Deck 4: Neoplasia

Question 1

Which of the following conditions is characterized by a defect of a DNA repair enzyme?

A) Neurofibromatosis
B) Hereditary polyposis coli
C) Xeroderma pigmentosum
D) Wilms' tumor
E) Hodgkin's lymphoma

Answer 1

Xeroderma pigmentosum

Question 2

Teratomas originate from:

A) Germ cells of the ovary
B) Brain cells
C) Thyroid cells
D) Endocrine cells of the pancreas
E) Fallopian tubes

Answer 2

Germ cells of the ovary

Question 3

The cancer of chimney sweeps identified in the eighteenth century in England was related to a component of tar that is chemically classified as:

A) Polycyclic hydrocarbons
B) Aflatoxin B₁
C) Azo-dyes
D) Naphthylamine
E) Arsenic

Answer 3

Polycyclic hydrocarbons

Question 4

Hodgkin's lymphoma is a neoplasm that typically involves the:

A) Brain
B) Lungs
C) Heart
D) Liver
E) Lymph nodes

Question 5

The incidence of which cancer has been rising in the United States during the past 20 years?

A) Carcinoma of the lung
B) Carcinoma of the liver
C) Carcinoma of the stomach
D) Carcinoma of the thyroid
E) Malignant brain tumors

Question 6

Alpha-fetoprotein is a tumor marker for malignant tumors originating in the:

A) Brain
B) Lung
C) Liver
D) Uterus
E) Thyroid

Question 7

Which of the following physical carcinogens is the cause of most skin cancers in humans?

A) Ultraviolet light
B) Infrared light
C) X-rays
D) Radon
E) Gamma rays

Question 8

Carcinoma of the stomach has the highest incidence in:

A) England
B) Japan
C) United States
D) Israel
E) France

Question 9

The most important source of chemical carcinogens in the human habitat is:

A) Cigarette smoke
B) Asbestos
C) Air pollution
D) Food additives
E) Pesticides in the food

Question 10

Retinoblastoma gene (Rb-1)is classified as a(n):

A) Oncogene
B) Tumor suppressor gene
C) Point mutation
D) Gene amplification
E) Viral oncogene inserted into the human genome

Question 11

Many tumors secrete their own growth factors.This form of stimulation is called:

A) Autocrine
B) Heterocrine
C) Paracrine
D) Endocrine
E) Exocrine

Question 12

Workers employed in the chemical industry and exposed to high levels of aniline dyes are at increased risk of developing cancer of the:

A) Brain
B) Lung
C) Stomach
D) Urinary bladder
E) Testis

Question 13

A lung tumor that has spread to the brain has metastasized via:

A) Lymphatics
B) Nerves
C) Blood vessels
D) Cerebrospinal fluid
E) Pleural fluid

Question 14

Human papillomavirus (HPV)has been implicated in the pathogenesis of carcinoma of the:

A) Lips
B) Cervix of the uterus
C) Liver
D) Ovaries
E) Pancreas