Deck 4: Nucleic Acids and the Origin of Life
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Deck 4: Nucleic Acids and the Origin of Life
1
Which is an example of a nucleotide?
A)
B)
C)
D)
E)
A)

B)

C)

D)

E)

C
2
Ribose and deoxyribose are both found in nucleic acids.The difference between ribose and deoxyribose is that
A) deoxyribose has one more oxygen atom than ribose.
B) ribose is a pentose sugar, whereas deoxyribose is a hexose sugar.
C) deoxyribose forms a six-membered ring, whereas ribose forms a five-membered ring.
D) ribose has a higher molecular weight than deoxyribose because of its extra hydroxyl group.
E) deoxyribose bonds to purines, whereas ribose bonds to pyrimidines.
A) deoxyribose has one more oxygen atom than ribose.
B) ribose is a pentose sugar, whereas deoxyribose is a hexose sugar.
C) deoxyribose forms a six-membered ring, whereas ribose forms a five-membered ring.
D) ribose has a higher molecular weight than deoxyribose because of its extra hydroxyl group.
E) deoxyribose bonds to purines, whereas ribose bonds to pyrimidines.
D
3
All of the following bases are found in DNA except
A) thymine.
B) adenine.
C) uracil.
D) guanine.
E) cytosine.
A) thymine.
B) adenine.
C) uracil.
D) guanine.
E) cytosine.
C
4
In DNA, bonding of A with T and bonding of C with G are examples of
A) complementary base pairing.
B) a dehydration reaction.
C) a reduction reaction.
D) a hydrophobic interaction.
E) a purine-purine interaction.
A) complementary base pairing.
B) a dehydration reaction.
C) a reduction reaction.
D) a hydrophobic interaction.
E) a purine-purine interaction.
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5
Single-stranded RNA can fold back on itself, creating three-dimensional structures such as tRNA.The folds are stabilized by _______ bonds.
A) hydrogen
B) ionic
C) phosphodiester
D) peptide
E) glycosidic
A) hydrogen
B) ionic
C) phosphodiester
D) peptide
E) glycosidic
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6
DNA utilizes the bases guanine, cytosine, thymine, and adenine.In RNA, _______ is replaced by _______.
A) adenine; arginine
B) thymine; uracil
C) cytosine; uracil
D) cytosine; arginine
E) cytosine; thymine
A) adenine; arginine
B) thymine; uracil
C) cytosine; uracil
D) cytosine; arginine
E) cytosine; thymine
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7
According to the principle of complementary base pairing, purines always pair with
A) deoxyribose sugars.
B) uracil.
C) pyrimidines.
D) adenine.
E) guanine.
A) deoxyribose sugars.
B) uracil.
C) pyrimidines.
D) adenine.
E) guanine.
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8
What type of bond connects two complementary nucleotides?
A) Hydrogen
B) Ionic
C) Peptide
D) Phosphodiester
E) Covalent
A) Hydrogen
B) Ionic
C) Peptide
D) Phosphodiester
E) Covalent
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9
Complementary base pairing occurs due to
A) covalent bonds between bases.
B) pairing of a purine with a pyrimidine.
C) hydrophobic interactions.
D) hydrogen bonds between sugar residues.
E) pairing of two purines or two pyrimidines.
A) covalent bonds between bases.
B) pairing of a purine with a pyrimidine.
C) hydrophobic interactions.
D) hydrogen bonds between sugar residues.
E) pairing of two purines or two pyrimidines.
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10
DNA differs from RNA in that
A) RNA contains thymine whereas DNA contains uracil.
B) base pairing is only possible between strands of DNA.
C) only DNA is present in the cell nucleus.
D) RNA contains pentose sugar residues whereas DNA contains hexose sugar residues.
E) only DNA has an equal number of purines and pyrimidines.
A) RNA contains thymine whereas DNA contains uracil.
B) base pairing is only possible between strands of DNA.
C) only DNA is present in the cell nucleus.
D) RNA contains pentose sugar residues whereas DNA contains hexose sugar residues.
E) only DNA has an equal number of purines and pyrimidines.
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11
The "backbone" of a nucleic acid molecule is made of
A) nitrogenous bases.
B) alternating sugar and phosphate groups.
C) purines.
D) pyrimidines.
E) nucleosides.
A) nitrogenous bases.
B) alternating sugar and phosphate groups.
C) purines.
D) pyrimidines.
E) nucleosides.
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12
A nucleotide contains a pentose sugar, a phosphate group, and a(n)
A) lipid.
B) acid.
C) nitrogen-containing base.
D) amino acid.
E) glycerol.
A) lipid.
B) acid.
C) nitrogen-containing base.
D) amino acid.
E) glycerol.
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13
Suppose you obtain four different samples of nucleic acids.You analyze the nitrogenous base composition of each one and get the results in the table below (the numbers indicate percentage of each nitrogenous base in the samples).
Which of these nucleic acids is/are single-stranded RNA?
A) A
B) B
C) C
D) D
E) Both C and D

