Deck 4: Effects of Exercise on Innate Immune Function

Question 1

Which of the following cell types involved in innate immunity shows the largest increase in circulating numbers (compared with pre-exercise) during recovery from prolonged strenuous exercise?

A) Neutrophils
B) Monocytes
C) Macrophages
D) Natural killer cells
E) Basophils

Answer 1

A

Question 2

The number of neutrophils engaging in phagocytosis is decreased by acute exercise but their phagocytic capacity is increased.

Answer 2

False

Question 3

Which of the following aspects of neutrophil function is not decreased during intensive exercise?

A) Chemotaxis
B) Phagocytosis
C) LPS-stimulated degranulation
D) Spontaneous degranulation
E) Respiratory burst

Answer 3

D

Question 4

Which of the following is not involved in regulation of innate immune cell function during exercise?

A) Leptin
B) Adrenaline
C) Cortisol
D) IL-6
E) Activated complement proteins

Question 5

Exercise training increases blood neutrophil counts in those with chronic inflammatory conditions (e.g. people who are obese)

Question 6

Which of the following is an acute-phase protein and increases after prolonged exercise?

A) Insulin
B) C-reactive protein
C) Immunoglobulin A
D) Interleukin 6
E) Haemoglobin

Question 7

A reduction in the expression of which of the following proteins on the surface of monocytes could explain the exercise-induced depression of both innate and acquired immune cell functions?

A) CD14
B) CD16
C) TLR4
D) TLR9
E) None of the above

Question 8

In response to acute exercise, there is a preferential mobilisation of CD14⁺/CD16⁺ expressing monocytes.

Question 9

Which of the following macrophage functions is depressed by prolonged exercise?

A) Chemotaxis
B) Phagocytosis
C) Reactive oxygen species production
D) Antigen presentation
E) Anti-tumour activity

Question 10

Exercise training has consistently been shown to depress natural killer cell numbers and cytolytic activity.