Deck 3: Immunogenicity and Antigenicity

Question 1

RhoGAM administered to an Rh-negative mother would help the patient by:
I- Preventing production of anti-Rh antibodies
II- Preventing fetal hemolysis in future pregnancies
III- Preventing transfusion reactions due to ABO mismatch

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Answer 1

I and II

Question 2

Which of the following is an example of an endogenous antigen?

A) Viral protein
B) Fungal cell wall
C) Protein exotoxins
D) Bacterial endotoxin

Answer 2

Viral protein

Question 3

Which of the following drugs can react with red blood cells (RBCs) to cause hemolysis?

A) Penicillin
B) Tetracycline
C) Tolbutamide
D) Procainamide

Answer 3

Procainamide

Question 4

Isoantigens found on red blood cells (RBCs) may lead to a hemolytic transfusion reaction because:

A) CD4⁺ T cells and macrophages mediate an inflammatory response
B) Individuals have antibodies to the ABO antigens they do not express
C) CD8⁺ T cells recognize the isoantigens as foreign and destroy the RBC
D) The isoantigens are metabolized to reactive metabolites that cause an allergic reaction

Question 5

Genetic factors that influence immunogenicity include:
I- Decreased functional capacity of the immune system over time
II- Lack of a T cell clone with a TCR that reacts to the antigen
III- Defect in antigen processing and antigen presentation

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Question 6

Production of a neoantigen would result from:

A) Fungal infection
B) Genetic mutation
C) Presence of endotoxins
D) Processing of parasitic antigens

Question 7

Which of the following represents a conformational epitope?

A) A mannose residue
B) Primary sequence of a short peptide
C) Long chain carbon segment of a lipid
D) Segment of two neighboring loops of a hemoglobin molecule

Question 8

How would you treat a mother with type A Rh-negative blood who is pregnant with a type O Rh-positive baby?

A) A dose of RhoGAM at 28 weeks and following delivery
B) A high dose of RhoGAM and then a low dose of RhoGAM
C) A dose of RhoGAM only if there is a trauma or premature termination of pregnancy
D) RhoGAM is not necessary in this situation because there is no compatibility issue

Question 9

When a low molecular weight (<3000 Da) pharmaceutical agent binds to albumin, the pharmaceutical agent is acting as a/an:

A) Hapten
B) Allergen
C) Immunogen
D) Carrier protein

Question 10

Which of the following would be considered the best immunogen?

A) Mannose
B) Viral DNA
C) Surface protein on a parasite
D) Lipid components of fungal membrane