Deck 11: Development of the Peripheral Nervous System

Question 1

A child is diagnosed with congenital insensitivity to pain with anhidrosis.The receptor for which growth factor is mutated in this condition?

A) Epidermal growth factor
B) Transforming growth factor beta
C) Scatter factor
D) Fibroblast growth factor
E) Nerve growth factor

Answer 1

E

Question 2

Hereditary peripheral neuropathies,such as Charcot-Marie-Tooth hereditary neuropathy,involve nerve demyelination.What cell type myelinates peripheral nerves during development?

A) Schwann cells
B) Oligodendrocytes
C) Astrocytes
D) Chromaffin cells
E) Endothelial cells

Answer 2

A

Question 3

Neurogenesis in the PNS involves both positive and negative regulators.Which signaling pathway plays an essential role as a negative regulator of neurogenesis?

A) Tyrosine kinase
B) Tgfbeta
C) Integrin
D) Ephrin-Eph
E) Notch-Delta

Answer 3

E

Question 4

A researcher labels the second epibranchial placodes.Cells of what structure(s)will be labeled later in development?

A) Olfactory nerve
B) Vestibulocochlear nerve
C) Superior ganglion
D) Petrosal ganglion
E) Enteric ganglia

Question 5

A patient is diagnosed with neurofibromatosis type 1.What type of gene is mutated in this condition?

A) Transcription factor
B) Growth factor
C) Extracellular adhesion molecule
D) Tumor suppressor gene
E) Cytoskeletal protein