A) A
B) B
C) C
D) D
E) Both C and D
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14
Nucleotides in RNA are connected to one another in the polynucleotide chain by _______ bonds between _______.
A) hydrogen; a sugar and a phosphate group
B) covalent; two phosphates
C) covalent; two sugars
D) hydrogen; two phosphate groups
E) covalent; a sugar and a phosphate group
A) hydrogen; a sugar and a phosphate group
B) covalent; two phosphates
C) covalent; two sugars
D) hydrogen; two phosphate groups
E) covalent; a sugar and a phosphate group
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15
Which of the following statements about DNA and RNA is true?
A) DNA has uracil, whereas RNA has thymine.
B) DNA usually has one polynucleotide strand, whereas RNA usually has two strands.
C) DNA contains pentose sugars, whereas RNA contains hexose sugars.
D) DNA is a polymer, whereas RNA is a monomer.
E) In DNA, A pairs with T, whereas in RNA, A pairs with U.
A) DNA has uracil, whereas RNA has thymine.
B) DNA usually has one polynucleotide strand, whereas RNA usually has two strands.
C) DNA contains pentose sugars, whereas RNA contains hexose sugars.
D) DNA is a polymer, whereas RNA is a monomer.
E) In DNA, A pairs with T, whereas in RNA, A pairs with U.
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16
What is the nucleotide sequence of the complementary strand of the following DNA molecule: AATGCGA?
A) TTACGCT
B) AATGCGA
C) GGCATAG
D) CCGTTAT
E) AGCGTAA
A) TTACGCT
B) AATGCGA
C) GGCATAG
D) CCGTTAT
E) AGCGTAA
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17
The bases of nucleic acids are purines or pyrimidines.Which statement contrasting purines and pyrimidines is true?
A) Purines include the bases cytosine and thymine, whereas pyrimidines include the bases adenine and guanine.
B) Pyrimidines are found in RNA, whereas purines are found in DNA.
C) Purines are double-ring structures, whereas pyrimidines are single-ring structures.
D) Purines have only single bonds in their structure, whereas pyrimidines have both single and double bonds in their structure.
E) Purines consist of hydrogen, carbon, oxygen, and nitrogen, whereas pyrimidines have phosphorus, hydrogen, carbon, oxygen, and nitrogen.
A) Purines include the bases cytosine and thymine, whereas pyrimidines include the bases adenine and guanine.
B) Pyrimidines are found in RNA, whereas purines are found in DNA.
C) Purines are double-ring structures, whereas pyrimidines are single-ring structures.
D) Purines have only single bonds in their structure, whereas pyrimidines have both single and double bonds in their structure.
E) Purines consist of hydrogen, carbon, oxygen, and nitrogen, whereas pyrimidines have phosphorus, hydrogen, carbon, oxygen, and nitrogen.
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18
The four nitrogenous bases of RNA are abbreviated as
A) A, G, C, and T.
B) A, G, T, and N.
C) A, G, C, and U.
D) A, G, U, and T.
E) G, C, U, and N.
A) A, G, C, and T.
B) A, G, T, and N.
C) A, G, C, and U.
D) A, G, U, and T.
E) G, C, U, and N.
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19
Which factor contributes to the strength of the intermolecular interaction between two DNA strands in a double helix?
A) Hydrogen bonds between purines and pyrimidines
B) Phosphodiester bonds between the nitrogenous bases
C) Strong hydrogen bonds between the sugar and phosphate groups
D) Its double-helix shape
E) The direct bonding of the base to the phosphate molecule
A) Hydrogen bonds between purines and pyrimidines
B) Phosphodiester bonds between the nitrogenous bases
C) Strong hydrogen bonds between the sugar and phosphate groups
D) Its double-helix shape
E) The direct bonding of the base to the phosphate molecule
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20
What is attached to the 5ʹ carbon of deoxyribose in DNA?
A) Adenine
B) Phosphate
C) Guanine
D) Thymine
E) Uracil
A) Adenine
B) Phosphate
C) Guanine
D) Thymine
E) Uracil
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21
In the DNA double helix, the bases in one strand are complementary to the bases in the other strand.Therefore,
A) a purine in one strand will attach to any pyrimidine in the other strand.
B) the bases in one strand will be the same as those of the other strand.
C) a pyrimidine in one strand will attach to any pyrimidine in the other strand.
D) a purine in one strand will attach to a different purine in the other strand.
E) a purine in one strand will attach to only one type of pyrimidine in the other strand.
A) a purine in one strand will attach to any pyrimidine in the other strand.
B) the bases in one strand will be the same as those of the other strand.
C) a pyrimidine in one strand will attach to any pyrimidine in the other strand.
D) a purine in one strand will attach to a different purine in the other strand.
E) a purine in one strand will attach to only one type of pyrimidine in the other strand.
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22
Which statement concerning genetic information in most cells is true?
A) The entire DNA molecule is copied to RNA during DNA replication.
B) A single DNA nucleotide codes for a single amino acid.
C) The flow of information in a cell is from DNA to RNA to protein.
D) The flow of information in a cell is from protein to RNA to DNA.
E) The flow of information in a cell is from DNA to protein to RNA.
A) The entire DNA molecule is copied to RNA during DNA replication.
B) A single DNA nucleotide codes for a single amino acid.
C) The flow of information in a cell is from DNA to RNA to protein.
D) The flow of information in a cell is from protein to RNA to DNA.
E) The flow of information in a cell is from DNA to protein to RNA.
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23
Which statement about DNA base sequences is true?
A) The more distant the evolutionary relationship between two species, the greater the similarity in their DNA base sequences.
B) Comparisons of DNA base sequences cannot be used to make inferences about the evolutionary relatedness of two species.
C) The chimpanzee and human genomes share 18 percent of their DNA base sequences.
D) Evolutionary relationships between species are more accurately determined by DNA base sequence analysis than by comparisons of physical or behavioral characteristics.
E) The human genome contains only part of the biological information present in the human body.
A) The more distant the evolutionary relationship between two species, the greater the similarity in their DNA base sequences.
B) Comparisons of DNA base sequences cannot be used to make inferences about the evolutionary relatedness of two species.
C) The chimpanzee and human genomes share 18 percent of their DNA base sequences.
D) Evolutionary relationships between species are more accurately determined by DNA base sequence analysis than by comparisons of physical or behavioral characteristics.
E) The human genome contains only part of the biological information present in the human body.
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24
The copying of a DNA sequence to make an RNA sequence is called
A) catalysis.
B) replication.
C) translation.
D) transcription.
E) expression.
A) catalysis.
B) replication.
C) translation.
D) transcription.
E) expression.
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25
Refer to the figure below showing two strands of DNA.
Which statement about uracil can you infer to be true?
A) It has a double ring and forms two hydrogen bonds.
B) It has a single ring and forms two hydrogen bonds.
C) It has a double ring and forms three hydrogen bonds.
D) It has a single ring and forms three hydrogen bonds.
E) It has a single ring and forms one hydrogen bond.

