Deck 15: Antipsychotic Drugs

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Question
In schizophrenia,functional outcomes…

A) are a patient's willingness to take antipsychotic medications.
B) consist of a patient's ability to separate reality from fantasy.
C) include a patient's self-reported number of hallucinations or other psychotic behaviors.
D) consist of the capabilities a patient has to perform normal everyday activities.
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Question
Approximately what percentage of people have schizophrenia?

A) 1%
B) 5%
C) 10%
D) 15%
Question
A theory that attempts to link abnormalities in processing,coordinating,and responding to information to deficits in cognitive functioning is called…

A) sensory gating hypothesis.
B) dopamine hypothesis.
C) cognitive dysmetria.
D) schizophrenia prodrome hypothesis.
Question
If a patient with catatonic schizophrenia does not improve with antipsychotic medication,a psychiatrist may next prescribe a(n)…

A) psychostimulant drug.
B) benzodiazepine drug.
C) antidepressant drug.
D) opioid drug.
Question
All of the following are examples of functional outcomes in schizophrenia except…

A) making sense of a checking account.
B) carrying out daily hygeinic practices.
C) picking out appropriate clothing to wear.
D) having fewer depressive thoughts.
Question
There are profound and consistent impairments in cognitive functioning found in schizophrenia,but…

A) the DSM-5 does not consider this a symptom of schizophrenia.
B) this has no impact on functional outcomes.
C) this has no impact on a patient's quality of life.
D) medications are seldom used to address these impairments.
Question
For a patient with schizophrenia who appears socially withdrawn and displays litte emotion,a psychiatrist would likely note…

A) an indication of positive symptoms.
B) clear cognitive impairment.
C) the presense of negative symptoms.
D) disturbed thinking.
Question
For AIDS,antipsychotic drugs may be used to…

A) treat psychosis.
B) reduce muscle spasms.
C) counteract the side effects of other medications used for AIDS.
D) preclude the use of drugs of abuse.
Question
In schizophrenia,the addition of abnormal behaviors such as hallucinations are considered…

A) psychiatric symptoms.
B) behavioral symptoms.
C) negative symptoms.
D) positive symptom
Question
A reduction in normal behaviors,such as reduced emotional responsiveness,is called…

A) cognitive impairment.
B) positive symptoms.
C) negative symptoms.
D) disturbed thinking.
Question
Catatonia will occur in some patients with the following disorders except…

A) depression.
B) anxiety disorders.
C) alcohol withdrawal.
D) AIDS.
Question
The features of schizophrenia include all of the following except…

A) lifelong mental illness.
B) exceptional memory.
C) disturbed thinking.
D) an inability to understand what is real.
Question
Cognitive impairment in schizophrenia consists of…

A) deficits in working memory.
B) impaired attention.
C) reduced reference memory.
D) all of these.
Question
A patient with schizophrenia is normally first diagnosed around age…

A) 10.
B) 20.
C) 30.
D) 40.
Question
How many patients with schizophrenia treated with antipsychotics are able to find employment?

A) none.
B) some.
C) most.
D) all.
Question
The abandonment of schizophrenia subtypes from the DSM-5,although found in the earlier DSM-IV-TR,means…

A) that insurance companies were inconsistent with their coverage of each subtype.
B) that earlier editions of the DSM were incorrect about having different subtypes of schizophrenia.
C) the subtypes no longer exist in schizophrenia.
D) that the different subtypes did not add value to actually making a schizophrenia diagnosis.
Question
A patient who displays mostly positive symptoms including suspiciousness would likely be identified as having…

A) residual schizophrenia.
B) catatonic schizophrenia.
C) disorganized schizophrenia.
D) paranoid schizophrenia.
Question
An inability to ignore unimportant stimuli from one's environment is referred to as a(n)…

A) jump to conclusions.
B) inattention to detail.
C) sensory-gating deficit.
D) memory impairment.
Question
A patient with schizophrenia who has not improved after two attempts of treatment with an antipsycotic drug would be identified as…

A) a poor antipsychotic metabolizer.
B) having treatment-resistant schizophrenia.
C) a patient with poor compliance.
D) having residual schizophrenia.
Question
A patient who displays significant negative symptoms including little body movement would likely be identified as having…

A) catatonic schizophrenia.
B) disorganized schizophrenia.
C) paranoid schizophrenia.
D) undifferentiated schizophrenia.
Question
In 1871,Ewald Hecker coined a mental disorder ___________,which later became known as schizophrenia.

