Deck 9: Cytokines

Question 1

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
Expressed on macrophages and B lymphocytes, this receptor plays an important role in the helper T cell-mediated effector functions.

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin

Answer 1

CD40

Question 2

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
Produced by T cells and binds to the same receptors as does TNF-a produced by macrophages

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin

Answer 2

Lymphotoxin

Question 3

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it.
Stimulates expression of class II MHC on various cell types

A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)Lymphotoxin

Answer 3

Interferon-g

Question 4

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
Expressed on osteoclasts, this receptor is important in remodeling bone.

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin

Question 5

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
Expressed as a membrane molecule on the surface of activated T cells, it binds to a receptor found on many cell types, including T cells, and induces apoptosis.

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin

Question 6

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
Expressed on many cells types, its cytoplasmic tail includes a death domain, binds TNF-receptor associated death domain (TRADD), and initiates a pro-apoptotic signaling cascade.

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin

Question 7

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
Important in dendritic cell and T cell localization in lymph nodes

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)

Question 8

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it.
Induces B cell isotype switching to IgE production

A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)Lymphotoxin

Question 9

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
Important mediator of inflammatory component of immediate hypersensitivity reactions

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)

Question 10

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it.
Inhibits proliferation and differentiation of T cells and the activation of macrophages

A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)Lymphotoxin

Question 11

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it.
Stimulates growth and activation of eosinophils

A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)Lymphotoxin

Question 12

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
Binds to interleukin-8

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)

Question 13

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
Binds chemokines important in T cell recruitment into peripheral inflammatory sites

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)

Question 14

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
Mediates neutrophil recruitment into tissues

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)