Deck 2: Transdermal Drug Delivery Systems TDDS and Formulations

Question 1

Which of the following drugs can not be given as transdermal administration?

A)Drugs with very short half life
B)Drugs with narrow therapeutic index
C)Easy removal and termination
D)Drug against peptic ulcer

Answer 1

Drug against peptic ulcer

Question 2

What are the characteristics of the monolithic devices?

A)The drug has a large therapeutic index
B)Aqueous solution
C)Control drug release by partitioning the drug from oil
D)Administration of emulsion

Answer 2

The drug has a large therapeutic index

Question 3

Which of the following characteristics is suitable for transdermal drug?

A)Large drug dose
B)Large molecular size
C)Drugs with narrow therapeutic index
D)Drug which are metabolized in the skin

Answer 3

Drugs with narrow therapeutic index

Question 4

The rate at which monolithic devices transfer drug the patient body is proportional to________ of time.

A)Square of time
B)The square root of time
C)Twice the time
D)Half the time

Question 5

What are the characteristics of the reservoir or membrane devices?

A)The drug has a large therapeutic index
B)Drug permeation rate is high
C)Control drug release by partitioning the drug from oil
D)Administration of emulsion

Question 6

What are the characteristics of the mixed monolithic reservoir devices?

A)The drug has a large therapeutic index
B)Drug permeation rate is high
C)The drug polymer matrix is layered by rate controlling membrane
D)Administration of emulsion

Question 7

Which of the following is false in regarding reservoir devices?

A)These devices are used when the drug permeation rate is rapid
B)The release of the drug is controlled
C)Suitable for low therapeutic index
D)The drug is contained in a powder from floating on liquid

Question 8

Which of the following is true for monolithic devices?

A)These devices are used when the drug permeation rate is rapid
B)The release of the drug is controlled
C)Suitable for drugs with large therapeutic index
D)The drug is contained in a powder form floating on liquid

Question 9

The absorption of the ophthalmic drug does not depend on which of the following?

A)Physicochemical properties of permeating molecule
B)Drainage of tears
C)Output of tears
D)Size of the eyeball

Question 10

Which of the following is false for monolithic devices?

A)The drug used for these devices has large therapeutic index
B)There are three categories of matrix devices
C)1st type has the drug dissolved in the polymer matrix
D)2nd type has drug delivery

Question 11

Problems with opioid TDDS include.

A)Poor patient compliance
B)Allergy
C)Constipation.
D)Respiratory depression.

Question 12

Regarding the skin:

A)The epidermis is the thickest layer.
B)The stratum corneum is the greatest barrier to transdermal transport.
C)The dermis has a rich capillary blood supply.
D)Skin hydration is a cause of inter-individual variation in drug absorption.

Question 13

How much thickness of the dermis layer?

A)2 to 7 nm
B)3 to 5 nm
C)3 to 6 nm
D)5 to 8 nm

Question 14

TDDS is usually only suitable for drugs of what level of potency?

A)Typically only for drugs of high potency.
B)Low potency
C)High to low potency
D)Low to high potency

Question 15

In the use of TDDS for drug application ? size has to be considered reasonable?

A)Strip size
B)Patch size
C)Film size
D)Diskette size

Question 16

What is the largest organ of the body?

A)Liver
B)Lungs
C)Skin
D)Brain

Question 17

Which of the following is false for Merits of the TDDS.

A)Avoidance of the First pass effect
B)A stable and controlled blood level
C)Termination at any time is conceivable
D)Skin irritation and allergic response

Question 18

How many layer are seen in monolithic TDDS design?

A)4
B)3
C)5
D)2

Question 19

How many layer are seen in membrane-controlled system?

A)3
B)5
C)4
D)6

Question 20

A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field.

A)Iontophoresis
B)Sonophoresis
C)Electrophoresis
D)Ion exchange

Question 21

A physical method of permeation enhancement that involves the use of high frequency ultrasound. It is thought to influence the integrity of the SC and thus affect its penetrability.

A)Iontophoresis
B)Sonophoresis
C)Electrophoresis
D)Ion exchange

Question 22

Which component are not included in combination of the SEDDS formulation?

A)Oil
B)Lipid
C)Drug
D)Wax

Question 23

SEDDSs emulsify spontaneously to produce fine oil in water emulsions when introduced into an aqueous phase under gentle agitation and spread readily in the____________.

A)GIT
B)RT
C)UT
D)Liver

Question 24

SEDDSs produce emulsion with droplet size between ____________.

A)200 to 400nm
B)100 to 300nm
C)10 to 100nm
D)1000nm

Question 25

Self micro emulsifying drug delivery systems (SMEDDSs) form transparent micro emulsions with droplet size of less than__________.

A)50 nm
B)70 nm
C)100 nm
D)200 nm