Deck 7: Novel Psychoactive Substances

Question 1

Substances that are purposely designed to mimic the pharmacological effect of a regulated or controlled substance are called

A) positional isomers
B) analogs
C) failed pharmaceuticals
D) prescription replicates
E) none of the above

Answer 1

B

Question 2

Based on the discussion in this chapter, are these two substances considered to be substantially structurally similar?

A) Yes
B) No
C) Need more data on 3D shape
D) No set answer; this is subjective
E) none of the above

Answer 2

D

Question 3

These two compounds both bind with opioid receptors in the body and induce similar physiological effects. They can be considered as

A) substantially pharmacologically similar
B) substantially chemically similar
C) both controlled substances in Schedule I
D) substantially physio-chemically similar
E) none of the above

Answer 3

A

Question 4

SCRA are

A) synthetic cocaine receptor analogs
B) synthetic cathinone receptor agents
C) synthetic cannabinoid receptor agonists
D) special classes of recreational agents
E) none of the above

Question 5

Abbreviated names for synthetic cannabinoids is generally based on

A) the street term
B) the year it was introduced
C) the acid/base category of the substance
D) IUPAC name
E) none of the above

Question 6

Given the following structure of a synthetic cannabinoid: Which area is the linked group?

A) 1
B) 2
C) 3
D) 4

Question 7

Given the following structure of a synthetic cannabinoid: Which area is the core?

A) 1
B) 2
C) 3
D) 4

Question 8

Given the following structure of a synthetic cannabinoid: Which area is the linker?

A) 1
B) 2
C) 3
D) 4

Question 9

Given the following structure of a synthetic cannabinoid: Which area is the tail?

A) 1
B) 2
C) 3
D) 4

Question 10

Simulants, such as the novel cathinones, are often also

A) depressants
B) hallucinogens
C) sedative/hypnotics
D) synthetic cannabinoids
E) none of the above

Question 11

Which group of NPSs is of greatest current concern for causing fatalities

A) cannabinoids
B) opioids
C) stimulants
D) synthetic benzodiazepines
E) none of the above

Question 12

What is the difference between opiates and opioids?

A) nothing; they mean the same thing
B) opioids are naturally occuring or semi-synthetic compounds from the opium plant
C) opiates are naturally occuring or semi-synthetic compounds from the opium plant
D) opioids are much less dangerous than opiates
E) none of the above

Question 13

Why are NPSs such a challenge to routine seized drug analysis

A) when first encountered, there are no reference standards available
B) they are undetectable using typical schemes
C) they are usually found at very low concentrations
D) all of the above
E) none of the above

Question 14

In the context of NPSs, what are positional isomers?

A) stereoisomers of existing substances
B) new substances that differ from a previously identified one only in where a substituent is located
C) compounds that fall in a different category or position on the controlled substances list
D) compounds with reversed positions of the molecular ion in an EI-MS spectrum
E) none of the above

Question 15

In this chapter, a target compound is one that

A) a validated method might detect but cannot identify
B) has a similar pKa and logP to controlled substances
C) a validated method was designed to detect
D) can only be detected using one analytical scheme
E) none of the above

Question 16

Suppose a validated GC-MS method is designed to detect stimulants. A peak that does not correlate with any of the compounds for which the method is validated appears in the chromatogram. This peak represents a

A) target compound
B) a non-target compound
C) a positional isomer of a non-target compound
D) a real headache for the analyst
E) none of the above

Question 17

A toxicology laboratory decides to generate a GC-MS method that will detect acidic or neutral compounds with logP values of 1 or less and that are not broken down in the injection port. This is a _______ method

A) target method
B) non-target method
C) a validated target method
D) screening method
E) none of the above

Question 18

The following are three novel fentalog compounds: Which general category of novel substances do they belong to?

A) SCRA
B) stimulants/hallucinogens
C) NSO
D) novel benzodiazepines
E) more than one of the above
F) none of the above

Question 19

The following are three novel fentalog compounds:

These compounds are examples of

A) THC analogs
B) enantiomers
C) stereoisomers
D) positional isomers
E) more than one of the above
F) none of the above

Question 20

The following are three novel fentalog compounds:
An analyst is trying to differentiate between these three compounds. They obtain a EI-MS. Which of these compounds will have distinctly different EI mass spectra?

A) A and B
B) B and C
C) A and C
D) all would be clearly different
E) none of the above

Question 21

The following are three novel fentalog compounds: Which of these techniques is best to differentiate all three of these compounds?

A) EI-MS
B) FTIR
C) HRMS
D) NMR
E) more than one of the above
F) none of the above

Question 22

The following are three novel fentalog compounds: An analyst uses HRMS to characterize these compounds. What information can be derived from exact mass data?

A) enough to differentiate these structures
B) enough to differentiate one structure from the other two
C) enough to determine which form is the most toxic
D) enough to determine which form is the least toxic
E) more than one of the above
F) none of the above