Deck 16: Immunologic Tolerance

Question 1

Immunologic tolerance is defined as:

A) The removal of an antigen, or the microbes expressing the antigen, by the immune system, so that the host can tolerate the infection
B) Activation of only B cells, and not T cells, on exposure to an antigen
C) Unresponsiveness of the immune system to an antigen, which is induced by previous exposure to that antigen
D) The production of memory B cells and T cells on primary exposure to an antigen, which allows the host to tolerate a secondary exposure to the antigen
E) Vaccination of individuals against particular pathogens to prevent subsequent infections

Answer 1

Unresponsiveness of the immune system to an antigen, which is induced by previous exposure to that antigen

Question 2

Matching
For each feature of self-tolerance described in questions , choose the term (letters A-K) that most closely matches it.
Mechanism of central tolerance of B cells

A)Immature (IgM⁺IgD^-)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4⁺CD8⁺)
J)Anergy
K)Thymic medulla

Answer 2

Receptor editing

Question 3

Matching
For each feature of self-tolerance described in questions , choose the term (letters A-K) that most closely matches it.
Site of central T cell tolerance induction

A)Immature (IgM⁺IgD^-)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4⁺CD8⁺)
J)Anergy
K)Thymic medulla

Answer 3

Thymic cortex

Question 4

Failure of self-tolerance is the cause of which one of the following types of diseases?

A) Allograft rejection
B) Autoimmunity
C) Atopy
D) Anergy
E) Acne

Question 5

Matching
For each feature of self-tolerance described in questions , choose the term (letters A-K) that most closely matches it.
Mechanism of peripheral tolerance for T cells but not B cells

A)Immature (IgM⁺IgD^-)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4⁺CD8⁺)
J)Anergy
K)Thymic medulla

Question 6

Matching
For each feature of self-tolerance described in questions , choose the term (letters A-K) that most closely matches it.
Tolerance-sensitive stage of T cell maturation

A)Immature (IgM⁺IgD^-)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4⁺CD8⁺)
J)Anergy
K)Thymic medulla

Question 7

Matching
For each feature of self-tolerance described in questions , choose the term (letters A-K) that most closely matches it.
Tolerance-sensitive stage of B cell maturation

A)Immature (IgM⁺IgD^-)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4⁺CD8⁺)
J)Anergy
K)Thymic medulla

Question 8

Matching
For each feature of self-tolerance described in questions , choose the term (letters A-K) that most closely matches it.
Mechanism of peripheral tolerance of B cells and T cells

A)Immature (IgM⁺IgD^-)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4⁺CD8⁺)
J)Anergy
K)Thymic medulla

Question 9

Matching
For each feature of self-tolerance described in questions , choose the term (letters A-K) that most closely matches it.
Mechanism of peripheral tolerance induction of B cells but not T cells

A)Immature (IgM⁺IgD^-)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4⁺CD8⁺)
J)Anergy
K)Thymic medulla

Question 10

Which of the following statements about induction or maintenance of T cell tolerance is NOT true?

A) Central tolerance is induced when immature developing T cells in bone marrow or thymus encounter self antigens.
B) Peripheral T cell tolerance results when mature naive T cells recognize antigens without adequate B7-1- or B7-2-mediated costimulation.
C) Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen.
D) Peripheral T cell tolerance to some antigens is induced when mature T cells recognize antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor.
E) Peripheral T cell tolerance to an antigen may be induced by persistent and repeated stimulation of lymphocytes by that antigen in tissues.