A) It has a double ring and forms two hydrogen bonds.
B) It has a single ring and forms two hydrogen bonds.
C) It has a double ring and forms three hydrogen bonds.
D) It has a single ring and forms three hydrogen bonds.
E) It has a single ring and forms one hydrogen bond.
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26
Which statement about DNA or RNA is true?
A) DNA is completely replicated but only partially transcribed.
B) DNA is partially replicated but completely transcribed.
C) RNA is completely replicated but only partially translated.
D) DNA is completely replicated and completely translated.
E) DNA is partially replicated but completely translated.
A) DNA is completely replicated but only partially transcribed.
B) DNA is partially replicated but completely transcribed.
C) RNA is completely replicated but only partially translated.
D) DNA is completely replicated and completely translated.
E) DNA is partially replicated but completely translated.
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27
If there is an exposed purine during DNA replication,
A) any purine will be joined to it.
B) a specific purine will be joined to the exposed purine, depending on which purine is exposed.
C) a specific pyrimidine will be joined to the exposed purine, depending on which purine it is.
D) any pyrimidine will be joined to it.
E) a phosphate group will be joined to the exposed purine.
A) any purine will be joined to it.
B) a specific purine will be joined to the exposed purine, depending on which purine is exposed.
C) a specific pyrimidine will be joined to the exposed purine, depending on which purine it is.
D) any pyrimidine will be joined to it.
E) a phosphate group will be joined to the exposed purine.
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28
If pyrimidines could bind to other pyrimidines, and purines could bind to other purines, what would be the effect on the DNA double helix?
A) The width of the double helix would vary rather than being fixed.
B) The phosphodiester bonds would be unable to form.
C) There would be a reduced requirement for phosphates in nucleotides.
D) The DNA backbone would be made of nucleosides.
E) The sugar would have to be ribose instead of deoxyribose.
A) The width of the double helix would vary rather than being fixed.
B) The phosphodiester bonds would be unable to form.
C) There would be a reduced requirement for phosphates in nucleotides.
D) The DNA backbone would be made of nucleosides.
E) The sugar would have to be ribose instead of deoxyribose.
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29
Nucleic acids and proteins are both polymers made of a set of monomers.Complete the following analogy: _______ are to nucleotides as side chains are to amino acids.
A) ribose/deoxyribose sugars
B) phosphate ions
C) nitrogenous bases
D) nucleosides
E) hydroxyl groups
A) ribose/deoxyribose sugars
B) phosphate ions
C) nitrogenous bases
D) nucleosides
E) hydroxyl groups
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30
Consider the following double-stranded DNA region: 5ʹ-TGCCAT-3ʹ
3ʹ-ACGGTA-5ʹ
If the lower strand is transcribed, which strand will result?
A) TGCCAT
B) TCGGTA
C) UGCCAU
D) UGCCUA
E) TCGGUT
3ʹ-ACGGTA-5ʹ
If the lower strand is transcribed, which strand will result?
A) TGCCAT
B) TCGGTA
C) UGCCAU
D) UGCCUA
E) TCGGUT
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31
With a few exceptions, each human cell contains DNA in its nucleus.Which statement about any cell containing DNA is true?
A) The entire genome is expressed in each cell.
B) The cell discards some of its DNA so that only genes with a function in that cell are retained.
C) Cells synthesize RNA transcripts from its DNA before discarding the DNA.
D) Different genes may be expressed at different times in a single cell.
E) Cell functioning differs depending on the DNA present in the cell.
A) The entire genome is expressed in each cell.
B) The cell discards some of its DNA so that only genes with a function in that cell are retained.
C) Cells synthesize RNA transcripts from its DNA before discarding the DNA.
D) Different genes may be expressed at different times in a single cell.
E) Cell functioning differs depending on the DNA present in the cell.
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32
Complementary base pairing between nucleotides makes which process possible?
A) Hydrolysis of DNA
B) Formation of phosphodiester bonds in polynucleotides
C) DNA replication prior to cell division
D) Movement of mRNA from nucleus to cytoplasm
E) Biosynthesis of nucleotide building blocks by a cell
A) Hydrolysis of DNA
B) Formation of phosphodiester bonds in polynucleotides
C) DNA replication prior to cell division
D) Movement of mRNA from nucleus to cytoplasm
E) Biosynthesis of nucleotide building blocks by a cell
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33
What is the sequence of the complementary strand of RNA made from this template sequence? 5ʹ-AGC TTC GCT GAA GCT CGG-3ʹ
(Note: The spaces between the nucleotides have been inserted in order to make the sequence easier to read.)
A) 5ʹ-UCG AAG CGA CUU CGA GCC-5ʹ
B) 3ʹ-UCG AAG CGA CUU CGA GCC-5ʹ
C) 3ʹ-TCG AAG CGA CTT CGA GCC-5ʹ
D) 5ʹ-GGC TCG AAG TCG CTT CGA-5ʹ
E) 5ʹ-TCG AAG CGA CTT CGA GCC-3ʹ
(Note: The spaces between the nucleotides have been inserted in order to make the sequence easier to read.)
A) 5ʹ-UCG AAG CGA CUU CGA GCC-5ʹ
B) 3ʹ-UCG AAG CGA CUU CGA GCC-5ʹ
C) 3ʹ-TCG AAG CGA CTT CGA GCC-5ʹ
D) 5ʹ-GGC TCG AAG TCG CTT CGA-5ʹ
E) 5ʹ-TCG AAG CGA CTT CGA GCC-3ʹ
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34
Refer to the figure below showing two strands of DNA.
How many hydrogen bonds would there be in a DNA sequence of ten base pairs in which there are five A-T and five C-G pairs?
A) 5
B) 10
C) 15
D) 25
E) 18