A) hebephrenia
B) dementia praecox
C) nervous breakdown
D) cognitive dysmetria
Question
The DISC1 protein…

A) plays a role in neuron development.
B) is a precusor for the synthesis of dopamine.
C) specifically grows neurons in the ventral tegmental area.
D) is found concentrated in the hippocampus.
Question
The result of a frontal lobotomy was typically…

A) an inability to recall long-term memories.
B) a complete recovery from symptoms of schizophrenia.
C) drowsiness and disorientation.
D) highly aggressive behavior.
Question
All of the following were attempted treatments for schizophrenia that eventually ceased after the discovery of antipsychotic drugs except…

A) ice baths.
B) electrical shocks.
C) frontal lobotomies.
D) isolation cells.
Question
For someone exhibiting prodromal features of schizophrenia,schizophrenia may develop from…

A) factors such as stress.
B) a genetic trigger at a certain stage of development.
C) a physical injury.
D) reading fantasy novels.
Question
Dr.Walter Freeman became best known for…

A) standard lobotomy.
B) transcranial lobotomy.
C) open lobotomy.
D) transorbital leucotomy.
Question
A hypothesis of schizophrenia that states that abnormal nervous system development leads to changes in the brain that cause schizophrenia is called the…

A) neurodegenerative hypothesis.
B) dopamine hypothesis.
C) prodromal hypothesis.
D) neurodevelopmental hypothesis.
Question
Prior to a first diagnosis of schizophrenia,early signs of schizophrenia likely occur before this during the…

A) prodromal phase of schizophrenia.
B) pre-schizophrenia phase.
C) early development phase of schizophrenia.
D) pre-cognitive phase of schizophrenia.
Question
Chlorprozamine was developed as a(n)…

A) antipsychotic drug.
B) antidepressant drugs.
C) preanesthetic drug.
D) analgesic drug.
Question
While clear changes in the size of neural tissue has alluded schizophrenia researchers…

A) the size of the ventral tegmental is modestly, but consistently, larger in schizophrenia.
B) the size of neurons appears to be smaller in schizophrenia.
C) ventricles are large in schizophrenia patients.
D) neural networks may be abnormal in schizophrenia patients.
Question
Bleuler used the term schizophrenia based on observing…

A) separation for reality.
B) splitting of psychic functions.
C) engagement in childlike thinking.
D) dementia symptoms occurring in young adults.
Question
Most evidence for a genetic basis of schizophrenia points to the…

A) Finnish schizophrenia gene.
B) disrupted schizophrenia 1 gene.
C) dopamine transporter gene.
D) serotonin transporter gene.
Question
An individual who has an immediate relative with schizophrenia and has recently begun having poor grades in school,declined short-term memory,and is having paranoid thinking is likely in the…

A) pre-cognitive dysmetric stage of schizophrenia.
B) prodromal phase of schizophrenia.
C) early development phase of schizophrenia.
D) dopamine hyperactivity phase of schizophrenia.
Question
For identical twins,if one of the twins has schizophrenia,what is the chance that the other twin will have schizophrenia?

A) 0%
B) 25%
C) 50%
D) 100%
Question
Those with schizophrenia appear to have fewer projections from the thalamus to the…

A) prefrontal cortex.
B) hippocampus.
C) cingulate cortex.
D) cerebellum.
Question
An investigation into how changes in fetal development might cause symptoms of schizophrenia in early adulthood would likely be following the …

A) neurodegenerative hypothesis.
B) dopamine hypothesis.
C) prodromal hypothesis.
D) neurodevelopmental hypothesis.
Question
Kraeplin used the term __________ for schizophrenia after noting certain changes in memory and thinking that he saw in elderly patients.

