develop neuroblasts
B) Initially, all cells of the proneural cluster have the potential of becoming neuroblasts
C) Cells in which the Notch receptor is activated become epidermal cells
D) Cells that are Delta-expressing cells become neuroblasts

Question 5

From which layer do all neurons and glia of the brain and spinal cord in a vertebrate embryo arise?

A) Mantle zone
B) Intermediate zone
C) Ventricular zone
D) Marginal zone

Question 6

As new neurons migrate outward to build up concentric layers of neural tissue in the brain and spinal cord, which layer consists of cell bodies and is referred to as gray matter?

A) Ventricular zone
B) Mantle zone
C) Intermediate zone
D) Marginal zone

Question 7

As new neurons migrate outward to build up concentric layers of neural tissue in the brain and spinal cord, which layer consists of neuronal axons and is referred to as white matter?

A) Ventricular zone
B) Mantle zone
C) Intermediate zone
D) Marginal zone

Question 8

Which of the following is not true of targeting motor neurons to specific regions of the developing limb?

A) The transcription factor, Lim1, provides motor neurons with positional identity within the spinal cord
B) Motor neurons are guided by chemorepellents
C) Motor neurons express specific receptors that guide their migration into the limb
D) Inverting the neural tube results in failure of motor neurons to innervate their correct muscles

Question 9

Which of the following is true of commissural axon guidance in the neural tube?

A) Changes in the Robo3 receptor are important for selectively preventing commissural neuron midline crossing
B) Netrin-1 binds to its receptor, DCC, and is a chemorepellant.
C) Robo1/2 is a receptor that attracts commissural neurons
D) Commissural neurons are allowed to cross the midline multiple times

Question 10

Which of the following is not associated with neuromuscular junctions?

A) Acetylcholine receptors
B) Synaptic cleft
C) Synaptic vesicle
D) Dopamine