A) 5
B) 10
C) 15
D) 25
E) 18
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35
Complementary base pairing between strands of nucleic acids is limited to particular pairings because of
A) the relative sizes and shapes of purines and pyrimidines.
B) the alternating sugar-phosphate groups.
C) evolutionary relationships.
D) the differences found between RNA and DNA.
E) the diversity found in DNA molecules.
A) the relative sizes and shapes of purines and pyrimidines.
B) the alternating sugar-phosphate groups.
C) evolutionary relationships.
D) the differences found between RNA and DNA.
E) the diversity found in DNA molecules.
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36
The end product of transcription is _______, and the end product of translation is _______.
A) proteins; DNA
B) proteins; RNA
C) RNA; DNA
D) DNA; RNA
E) RNA; proteins
A) proteins; DNA
B) proteins; RNA
C) RNA; DNA
D) DNA; RNA
E) RNA; proteins
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37
Refer to the table below showing the percent overlap in genomic sequences between species pairs.
Which two species are most closely evolutionarily related, and which two are most distantly related?
A) Species A and D are most closely related, while species B and C are most distantly related.
B) Species B and C are most closely related, while species A and D are most distantly related.
C) Species A and B are most closely related, while species B and D are most distantly related.
D) Species C and D are most closely related, while species A and C are most distantly related.
E) Species A and B are most closely related, while species B and C are most distantly related.

A) Species A and D are most closely related, while species B and C are most distantly related.
B) Species B and C are most closely related, while species A and D are most distantly related.
C) Species A and B are most closely related, while species B and D are most distantly related.
D) Species C and D are most closely related, while species A and C are most distantly related.
E) Species A and B are most closely related, while species B and C are most distantly related.
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38
The double-stranded structure of DNA results from
A) hydrophobic interactions.
B) purines bonding with purines and pyrimidines bonding with pyrimidines.
C) the phosphodiester bonds between deoxyribose and phosphate.
D) hydrogen bonding within and between polynucleotide strands.
E) ionic bonding between base pairs.
A) hydrophobic interactions.
B) purines bonding with purines and pyrimidines bonding with pyrimidines.
C) the phosphodiester bonds between deoxyribose and phosphate.
D) hydrogen bonding within and between polynucleotide strands.
E) ionic bonding between base pairs.
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39
The diversity in DNA molecules is due to
A) physical shape differences.
B) differences in size between A-T and G-C base pairs.
C) base sequence differences.
D) hydrogen bonding differences.
E) the ability of each base to pair with any of the other three bases.
A) physical shape differences.
B) differences in size between A-T and G-C base pairs.
C) base sequence differences.
D) hydrogen bonding differences.
E) the ability of each base to pair with any of the other three bases.
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40
DNA carries genetic information in its
A) helical form.
B) sequence of bases.
C) tertiary sequence.
D) sequence of amino acids.
E) phosphate groups.
A) helical form.
B) sequence of bases.
C) tertiary sequence.
D) sequence of amino acids.
E) phosphate groups.
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41
Which is a plausible explanation for the presence of carbon dioxide in Earth's early atmosphere?
A) Volcanic eruptions could have released carbon dioxide into the atmosphere.
B) Cyanobacteria were present on Earth 3.5 billion years ago.
C) Retroviruses could have catalyzed the formation of carbon dioxide.
D) Geysers may have produced Earth's early environment.
E) Chemical reactions with water would have resulted in the formation of carbon dioxide.
A) Volcanic eruptions could have released carbon dioxide into the atmosphere.
B) Cyanobacteria were present on Earth 3.5 billion years ago.
C) Retroviruses could have catalyzed the formation of carbon dioxide.
D) Geysers may have produced Earth's early environment.
E) Chemical reactions with water would have resulted in the formation of carbon dioxide.
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42
In 1668, Francesco Redi conducted experiments to investigate the concept of spontaneous generation.He began by putting pieces of meat into identical jars.Some jars were left open to the air, some were sealed, and some were covered with gauze that kept out flies while allowing the meat to be exposed to the air.Redi then observed whether or not fly maggots appeared in the meat.What hypothesis was Redi testing?
A) Spontaneous generation is more likely to occur during the hot days of summer.
B) Maggots do not arise spontaneously, but from eggs laid by adult flies.
C) The type of meat affects whether spontaneous generation occurs.
D) Spontaneous generation can occur only if air is present.
E) Flies will develop from rotting meat if the meat is exposed to air.
A) Spontaneous generation is more likely to occur during the hot days of summer.
B) Maggots do not arise spontaneously, but from eggs laid by adult flies.
C) The type of meat affects whether spontaneous generation occurs.
D) Spontaneous generation can occur only if air is present.
E) Flies will develop from rotting meat if the meat is exposed to air.
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43
Refer to the figure below illustrating Louis Pasteur's experiment on spontaneous generation.
Why was the neck broken on one flask but not the other?
A) To ensure that conditions were the same in both experimental setups
B) To prevent contaminants from getting in through the neck
C) To allow dust to enter into the broken flask but not the unbroken one
D) To show that the neck of the flask does not introduce an added variable to the experiment
E) To allow air to enter the control flask