A) split personality
B) hebephrenia praecox
C) dementia praecox
D) early-onset Alzheimer's disease
Question
The reason why an identical twin does not while her other twin does have schizophrenia is likely due to…

A) the length of time of engaging in imaginary play as children.
B) a willingness not to engage in paranoid thoughts.
C) one's medication history.
D) differences in how genes are expressed.
Question
The first antipyschotic drug that was discovered was …

A) chlorpromazine.
B) chlordiazepoxide.
C) clozapine.
D) haloperidol.
Question
The most consistent structural difference for those with schizophrenia includes…

A) reduced volume in the right prefrontal cortex.
B) reduced volume of the left temporal lobe.
C) increased volume of the left and right hippocampus.
D) reduced volume of the right nucleus accumbens.
Question
Based on the glutamate hypothesis of schizophrenia,an agonist for glutamate might…

A) have no effects.
B) reduce the symptoms of schizophrenia.
C) worsen the symptoms of schizophrenia.
D) diminish the effectiveness of antipsychotic drugs.
Question
Unlike the dopamine hypothesis,the glutamate hypothesis for schizophrenia…

A) explains a lack of treatment response in some patients.
B) accounts for positive symptoms.
C) accounts for cognitive dysfunction.
D) explains drug withdrawal from antipsychotic medications.
Question
The two neurotransmitters most implicated in the symptoms of schizophrenia are…

A) serotonin and GABA.
B) GABA and glutamate.
C) dopamine and serotonin.
D) dopamine and glutamate.
Question
A drug that reduced the firing rate of mesolimbic dopamine neurons for a patient with schizophrenia would likely…

A) reduce positive symptoms.
B) have no effects.
C) worsen symptoms.
D) counteract the effects of antipsychotic drugs.
Question
The effective clinical dose of an antipsychotic drug…

A) correlates with its binding affinity for NMDA receptors.
B) is not related to any known neurological actions.
C) is typically as effective as placebo.
D) correlates with its binding affinity for D₂ receptors.
Question
How do extrapyramidal side effects occur from antipsychotic medications if dopamine neurons are overactivated in schizophrenia?

A) After antipsychotics bind to D₂ receptors in the limbic system, most drug molecules are left for blocking receptors in the basal ganglia.
B) Antipsychotics have a stronger affinity for dopamine receptors in the basal ganglia.
C) Mesolimbic neurons are overactivated in schizophrenia, but nigrostriatal neurons are not.
D) Inhibition of glutamate neurons in turn causes an inhibition of nigrostriatal neurons.
Question
A Nobel Prize was not awarded for the discovery of the antipsychotic effects of chlorpromazine and the subsequent spark in psychopharmacology as a field likely due to…

A) not having substantial impact on medicine.
B) the fact that other antipsychotic drugs were already in development.
C) heated disagreements about who was responsible for making the discovery.
D) a failure to treat schizophrenia in all patients.
Question
Haloperidol is a(n)…

A) atypical antipsychotic drug.
B) typical antipsychotic drug.
C) novel antipsychotic drug.
D) second-generation antipsychotic drug.
Question
Tremor,muscle rigidity,and involuntary movements caused by antipsychotic drugs are called…

A) Parkinson's disease.
B) extrapyramidal side effects.
C) motor inhibition syndrome.
D) negative symptoms.
Question
Inferred from the dopamine hypothesis and the actions of antipsychotic drugs,activation of ________ receptors likely leads to antipsychotic symptoms.

A) 5-HT₂A
B) D₂
C) NMDA
D) GABAA
Question
The primary mechanism of action for a typical antipsychotic drug is…

A) agonism of D₂ receptors.
B) antagonism of D₂ receptors.
C) antagonism of NMDA receptors.
D) antagonism for 5-HT₂A receptors.
Question
The hypothesis stating that positive symptoms arise from excessive dopamine release in the limbic system is called the…

A) dopamine hypothesis.
B) hypofrontal hypothesis.
C) glutamate hypothesis.
D) serotonin-dopamine hypothesis.
Question
Chlorpromazine is a(n)…

A) typical antipsychotic drug.
B) second-generation antipsychotic drug.
C) atypical antipsychotic drug.
D) novel antipsychotic drug.
Question
The first antipsychotic drugs,including chlorpromazine and haloperidol,are known by all of the following except…

A) first-generation antipsychotics.
B) classical antipsychotics
C) neuroleptics.
D) early antipsychotics.
Question
Giving a substantial dose of a dissociative anesthetic drug phencyclidine to a healthy human would exhibit…

A) schizophrenia-like effects if also treated with an antipsychtoic drug.
B) effects similar to the negative and positive symptoms of schizophrenia.
C) effects similar to the negative symptoms but not the positive symptoms of schizophrenia.
D) only cognitive impairment similar to that seen in schizophrenia.
Question
For the most part,antipsychotic drugs must at least serve as antagonists for the _______ receptor to reduce positive symptoms of schizophrenia.

