Deck 5: Neoplasia

Question 1

Which mechanism affecting the genes or chromosomes accounts for the activation of the c-myc protooncogene in Burkitt lymphoma cells?

A) Overexpression
B) Amplification
C) Point mutation
D) Translocation
E) Inactivation of its promotor

Answer 1

Translocation

Question 2

Helicobacter pylori infection predisposes to formation of gastric tumors, but the association between the bacterial infection and a gastric tumor is the strongest for

A) adenocarcinoma of the stomach
B) gastrointestinal stromal tumors
C) marginal zone lymphomas
D) T-cell lymphoma
E) Burkitt lymphoma

Answer 2

marginal zone lymphomas

Question 3

Clubbing of the digits, periosteal new bone formation on the metatarsals, metacarpals, and proximal phalanges, and arthritis of adjacent joints is a paraneoplastic syndrome most often associated with carcinoma of the

A) thyroid
B) larynx
C) bronchi
D) liver
E) stomach

Answer 3

bronchi

Question 4

Microsatellite instability, a marker of DNA mismatch repair, is typically found in

A) hereditary nonpolyposis colon cancer
B) familial adenomatous polyposis coli
C) T-cell lymphoma
D) B-cell lymphoma
E) myelogenous leukemia

Question 5

Germ line mutation of the Von Hippel-Lindau (VHL) gene is associated with formation of retinal angiomas and

A) glioblastoma multiforme
B) oligodendroglioma
C) neurinomas
D) ependymomas
E) cerebellar hemangioblastomas

Question 6

Which one of the following carcinomas is locally invasive but rarely forms metastases in lymph nodes and distant sites?

A) Basal cell carcinoma of the skin
B) Squamous cell carcinoma of the skin
C) Oat cell carcinoma of the lung
D) Transitional cell carcinoma of the urinary bladder
E) Adenocarcinoma of the stomach

Question 7

Which enzymes in the liver account for the activation of most procarcinogens into carcinogens?

A) Cytochrome P-450-dependent mono-oxidases
B) Aminotransferases
C) Hydroxylases
D) Glutathione dehydrogenase
E) Caspases

Question 8

Matrix metalloproteinases secreted by tumor cells are important for which feature of malignant tumors?

A) Desmoplasia
B) Anaplasia
C) Invasiveness
D) Apoptosis
E) Differentiation

Question 9

Germ line mutation of E-cadherin is found in familial cases of

A) lymphoblastic lymphoma
B) Ewing sarcoma
C) neuroblastoma
D) gastric carcinoma
E) seminoma

Question 10

Which of the following tumors occurs most often in the ovary?

A) Chondroma
B) Hemangioma
C) Leiomyoma
D) Transitional cell papilloma
E) Cystadenoma

Question 11

Which is the most common radiation-induced cancer in humans?

A) Thyroid cancer
B) Chronic lymphocytic leukemia
C) Breast cancer
D) Lung cancer
E) Salivary gland carcinoma

Question 12

Pseudomyxoma peritonei is a complication of which tumor?

A) Serous cystadenoma of the ovary
B) Mucinous cystadenoma of the ovary
C) Ovarian fibroma
D) Myxoma of the heart
E) Myxosarcoma of the lower extremity

Question 13

Homogeneous staining regions (HSR) of chromosome 2p, the site of the N-mycgene, are adverse prognostic signs if found in neuroblastoma cells. HRS are evidence of gene

A) deletion
B) amplification
C) point mutation
D) translocation
E) inversion

Question 14

In which cell function is BRCA1, a gene mutated in women with familial breast carcinoma, involved?

A) Cell adhesion
B) Growth inhibition
C) Signal transduction
D) Cell surface channel
E) Transcriptional regulation and DNA repair