A) To ensure that conditions were the same in both experimental setups
B) To prevent contaminants from getting in through the neck
C) To allow dust to enter into the broken flask but not the unbroken one
D) To show that the neck of the flask does not introduce an added variable to the experiment
E) To allow air to enter the control flask
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44
The most likely source of early Earth's atmospheric oxygen was
A) volcanic eruptions.
B) lightning striking water vapor.
C) the spontaneous breakdown of fatty acids.
D) photosynthesis by ancient cyanobacteria (blue-green algae).
E) the decay of fossil organisms.
A) volcanic eruptions.
B) lightning striking water vapor.
C) the spontaneous breakdown of fatty acids.
D) photosynthesis by ancient cyanobacteria (blue-green algae).
E) the decay of fossil organisms.
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45
Changes to the original Miller‒Urey hot chemistry experiment included adding other gases like carbon dioxide (CO2), nitrogen (N2), hydrogen sulfide (H2S), and sulfur dioxide (SO2) in the test apparatus, which resulted in the production of more small molecules of life than the original experiment had produced. Which products were shown to be significant for the evolution of the cellular membrane?
A) All five bases that are present in nucleic acids (i.e., A, T, C, G, and U)
B) All of the 20 standard amino acids
C) Many 3- to 6-carbon sugars
D) Certain fatty acids
E) Small carboxylic acids
A) All five bases that are present in nucleic acids (i.e., A, T, C, G, and U)
B) All of the 20 standard amino acids
C) Many 3- to 6-carbon sugars
D) Certain fatty acids
E) Small carboxylic acids
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46
Miller and Urey's 1954 hot chemistry experiment was based on the assumption that Earth's early atmosphere contained water (H2O) vapor, methane, hydrogen, and ammonia.Subsequent research showed that volcanoes released carbon dioxide (CO2), hydrogen sulfide (H2S), and sulfur dioxide (SO2) around 4 billion years ago.This discovery suggests that
A) early small molecules of life may have been produced in volcanoes.
B) Earth's early environment included these gases as well.
C) these gases were toxic to early life forms.
D) volcanoes may have been responsible for the oxygen production once attributed to cyanobacteria.
E) prebiotic synthesis could not have occurred in ice, since volcanoes would have melted the ice.
A) early small molecules of life may have been produced in volcanoes.
B) Earth's early environment included these gases as well.
C) these gases were toxic to early life forms.
D) volcanoes may have been responsible for the oxygen production once attributed to cyanobacteria.
E) prebiotic synthesis could not have occurred in ice, since volcanoes would have melted the ice.
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47
A prerequisite for life as we know it on Earth or any other planet is
A) sunlight.
B) water.
C) amino acids.
D) nitrogen.
E) carbon dioxide.
A) sunlight.
B) water.
C) amino acids.
D) nitrogen.
E) carbon dioxide.
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48
Refer to the figure below illustrating Louis Pasteur's experiment on spontaneous generation.
The experiment supports which hypothesis?
A) Amino acids are the building blocks of life.
B) Some forms of life can arise by spontaneous generation.
C) Oxygen is needed for life.
D) Life comes from decaying matter.
E) Life comes from preexisting life.

A) Amino acids are the building blocks of life.
B) Some forms of life can arise by spontaneous generation.
C) Oxygen is needed for life.
D) Life comes from decaying matter.
E) Life comes from preexisting life.
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49
Miller and Urey's 1954 hot chemistry experiment was based on the assumption that Earth's early atmosphere contained water (H2O) vapor, methane, hydrogen, and ammonia.Subsequent research showed that volcanoes released carbon dioxide (CO2), hydrogen sulfide (H2S), and sulfur dioxide (SO2) around 4 billion years ago.In response to this evidence, scientists concluded that
A) no synthesis of prebiotic molecules was possible on early Earth.
B) the experiment needed to be repeated with the inclusion of CO2, SO2, and H2O.
C) the experiment needed to be repeated with the inclusion of CO2, SO2, and H2S.
D) the experiment needed to be repeated with the inclusion of CO2, SO2, and H2S, and the exclusion of the original gases.
E) the experiment needed to be repeated in the vicinity of an active volcano and with the inclusion of CO2, SO2, and H2S.
A) no synthesis of prebiotic molecules was possible on early Earth.
B) the experiment needed to be repeated with the inclusion of CO2, SO2, and H2O.
C) the experiment needed to be repeated with the inclusion of CO2, SO2, and H2S.
D) the experiment needed to be repeated with the inclusion of CO2, SO2, and H2S, and the exclusion of the original gases.
E) the experiment needed to be repeated in the vicinity of an active volcano and with the inclusion of CO2, SO2, and H2S.
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50
The French scientist Louis Pasteur showed that, under Earth's present conditions,
A) microorganisms can arise only from other microorganisms.
B) an environment with life will eventually become lifeless.
C) flies arise spontaneously from rotting meat.
D) air is necessary for microorganisms to grow.
E) boiling destroys microorganisms.
A) microorganisms can arise only from other microorganisms.
B) an environment with life will eventually become lifeless.
C) flies arise spontaneously from rotting meat.
D) air is necessary for microorganisms to grow.
E) boiling destroys microorganisms.
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51
Changes to the original Miller‒Urey hot chemistry experiment included adding other gases like carbon dioxide (CO2), nitrogen (N2), hydrogen sulfide (H2S), and sulfur dioxide (SO2) in the test apparatus, which resulted in the production of more small molecules of life than the original experiment had produced.Which products were shown to be significant for the synthesis of proteins?
A) All five bases that are present in nucleic acids (i.e., A, T, C, G, and U)
B) All of the 20 standard amino acids
C) Many 3- to 6-carbon sugars
D) Certain fatty acids
E) Small carboxylic acids
A) All five bases that are present in nucleic acids (i.e., A, T, C, G, and U)
B) All of the 20 standard amino acids
C) Many 3- to 6-carbon sugars
D) Certain fatty acids
E) Small carboxylic acids
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52
Examination of meteorites suggests that
A) prebiotic synthesis of small molecules of life is not limited to Earth.
B) simple life forms can live on meteorites.
C) comets brought Earth most of its water.
D) meteorites brought living cells to Earth.
E) meteorites are responsible for Earth's magnetic field.
A) prebiotic synthesis of small molecules of life is not limited to Earth.
B) simple life forms can live on meteorites.
C) comets brought Earth most of its water.
D) meteorites brought living cells to Earth.
E) meteorites are responsible for Earth's magnetic field.
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53
Which gas was a component of Earth's early atmosphere?
A) Argon
B) Neon
C) Water vapor
D) Oxygen
E) Freon
A) Argon
B) Neon
C) Water vapor
D) Oxygen
E) Freon
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54
Refer to the figure below diagramming a protein composed of two R subunits and two C subunits.The R subunits are identical and the C subunits are identical, but R and C differ from each other.
The figure depicts a nucleotide performing a function.How can this function be described?
A) Information storage
B) Information transfer
C) Energy metabolism
D) Biological activity regulation
E) Electron transfer