A) NMDA
B) D₂
C) 5-HT₂A
D) GABAA
Question
The glutamate hypothesis for schizophrenia states the symtoms of schizophrenia derive from…

A) low levels of glutamate neurotransmission in the cerebral cortex.
B) overrelease of dopamine from mesocortical dopamine neurons.
C) excitoxicity in the limbic system.
D) overactivation of circuits connecting the thalamus to the cerebellum and prefrontal cortex.
Question
All of the following are found from typical antipsychotic drug treatment except…

A) effectivenss for negative symptoms.
B) effectiveness for positive symptoms.
C) risk of extrapyramidal side effects.
D) little efficacy for cognitive impairment.
Question
If a new drug were developed that was effective for the positive symptoms of schizophrenia but produce significant extrapyramidal side effects,then the drug is likely a(n)…

A) typical antipsychotic drug.
B) benzodiazepine drug.
C) atypical antipsychotic drug.
D) third-generation antipsychotic drug.
Question
If a substantial dose of a synthetic cathinone was given to a person without mental illness,what would likely happen?

A) An antipsychotic drug would enhance the effects of cathinone.
B) The person would become withdrawn, similar to negative symptoms in schizophrenia.
C) The person would have effects similar to positive symptoms in schizophrenia.
D) A person would permanently develop the features of schizophrenia.
Question
Severe flu-like symptoms associated with autonomic nervous regularities from taking antipsychotic medication are referred to as…

A) hyperprolactinemia.
B) neuroleptic withdrawal syndrome.
C) neuroleptic malignant syndrome.
D) emesis.
Question
The first recognized atypical antipsychotic drug was…

A) olanzapine.
B) risperidone.
C) thioridazine.
D) clozapine.
Question
Third-generation antipsychotic drugs generally act as…

A) D₂ fastoff drugs.
B) inverse antagonists for 5-HT₂A receptors.
C) partial D₂ receptor agonists.
D) partial agonists for 5-HT₂A receptors.
Question
The most utilized hypothesis for developing an atypical antipsychotic drug is…

A) agonism for NMDA receptors in addition to antagonism of D₂ receptors.
B) partial agonism of D₂ receptors.
C) a preferential affinity for 5-HT₂A receptors over D₂ receptors.
D) binding to GABAA receptors in addition to D₂ receptors.
Question
Antagonism of alpha2 adrenoceptors may…

A) increase depressive symptoms in schizophrenia.
B) contribute to atypical antipsychotic effects.
C) cause weight gain.
D) cause QT interval prolongation.
Question
Atypical antipsychotic drugs may achieve an improved efficacy for cognitive functioning by…

A) increasing dopamine levels in the nucleus accumbens.
B) increasing dopamine levels in the ventral tegmental area.
C) decreasing serotonin levels in the prefrontal cortex.
D) elevating dopamine levels in the prefrontal cortex.
Question
A motor disorder that affects muscles primarily around the mouth or other parts of face is called…

A) cardiovascular dementia.
B) tardive dyskinesia.
C) acute dystonia.
D) extrapyramidal dyskinesia.
Question
A hypothesis for how to develop an atypical antipsychotic drug states that an antagonist for D₂ receptors that quickly separates from the receptor is called the…

A) fast D₂-off hypothesis.
B) serotonin-dopamine hypothesis.
C) D₂ partial agonism hypothesis
D) D?₂ agonist-antagonist hypothesis
Question
Antagonism of 5-HT₂C receptors is associated with…

A) depressive symptoms in schizophrenia.
B) atypical antipsychotic effects.
C) weight gain.
D) QT interval prolongation.
Question
In order to prevent a patient from not taking an antipsychotic medication,all of the following administration forms can be used except…

A) a pill.
B) nasal spray.
C) intramuscular injection.
D) dissolvable pill for the tongue.
Question
Some atypical antipsychotic drugs produce a severe decline in white blood cell counts,referred to as…

A) neuroleptic malignant immune system disorder.
B) neuroleptic-associated immune syndrome.
C) QT interval prolongation.
D) agranulocytosis.
Question
An approved treatment for autism spectrum disorder is…

A) risperidone.
B) haloperidol.
C) clozapine.
D) chlorpromazine.
Question
While anticholinergic drugs reduce extrapyramidal side effects,they do not prevent the development of…

A) cardiovascular dementia.
B) tardive dyskinesia.
C) acute dystonia.
D) extrapyramidal dyskinesia.
Question
Many atypical antipsychotic drugs cause a prolongation of heartbeat,referred to as…

