Deck 14: Immediate Hypersensitivity

Question 1

Matching
Match the definitions in questions with the mast cell mediator (A-G) that most closely matches it.
Protein constituent of granules that contributes to tissue damage in immediate hypersensitivity reactions

A)Histamine
B)Tryptase
C)Prostaglandin D₂
D)Leukotriene C₄
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Answer 1

Tryptase

Question 2

Matching
Match the definitions in questions with the mast cell mediator (A-G) that most closely matches it.
Lipoxygenase-pathway product of arachidonic acid metabolism that causes prolonged bronchoconstriction, mucus secretion, and increased vascular permeability

A)Histamine
B)Tryptase
C)Prostaglandin D₂
D)Leukotriene C₄
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Answer 2

Leukotriene C₄

Question 3

Which of the following is the most common disorder of immunity that affects 20% of all individuals in the United States?

A) Atopy
B) Diabetes mellitus
C) Leukemia
D) IgA deficiency
E) Latent tuberculosis infection

Answer 3

Atopy

Question 4

Matching
Match the definitions in questions with the mast cell mediator (A-G) that most closely matches it.
Biogenic amine that transiently increases vascular permeability and smooth muscle contraction

A)Histamine
B)Tryptase
C)Prostaglandin D₂
D)Leukotriene C₄
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Question 5

All of the following are key mediators of immediate hypersensitivity reactions EXCEPT:

A) Mast cells
B) Basophils
C) IgE
D) Macrophages
E) TH2 cells

Question 6

Matching
Match the definitions in questions with the mast cell mediator (A-G) that most closely matches it.
Cyclooxygenase-pathway product of arachidonic acid metabolism that causes vascular dilatation, smooth muscle contraction, and neutrophil chemotaxis

A)Histamine
B)Tryptase
C)Prostaglandin D₂
D)Leukotriene C₄
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Question 7

Matching
Match the definitions in questions with the mast cell mediator (A-G) that most closely matches it.
Soluble factor that promotes eosinophil maturation and activation

A)Histamine
B)Tryptase
C)Prostaglandin D₂
D)Leukotriene C₄
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Question 8

Immediate hypersensitivity differs from delayed-type hypersensitivity in which one of the following ways?

A) Immediate hypersensitivity is a CD4⁺ T cell-mediated disease.
B) Immediate hypersensitivity does not require previous exposure to an antigen.
C) Immediate hypersensitivity does not involve inflammation.
D) Immediate hypersensitivity is driven by cytokines such as interleukin (IL)-4, IL-5, and IL-13.
E) Immediate hypersensitivity typically leads to granuloma formation.

Question 9

Matching
Match the definitions in questions with the mast cell mediator (A-G) that most closely matches it.
Soluble factor that promotes inflammation and late-phase reaction and activates endothelial expression of adhesion molecules critical for sequential neutrophilic infiltrate

A)Histamine
B)Tryptase
C)Prostaglandin D₂
D)Leukotriene C₄
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Question 10

Matching
Match the definitions in questions with the mast cell mediator (A-G) that most closely matches it.
Membrane phospholipid derivative that causes bronchoconstriction, retraction of endothelial cells, and relaxation of vascular smooth muscle

A)Histamine
B)Tryptase
C)Prostaglandin D₂
D)Leukotriene C₄
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a