A) Information storage
B) Information transfer
C) Energy metabolism
D) Biological activity regulation
E) Electron transfer
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55
Why did the Miller‒Urey hot chemistry experiment exclude oxygen in its investigation of the chemical origin of life on Earth?
A) Oxygen is not necessary for life.
B) The scientists assumed the reactions would produce oxygen from water vapor.
C) The scientists assumed that photosynthetic organisms would develop in the apparatus.
D) There is no evidence that oxygen existed in Earth's earliest environments.
E) The scientists wanted to avoid contamination of the apparatus by oxygen-consuming bacteria.
A) Oxygen is not necessary for life.
B) The scientists assumed the reactions would produce oxygen from water vapor.
C) The scientists assumed that photosynthetic organisms would develop in the apparatus.
D) There is no evidence that oxygen existed in Earth's earliest environments.
E) The scientists wanted to avoid contamination of the apparatus by oxygen-consuming bacteria.
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56
In Stanley Miller's long-term cold chemistry experiment concerning prebiotic synthesis, test tubes containing ammonia gas, water vapor, and cyanide (HCN) were cooled to -78°C.When they were opened after 27 years, they contained amino acids and nucleotide bases.This result was interpreted to mean that
A) ice crystals served as templates for molecule formation.
B) the evolution of life would never have occurred on icy planets, because it happens too slowly.
C) ice on moons of Jupiter and Saturn may be environments for prebiotic synthesis.
D) cold temperatures are necessary for small molecule synthesis on other planets.
E) life could only have arisen under extremely cold conditions.
A) ice crystals served as templates for molecule formation.
B) the evolution of life would never have occurred on icy planets, because it happens too slowly.
C) ice on moons of Jupiter and Saturn may be environments for prebiotic synthesis.
D) cold temperatures are necessary for small molecule synthesis on other planets.
E) life could only have arisen under extremely cold conditions.
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57
The idea of spontaneous generation was disproved through experiments by
A) Stanley Miller.
B) Harold Urey.
C) Francesco Redi and Louis Pasteur.
D) Allan Hills.
E) Johannes van der Waals.
A) Stanley Miller.
B) Harold Urey.
C) Francesco Redi and Louis Pasteur.
D) Allan Hills.
E) Johannes van der Waals.
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58
After the discovery that volcanoes released carbon dioxide (CO2), hydrogen sulfide (H2S), and sulfur dioxide (SO2) into the atmosphere 4 billion years ago, scientists conducted the Miller‒Urey experiment with the inclusion of these gases.How did the results differ from the original results?
A) No small or large prebiotic molecules were produced.
B) DNA was produced.
C) All 20 amino acids used in protein synthesis were produced.
D) Living cells were produced.
E) Nonliving protocells were produced.
A) No small or large prebiotic molecules were produced.
B) DNA was produced.
C) All 20 amino acids used in protein synthesis were produced.
D) Living cells were produced.
E) Nonliving protocells were produced.
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59
The Miller-Urey experiment showed that in an environment with conditions similar to those of Earth,
A) inorganic molecules could react to form organic molecules.
B) RNA could self-replicate.
C) organic molecules could form primitive cells.
D) an oxygen atmosphere could develop.
E) DNA could be synthesized.
A) inorganic molecules could react to form organic molecules.
B) RNA could self-replicate.
C) organic molecules could form primitive cells.
D) an oxygen atmosphere could develop.
E) DNA could be synthesized.
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60
Which line of evidence supports the hypothesis that the prebiotic synthesis of molecules could occur in water inclusions within ice on celestial bodies such as Europa, a moon of Jupiter?
A) The internal structure of 3.5-billion-year-old fossilized spheres in Australian rocks
B) The synthesis of prebiotic molecules in a heated solution of gases treated with electrical sparks
C) The presence of frozen mammoths in frozen soil in the Yukon
D) The synthesis of prebiotic molecules in test tubes containing ammonia gas, water vapor, and cyanide (HCN) cooled to -78°C
E) The capacity of RNA to act as a catalyst
A) The internal structure of 3.5-billion-year-old fossilized spheres in Australian rocks
B) The synthesis of prebiotic molecules in a heated solution of gases treated with electrical sparks
C) The presence of frozen mammoths in frozen soil in the Yukon
D) The synthesis of prebiotic molecules in test tubes containing ammonia gas, water vapor, and cyanide (HCN) cooled to -78°C
E) The capacity of RNA to act as a catalyst
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61
Refer to the figure below illustrating the "RNA world" hypothesis.
Which statement about this hypothetical evolutionary model is true?
A) It supports the hypothesis that proteins appeared on Earth before nucleic acids.
B) It would be impossible in reality, since RNA is synthesized from DNA.
C) It would require prebiotic synthesis of fatty acids.
D) It is consistent with the activity of modern retroviruses that synthesize DNA.
E) It is inconsistent with the hypothesis that nucleic acids were the first catalysts.