A) QT interval prolongation.
B) TP interval prolongation.
C) calcium channel inhibition.
D) neuroleptic-associated hypotension.
Question
Atypical antipsychotic drugs differ from typical antipsychotic drugs in all of the following ways except…

A) improved efficacy for positive symptoms.
B) reduced risk of extrapyramidal side effects.
C) improved efficacy for negative symptoms.
D) improvements in cognitive functioning.
Question
When a typical antipsychotic drug is prescribed,physicians commonly also prescribe…

A) a non-benzodiazepine hypnotic.
B) a benzodiazepine drug.
C) a psychostimulant drug.
D) an anticholinergic drug.
Question
The antimetic effects of antipsychotic drugs derive from…

A) interrupted signalling from the chemoreceptor trigger zone to the area postrema.
B) blockade of dopamine receptors in the mesolimbic dopamine pathway.
C) antagonism of dopamien receptors in the hypothalamus.
D) activating pathways from the amygdala to the chemoreceptor trigger zone.
Question
If a researcher develops a new compound that acts only as a D₂ receptor antagonist but does not produce extrapyramidal side effects in animals,the drug likely…

A) will be ineffective as an antipsychotic drug.
B) has an active metabolite that is an agonist for D₂ receptors.
C) has downstream effects that lead to the activation of 5-HT₂A receptors.
D) binds to the D₂ receptor but quickly separates from the receptor.
Question
Hyperprolactinemia occurs from…

A) agonism of D₁ receptors.
B) antagonism of D₂ receptors.
C) antagonism of 5-HT₂A receptors.
D) antagonism of NMDA receptors.
Question
In animals,if an experimental drug was shown to produce extrapyramidal side effects that subside as the drug's effects wear off,the researchers should conclude that the drug…

A) will reduce positive symptoms in schizophrenia.
B) will produce Parkinson's disease.
C) acts on the primary motor cortex.
D) will worsen the symptoms of schizophrenia.
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Deck 15: Antipsychotic Drugs
1
In schizophrenia,functional outcomes…

A) are a patient's willingness to take antipsychotic medications.
B) consist of a patient's ability to separate reality from fantasy.
C) include a patient's self-reported number of hallucinations or other psychotic behaviors.
D) consist of the capabilities a patient has to perform normal everyday activities.
D
2
Approximately what percentage of people have schizophrenia?

A) 1%
B) 5%
C) 10%
D) 15%
A
3
A theory that attempts to link abnormalities in processing,coordinating,and responding to information to deficits in cognitive functioning is called…

A) sensory gating hypothesis.
B) dopamine hypothesis.
C) cognitive dysmetria.
D) schizophrenia prodrome hypothesis.
C
4
If a patient with catatonic schizophrenia does not improve with antipsychotic medication,a psychiatrist may next prescribe a(n)…

A) psychostimulant drug.
B) benzodiazepine drug.
C) antidepressant drug.
D) opioid drug.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
5
All of the following are examples of functional outcomes in schizophrenia except…

A) making sense of a checking account.
B) carrying out daily hygeinic practices.
C) picking out appropriate clothing to wear.
D) having fewer depressive thoughts.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
6
There are profound and consistent impairments in cognitive functioning found in schizophrenia,but…

A) the DSM-5 does not consider this a symptom of schizophrenia.
B) this has no impact on functional outcomes.
C) this has no impact on a patient's quality of life.
D) medications are seldom used to address these impairments.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
7
For a patient with schizophrenia who appears socially withdrawn and displays litte emotion,a psychiatrist would likely note…

A) an indication of positive symptoms.
B) clear cognitive impairment.
C) the presense of negative symptoms.
D) disturbed thinking.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
8
For AIDS,antipsychotic drugs may be used to…

A) treat psychosis.
B) reduce muscle spasms.
C) counteract the side effects of other medications used for AIDS.
D) preclude the use of drugs of abuse.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
9
In schizophrenia,the addition of abnormal behaviors such as hallucinations are considered…

A) psychiatric symptoms.
B) behavioral symptoms.
C) negative symptoms.
D) positive symptom
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
10
A reduction in normal behaviors,such as reduced emotional responsiveness,is called…

A) cognitive impairment.
B) positive symptoms.
C) negative symptoms.
D) disturbed thinking.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
11
Catatonia will occur in some patients with the following disorders except…

