Deck 6: Effects of Exercise on Mucosal Immunity

Question 1

Which of the following is the most common secretory immunoglobulin

A) IgM
B) IgG
C) IgE
D) Iγδ
E) IgA

Answer 1

E

Question 2

Which of the following statements about the fragment crystallisable (Fc) portion of the Ig molecule is TRUE?

A) The Fc portion where the Ig binds to antigen
B) There are two Fc portions
C) The Fc portion is where the Ig binds to receptors present on effector molecules and cells
D) The Fc portion helps the Ig act as an opsonin
E) The Fc portion binds the Ig to a secretory component

Answer 2

C

Question 3

Selective deficiency of IgA is associated with a...

A) Reduced vaccine response
B) Improved vaccine response
C) Lower incidence of infections
D) Higher incidence of infections
E) Impaired DTH response

Answer 3

D

Question 4

What is the main function of secretory component?

A) To join two IgA monomers as dimeric IgA
B) To allow IgA translocation across the mucosal epithelium
C) To protect secretory IgA against degradation by proteases
D) To allow antigen binding to the Fab portions of secretory IgA
E) To increase the rate at which IgA is secreted by plasma cells

Question 5

Which of the following methods of reporting salivary SIgA is thought to best reflect the amount of IgA available to the mucosal surfaces?

A) SIgA concentration
B) SIgA relative to saliva osmolality
C) SIgA relative to total saliva protein concentration
D) SIgA secretion rate
E) SIgA relative to plasma albumin concentration

Question 6

Which of the following statements is FALSE regarding the study of Gleeson et al. (1999b) in a cohort of elite Australian swimmers?

A) SIgA concentration increased with each additional month of training
B) SIgA concentration fell with each additional month of training
C) Pre-season SIgA concentration was predictive of infection frequency
D) Mean pre-training SIgA concentration was predictive of infection frequency
E) None of the above

Question 7

Neville et al. (2008) found that a fall to less than 40% of an individual's usual healthy SIgA concentration was indicative of...

A) A 25% chance of contracting an infection within 3 weeks
B) A 50% chance of contracting an infection within 3 weeks
C) A 75% chance of contracting an infection within 3 weeks
D) A 100% chance of contracting an infection within 3 weeks
E) A decrease in infection risk over the next 3 weeks

Question 8

Salivary lactoferrin concentrations are reported to be...

A) Lower in elite athletes compared with sedentary controls
B) Related to saliva IgA concentration
C) Lower in response to a graded exercise to exhaustion
D) An indicator of subjective fatigue
E) All of the above

Question 9

The changes in salivary SIgA with strenuous acute exercise may reflect altered mobilisation of the pIgR as a consequence of increased sympathetic nervous system activation.

Question 10

Decreases in salivary flow rate during high intensity exercise are most likely to be caused by increases in plasma cortisol.