A) It supports the hypothesis that proteins appeared on Earth before nucleic acids.
B) It would be impossible in reality, since RNA is synthesized from DNA.
C) It would require prebiotic synthesis of fatty acids.
D) It is consistent with the activity of modern retroviruses that synthesize DNA.
E) It is inconsistent with the hypothesis that nucleic acids were the first catalysts.
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62
Suppose that scientists succeed in creating experimental conditions that generate living cells from nonliving matter.Which statement best expresses how this achievement will affect thinking about the history of life on Earth?
A) The results will prove that life arose on Earth in a similar way, because it is so difficult to find just the right conditions to recreate the process in a lab.
B) The results will demonstrate that life could have arisen on Earth in a similar way, because we may never know what actual conditions were present on primitive Earth.
C) The results will suggest that life probably arose on Earth in a similar way, because scientists finally succeeded in reproducing the process in a lab.
D) The results will indicate that life could not have arisen on Earth in a similar way, because experiments in labs can never recreate exact conditions in the real world.
E) The results will indicate that life could not have arisen on Earth in a similar way, because there are too many variables and unknowns that make it impossible to test them all.
A) The results will prove that life arose on Earth in a similar way, because it is so difficult to find just the right conditions to recreate the process in a lab.
B) The results will demonstrate that life could have arisen on Earth in a similar way, because we may never know what actual conditions were present on primitive Earth.
C) The results will suggest that life probably arose on Earth in a similar way, because scientists finally succeeded in reproducing the process in a lab.
D) The results will indicate that life could not have arisen on Earth in a similar way, because experiments in labs can never recreate exact conditions in the real world.
E) The results will indicate that life could not have arisen on Earth in a similar way, because there are too many variables and unknowns that make it impossible to test them all.
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63
Refer to the figure below showing the Miller‒Urey experiment.
Research conducted later than the Miller‒Urey experiment showed that volcanic activity 4 billion years ago injected other gases, such as SO2, into Earth's early environment.This information led to the conclusion that
A) the original Miller-Urey experiment did not produce meaningful data.
B) a modified experiment should be performed in which other gases would be added to the initial heated solution.
C) the experiment required a longer running time to see whether the other gases would be produced.
D) the beaker of condensed liquid and compounds should be heated in the presence of the additional gases.
E) the Miller‒Urey experiment did not require modification, since cellular life existed earlier than 4 billion years ago.

A) the original Miller-Urey experiment did not produce meaningful data.
B) a modified experiment should be performed in which other gases would be added to the initial heated solution.
C) the experiment required a longer running time to see whether the other gases would be produced.
D) the beaker of condensed liquid and compounds should be heated in the presence of the additional gases.
E) the Miller‒Urey experiment did not require modification, since cellular life existed earlier than 4 billion years ago.
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64
Refer to the figure below showing a simplified time line of the origin of life.
Which event could have occurred before the evolution of RNA?
A) Formation of DNA
B) Evolution of cells
C) Prebiotic synthesis of amino acids
D) Development of ribozymes
E) Rise of protocells

A) Formation of DNA
B) Evolution of cells
C) Prebiotic synthesis of amino acids
D) Development of ribozymes
E) Rise of protocells
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65
Which was absent in the products analyzed at the conclusion of the Miller-Urey experiments?
A) Most of the amino acids used in protein synthesis
B) Small carbon sugars
C) Adenine and thymine
D) Nucleotides
E) Uracil
A) Most of the amino acids used in protein synthesis
B) Small carbon sugars
C) Adenine and thymine
D) Nucleotides
E) Uracil
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66
RNA molecules that act as catalysts are called
A) ribozymes.
B) glycosidic linkages.
C) chaperonins.
D) disulfide bridges.
E) triglycerides.
A) ribozymes.
B) glycosidic linkages.
C) chaperonins.
D) disulfide bridges.
E) triglycerides.
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67
Retroviruses, such as HIV, have an enzyme that allows them to catalyze DNA synthesis from an RNA template.This evidence supports the hypothesis that
A) RNA itself cannot be a catalyst.
B) early life consisted of an "RNA world."
C) RNA probably came from an extraterrestrial source.
D) chemical evolution led to polymerization.
E) DNA polymers form from RNA monomers.
A) RNA itself cannot be a catalyst.
B) early life consisted of an "RNA world."
C) RNA probably came from an extraterrestrial source.
D) chemical evolution led to polymerization.
E) DNA polymers form from RNA monomers.
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68
Refer to the figure below showing the Miller‒Urey experiment.
The experiment, which was performed in the 1950s,
A) showed that Earth's early environment had an atmosphere of N2, NH3, CH4, H2O, and H2.
B) showed that Earth's early atmosphere consisted of a combination of gases that is different from the one that exists today.
C) proved that carbon dioxide was present in Earth's early atmosphere.
D) demonstrated prebiotic synthesis of small molecules of life.
E) led to no meaningful conclusions, because there was no lightning in Earth's early environment.