A) depression.
B) anxiety disorders.
C) alcohol withdrawal.
D) AIDS.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
12
The features of schizophrenia include all of the following except…

A) lifelong mental illness.
B) exceptional memory.
C) disturbed thinking.
D) an inability to understand what is real.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
13
Cognitive impairment in schizophrenia consists of…

A) deficits in working memory.
B) impaired attention.
C) reduced reference memory.
D) all of these.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
14
A patient with schizophrenia is normally first diagnosed around age…

A) 10.
B) 20.
C) 30.
D) 40.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
15
How many patients with schizophrenia treated with antipsychotics are able to find employment?

A) none.
B) some.
C) most.
D) all.
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Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
16
The abandonment of schizophrenia subtypes from the DSM-5,although found in the earlier DSM-IV-TR,means…

A) that insurance companies were inconsistent with their coverage of each subtype.
B) that earlier editions of the DSM were incorrect about having different subtypes of schizophrenia.
C) the subtypes no longer exist in schizophrenia.
D) that the different subtypes did not add value to actually making a schizophrenia diagnosis.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
17
A patient who displays mostly positive symptoms including suspiciousness would likely be identified as having…

A) residual schizophrenia.
B) catatonic schizophrenia.
C) disorganized schizophrenia.
D) paranoid schizophrenia.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
18
An inability to ignore unimportant stimuli from one's environment is referred to as a(n)…

A) jump to conclusions.
B) inattention to detail.
C) sensory-gating deficit.
D) memory impairment.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
19
A patient with schizophrenia who has not improved after two attempts of treatment with an antipsycotic drug would be identified as…

A) a poor antipsychotic metabolizer.
B) having treatment-resistant schizophrenia.
C) a patient with poor compliance.
D) having residual schizophrenia.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
20
A patient who displays significant negative symptoms including little body movement would likely be identified as having…

A) catatonic schizophrenia.
B) disorganized schizophrenia.
C) paranoid schizophrenia.
D) undifferentiated schizophrenia.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
21
In 1871,Ewald Hecker coined a mental disorder ___________,which later became known as schizophrenia.

A) hebephrenia
B) dementia praecox
C) nervous breakdown
D) cognitive dysmetria
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
22
The DISC1 protein…

A) plays a role in neuron development.
B) is a precusor for the synthesis of dopamine.
C) specifically grows neurons in the ventral tegmental area.
D) is found concentrated in the hippocampus.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
23
The result of a frontal lobotomy was typically…

A) an inability to recall long-term memories.
B) a complete recovery from symptoms of schizophrenia.
C) drowsiness and disorientation.
D) highly aggressive behavior.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
24
All of the following were attempted treatments for schizophrenia that eventually ceased after the discovery of antipsychotic drugs except…

A) ice baths.
B) electrical shocks.
C) frontal lobotomies.
D) isolation cells.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
25
For someone exhibiting prodromal features of schizophrenia,schizophrenia may develop from…

A) factors such as stress.
B) a genetic trigger at a certain stage of development.
C) a physical injury.
D) reading fantasy novels.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
26
Dr.Walter Freeman became best known for…

A) standard lobotomy.
B) transcranial lobotomy.
C) open lobotomy.
D) transorbital leucotomy.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
27
A hypothesis of schizophrenia that states that abnormal nervous system development leads to changes in the brain that cause schizophrenia is called the…

A) neurodegenerative hypothesis.
B) dopamine hypothesis.
C) prodromal hypothesis.
D) neurodevelopmental hypothesis.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
28
Prior to a first diagnosis of schizophrenia,early signs of schizophrenia likely occur before this during the…

A) prodromal phase of schizophrenia.
B) pre-schizophrenia phase.
C) early development phase of schizophrenia.
D) pre-cognitive phase of schizophrenia.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
29
Chlorprozamine was developed as a(n)…

A) antipsychotic drug.
B) antidepressant drugs.
C) preanesthetic drug.
D) analgesic drug.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
30
While clear changes in the size of neural tissue has alluded schizophrenia researchers…

A) the size of the ventral tegmental is modestly, but consistently, larger in schizophrenia.
B) the size of neurons appears to be smaller in schizophrenia.
C) ventricles are large in schizophrenia patients.
D) neural networks may be abnormal in schizophrenia patients.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
31
Bleuler used the term schizophrenia based on observing…

