Deck 17: Development of the Reproductive System

Question 1

Mutations in particular genes can cause or increase the risk of specific congenital anomalies of the urogenital system.Which gene when mutated is most likely to be responsible for male pseudohermaphrodism?

A) CFTR
B) AMH RECEPTOR
C) WT1
D) 5α-REDUCTASE
E) PDK1

Answer 1

D

Question 2

What effect would a loss of Shh expression within the urethral plate have on genital development?

A) Development of enlarged genital tubercle
B) Hypospadia
C) An increase in Hoxa13 and Hoxd3 expression in the genital tubercle
D) An increase in Fgf8 expression in the urethral plate

Answer 2

B

Question 3

Mutations in particular genes can cause or increase the risk of specific congenital anomalies of the urogenital system.Which gene when mutated is most likely to be responsible for persistent müllerian syndrome?

A) CFTR
B) AMH RECEPTOR
C) WT1
D) 5α-REDUCTASE
E) PDK1

Answer 3

B

Question 4

Mutations in particular genes can cause or increase the risk of specific congenital anomalies of the urogenital system.Which gene when mutated is most likely to be responsible for congenital bilateral aplasia of the vas deferens?

A) CFTR
B) AMH RECEPTOR
C) WT1
D) 5α-REDUCTASE
E) PDK1

Question 5

What gene is thought to be a direct downstream target of SRY expression?

A) SOX9
B) WF1
C) AMH
D) DESERT HEDGEHOG
E) WNT4