A) showed that Earth's early environment had an atmosphere of N2, NH3, CH4, H2O, and H2.
B) showed that Earth's early atmosphere consisted of a combination of gases that is different from the one that exists today.
C) proved that carbon dioxide was present in Earth's early atmosphere.
D) demonstrated prebiotic synthesis of small molecules of life.
E) led to no meaningful conclusions, because there was no lightning in Earth's early environment.
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69
Which was a limitation of the Miller-Urey experiments in the 1950s?
A) The experiments synthesized both d- and l-isomers of amino acids, but the amino acids in living things are always l-isomers.
B) The experimenters made assumptions about Earth's early atmosphere that were later found to be inaccurate.
C) DNA is not self-catalytic.
D) In living organisms today, peptide linkages are catalyzed by ribozymes.
E) The hot temperatures of the experiments denatured some of the proteins that were synthesized.
A) The experiments synthesized both d- and l-isomers of amino acids, but the amino acids in living things are always l-isomers.
B) The experimenters made assumptions about Earth's early atmosphere that were later found to be inaccurate.
C) DNA is not self-catalytic.
D) In living organisms today, peptide linkages are catalyzed by ribozymes.
E) The hot temperatures of the experiments denatured some of the proteins that were synthesized.
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70
Which of these substances, present in the prebiotic environment on Earth, could have been critical in making the chemical synthesis of biologically important polymers more favorable?
A) Water
B) Sodium ions
C) Methane
D) Nickel ions
E) Hydrogen
A) Water
B) Sodium ions
C) Methane
D) Nickel ions
E) Hydrogen
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71
Which is evidence that supports the hypothesis that DNA could have evolved from RNA?
A) The discovery that retroviruses have an enzyme that catalyzes DNA synthesis from RNA
B) Evidence of the early emergence on Earth of chemical reactions that resulted in monomers
C) Evidence of the nearly spontaneous formation of lipid micelles on Earth
D) Evidence of the prebiotic chemical generation of cell-like compartments
E) The chemical traces of life found on meteorites
A) The discovery that retroviruses have an enzyme that catalyzes DNA synthesis from RNA
B) Evidence of the early emergence on Earth of chemical reactions that resulted in monomers
C) Evidence of the nearly spontaneous formation of lipid micelles on Earth
D) Evidence of the prebiotic chemical generation of cell-like compartments
E) The chemical traces of life found on meteorites
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72
Which statement is supported by the discovery that RNA can function as a catalyst?
A) Proteins were the first catalysts.
B) An "RNA world" of early life preceded the existence of DNA.
C) Prebiotic synthesis of the four bases of RNA is not necessary for life.
D) The prebiotic origin of small molecules was in ice on cold moons.
E) The prebiotic origin of small molecules occurred around hydrothermal vents.
A) Proteins were the first catalysts.
B) An "RNA world" of early life preceded the existence of DNA.
C) Prebiotic synthesis of the four bases of RNA is not necessary for life.
D) The prebiotic origin of small molecules was in ice on cold moons.
E) The prebiotic origin of small molecules occurred around hydrothermal vents.
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73
The "RNA world" hypothesis is supported by evidence that
A) RNA molecules spontaneously form spheres in water.
B) RNA can act as both genetic material and a catalyst.
C) amino acids can form RNA in particular chemical environments.
D) RNA can act as genetic material but not as a catalyst.
E) RNA monomers can form proteins.
A) RNA molecules spontaneously form spheres in water.
B) RNA can act as both genetic material and a catalyst.
C) amino acids can form RNA in particular chemical environments.
D) RNA can act as genetic material but not as a catalyst.
E) RNA monomers can form proteins.
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74
Hot water containing iron and nickel emerges from below Earth's crust at deep ocean hydrothermal vents where there is no oxygen.These metals catalyze the polymerization of amino acids in the absence of oxygen.This evidence supports the hypothesis of
A) the prebiotic synthesis of large molecules in Earth's early environment.
B) photosynthesis by cyanobacteria 3.5 billion years ago.
C) the prebiotic synthesis of small molecules in the ice of Europa, a moon of Jupiter.
D) the evolution of whales.
E) an extraterrestrial origin of life.
A) the prebiotic synthesis of large molecules in Earth's early environment.
B) photosynthesis by cyanobacteria 3.5 billion years ago.
C) the prebiotic synthesis of small molecules in the ice of Europa, a moon of Jupiter.
D) the evolution of whales.
E) an extraterrestrial origin of life.
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75
Chemical reaction rates vary depending on the concentrations of reactants.In which primitive Earth environment would conditions have shifted reactant concentrations to favor increased polymerization of monomers?
A) Rocky outcroppings with full sun exposure
B) Deep, wide freshwater lakes
C) Hot, sandy beaches
D) Shallow ponds with clay bottoms
E) Thermal vents deep in a salty ocean
A) Rocky outcroppings with full sun exposure
B) Deep, wide freshwater lakes
C) Hot, sandy beaches
D) Shallow ponds with clay bottoms
E) Thermal vents deep in a salty ocean
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76
Whether the process is abiotic or occurs in an organism, the synthesis of macromolecules
A) occurs with an increase of entropy.
B) is spontaneous.
C) requires energy.
D) results in a more random system.
E) gives off heat.
A) occurs with an increase of entropy.
B) is spontaneous.
C) requires energy.
D) results in a more random system.
E) gives off heat.
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77
Which may have facilitated the polymerization of the large molecules of life on primitive Earth?
A) Ice crystals
B) Evaporation in hot pools at the edges of oceans
C) Ribozymes
D) Early proteins
E) Lightning strikes in an anaerobic environment of methane, ammonia, hydrogen, and water vapor.
A) Ice crystals
B) Evaporation in hot pools at the edges of oceans
C) Ribozymes
D) Early proteins
E) Lightning strikes in an anaerobic environment of methane, ammonia, hydrogen, and water vapor.
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78
What evidence supports the possibility that life may have come from outside of Earth?
A) Amino acids in a meteorite were found to be a mixture of l- and d-isomers.
B) DNA molecules have been found in meteorites.
C) Other bodies in the solar system have, or once had, oxygen.
D) Other bodies in the solar system have, or once had, long-chain polypeptide molecules.
E) Other bodies in the solar system have gaseous atmospheres.
A) Amino acids in a meteorite were found to be a mixture of l- and d-isomers.
B) DNA molecules have been found in meteorites.
C) Other bodies in the solar system have, or once had, oxygen.
D) Other bodies in the solar system have, or once had, long-chain polypeptide molecules.
E) Other bodies in the solar system have gaseous atmospheres.
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79
In 1969, scientists shaved off pieces of the Murchison meteorite and found both D- and L-isomers of ten amino acids.Only L-isomers of amino acids are made by living organisms on Earth.This indicates that
A) Earth's amino acids could not have had an extraterrestrial origin.
B) the meteorite's amino acids as a whole could not have resulted from contamination by Earth organisms.
C) basic chemical building blocks of life have only formed on Earth.
D) life must have originated somewhere other than Earth.
E) life arose in many places besides Earth.
A) Earth's amino acids could not have had an extraterrestrial origin.
B) the meteorite's amino acids as a whole could not have resulted from contamination by Earth organisms.
C) basic chemical building blocks of life have only formed on Earth.
D) life must have originated somewhere other than Earth.
E) life arose in many places besides Earth.
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80
The Miller-Urey experiments demonstrated that
A) under specific conditions, the basic building blocks of life can form.
B) life on Earth came from other bodies in the solar system.
C) CO2, N2, H2S, and SO2 were probably present in Earth's early atmosphere.
D) volcanic eruptions may have released CO2, N2, H2S, and SO2 into Earth's early atmosphere.
E) ice is present in meteorites and on Mars.
A) under specific conditions, the basic building blocks of life can form.
B) life on Earth came from other bodies in the solar system.
C) CO2, N2, H2S, and SO2 were probably present in Earth's early atmosphere.
D) volcanic eruptions may have released CO2, N2, H2S, and SO2 into Earth's early atmosphere.
E) ice is present in meteorites and on Mars.
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