Deck 5: B Cell Activation and Antibody Production

Question 1

For each of descriptions in questions , select the letter of the Ig isotype (A-E) that most closely matches it.
Answers may be used more than once.
An allergy attack

A)IgM
B)IgD
C)IgG
D)IgE
E)IgA

Answer 1

IgE

Question 2

Which one of the following statements about humoral immune responses is true?

A) Naive B cells are required for initiation of primary responses and memory B cells are required for initiation of secondary responses.
B) Antibody responses to bacterial polysaccharide antigens require CD4+ helper T cells.
C) Heavy chain isotype switching typically occurs in response to bacterial polysaccharide antigens.
D) Affinity maturation does not require helper T cells.
E) Antibody-secreting cells generated during a humoral immune response live for only a few hours.

Answer 2

Naive B cells are required for initiation of primary responses and memory B cells are required for initiation of secondary responses.

Question 3

For each of descriptions in questions , select the letter of the Ig isotype (A-E) that most closely matches it.
Answers may be used more than once.
T cell-independent antigens

A)IgM
B)IgD
C)IgG
D)IgE
E)IgA

Answer 3

IgM

Question 4

Which one of the following statements about primary and secondary antibody responses is NOT true?

A) Antibodies in primary responses generally have lower affinity for antigen than those produced in secondary responses.
B) Secondary responses reach peak levels more quickly than primary responses.
C) Primary responses require higher concentrations of antigen for initiation than secondary responses.
D) Primary responses occur to all types of antigens, but secondary responses mostly occur only to protein antigens.
E) Primary responses are characterized by IgG antibodies, whereas secondary responses are dominated by IgM antibodies.

Question 5

For each of descriptions in questions , select the letter of the Ig isotype (A-E) that most closely matches it.
Answers may be used more than once.
Unclear functional role

A)IgM
B)IgD
C)IgG
D)IgE
E)IgA

Question 6

For each of descriptions in questions , select the letter of the Ig isotype (A-E) that most closely matches it.
Answers may be used more than once.
Phagocytosis

A)IgM
B)IgD
C)IgG
D)IgE
E)IgA

Question 7

Matching
For each of the descriptions in questions , select the B cell signaling molecule (A-I) that most closely matches it.
A protein that is the cell surface receptor for Epstein-Barr virus

A)Igα
B)Igβ
C)C3b
D)C3d
E)CR2
F)CD19
G)CD81
H)Fyn
I)Syk

Question 8

Matching
For each of the descriptions in questions , select the B cell signaling molecule (A-I) that most closely matches it.
An Src family kinase that phosphorylates ITAMs in the cytoplasmic tails of B cell receptor complex proteins

A)Igα
B)Igβ
C)C3b
D)C3d
E)CR2
F)CD19
G)CD81
H)Fyn
I)Syk

Question 9

Matching
For each of the descriptions in questions , select the B cell signaling molecule (A-I) that most closely matches it.
A protein tyrosine kinase homologous to Zap-70, which phosphorylates several adaptor proteins and enzymes

A)Igα
B)Igβ
C)C3b
D)C3d
E)CR2
F)CD19
G)CD81
H)Fyn
I)Syk

Question 10

Matching
For each of the descriptions in questions , select the B cell signaling molecule (A-I) that most closely matches it.
A protein that covalently binds to microbes and serves as a ligand for a coreceptor that enhances B cell responses to antigen

A)Igα
B)Igβ
C)C3b
D)C3d
E)CR2
F)CD19
G)CD81
H)Fyn
I)Syk

Question 11

For each of descriptions in questions , select the letter of the Ig isotype (A-E) that most closely matches it.
Answers may be used more than once.
Binds to receptors in the gastrointestinal tract of infants for absorption into the serum

A)IgM
B)IgD
C)IgG
D)IgE
E)IgA