Deck 8: B Cell Activation and Signaling

Question 1

X-linked agammaglobulinemia results from a defect in:

A) IL-7 gene
B) BTK gene
C) BLyS gene
D) CD22 gene

Answer 1

BTK gene

Question 2

Long-lived plasma cells are most likely to be produced in response to:

A) Thymic-dependent antigens
B) Type I thymic-independent antigens
C) Type II thymic-independent antigens
D) Both thymic-dependent and thymic-independent antigens result in production of long-lived plasma cells

Answer 2

Thymic-dependent antigens

Question 3

Which of the following is an example of a type I thymus-independent antigen?

A) Bacterial enzyme
B) Viral protein coat
C) Lipopolysaccharide (LPS)
D) Pneumococcal capsular polysaccharide

Answer 3

Lipopolysaccharide (LPS)

Question 4

What is the function of the BCR co-receptor complex?

A) Stimulate isotype switching
B) Binding to antigen presenting cells (APCs)
C) Crosslinking of BCRs for signal amplification
D) Recruitment of adaptor proteins to carry signal to nucleus

Question 5

Most long-lived plasma cells reside in the:

A) Spleen
B) Thymus
C) Lymph node
D) Bone marrow

Question 6

Which of the following are components of the BCR co-receptor complex?
I. CR2
II. CD19
III. CD22

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Question 7

Belimumab is a monoclonal antibody directed against:

A) BLyS
B) CD22
C) Bruton's kinase
D) BLyS and APRIL

Question 8

The phosphorylated immuno-receptor tyrosine-based activation motifs (ITAMs) of the BCR serve as a docking site for what adaptor protein?

A) Syk
B) NFAT
C) ZAP-70
D) Src kinase

Question 9

Which two cytokines are the main stimuli for B cell differentiation into plasma cells?

A) TNF and IL-1
B) TACI and BLyS
C) BLyS and APRIL
D) TLR-4 and Lipid A

Question 10

Why is crosslinking of BCRs important for B cell activation?
I. Crosslinking of BCRs allows for antigen presenting cells to bind to B cells
II. Crosslinking of BCRs must occur before the BCRs can bind to their matching antigen
III. Crosslinking of BCRs properly positions signaling molecules to carry the signal deeper into the cytoplasm

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III