A) separation for reality.
B) splitting of psychic functions.
C) engagement in childlike thinking.
D) dementia symptoms occurring in young adults.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
32
Most evidence for a genetic basis of schizophrenia points to the…

A) Finnish schizophrenia gene.
B) disrupted schizophrenia 1 gene.
C) dopamine transporter gene.
D) serotonin transporter gene.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
33
An individual who has an immediate relative with schizophrenia and has recently begun having poor grades in school,declined short-term memory,and is having paranoid thinking is likely in the…

A) pre-cognitive dysmetric stage of schizophrenia.
B) prodromal phase of schizophrenia.
C) early development phase of schizophrenia.
D) dopamine hyperactivity phase of schizophrenia.
Unlock Deck
Unlock for access to all 114 flashcards in this deck.
Unlock Deck
k this deck
34
For identical twins,if one of the twins has schizophrenia,what is the chance that the other twin will have schizophrenia?

A) 0%
B) 25%
C) 50%
D) 100%
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Unlock for access to all 114 flashcards in this deck.
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35
Those with schizophrenia appear to have fewer projections from the thalamus to the…

A) prefrontal cortex.
B) hippocampus.
C) cingulate cortex.
D) cerebellum.
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36
An investigation into how changes in fetal development might cause symptoms of schizophrenia in early adulthood would likely be following the …

A) neurodegenerative hypothesis.
B) dopamine hypothesis.
C) prodromal hypothesis.
D) neurodevelopmental hypothesis.
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37
Kraeplin used the term __________ for schizophrenia after noting certain changes in memory and thinking that he saw in elderly patients.

A) split personality
B) hebephrenia praecox
C) dementia praecox
D) early-onset Alzheimer's disease
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38
The reason why an identical twin does not while her other twin does have schizophrenia is likely due to…

A) the length of time of engaging in imaginary play as children.
B) a willingness not to engage in paranoid thoughts.
C) one's medication history.
D) differences in how genes are expressed.
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39
The first antipyschotic drug that was discovered was …

A) chlorpromazine.
B) chlordiazepoxide.
C) clozapine.
D) haloperidol.
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40
The most consistent structural difference for those with schizophrenia includes…

A) reduced volume in the right prefrontal cortex.
B) reduced volume of the left temporal lobe.
C) increased volume of the left and right hippocampus.
D) reduced volume of the right nucleus accumbens.
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41
Based on the glutamate hypothesis of schizophrenia,an agonist for glutamate might…

A) have no effects.
B) reduce the symptoms of schizophrenia.
C) worsen the symptoms of schizophrenia.
D) diminish the effectiveness of antipsychotic drugs.
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42
Unlike the dopamine hypothesis,the glutamate hypothesis for schizophrenia…

A) explains a lack of treatment response in some patients.
B) accounts for positive symptoms.
C) accounts for cognitive dysfunction.
D) explains drug withdrawal from antipsychotic medications.
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43
The two neurotransmitters most implicated in the symptoms of schizophrenia are…

A) serotonin and GABA.
B) GABA and glutamate.
C) dopamine and serotonin.
D) dopamine and glutamate.
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44
A drug that reduced the firing rate of mesolimbic dopamine neurons for a patient with schizophrenia would likely…

A) reduce positive symptoms.
B) have no effects.
C) worsen symptoms.
D) counteract the effects of antipsychotic drugs.
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45
The effective clinical dose of an antipsychotic drug…

A) correlates with its binding affinity for NMDA receptors.
B) is not related to any known neurological actions.
C) is typically as effective as placebo.
D) correlates with its binding affinity for D₂ receptors.
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46
How do extrapyramidal side effects occur from antipsychotic medications if dopamine neurons are overactivated in schizophrenia?

A) After antipsychotics bind to D₂ receptors in the limbic system, most drug molecules are left for blocking receptors in the basal ganglia.
B) Antipsychotics have a stronger affinity for dopamine receptors in the basal ganglia.
C) Mesolimbic neurons are overactivated in schizophrenia, but nigrostriatal neurons are not.
D) Inhibition of glutamate neurons in turn causes an inhibition of nigrostriatal neurons.
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47
A Nobel Prize was not awarded for the discovery of the antipsychotic effects of chlorpromazine and the subsequent spark in psychopharmacology as a field likely due to…

A) not having substantial impact on medicine.
B) the fact that other antipsychotic drugs were already in development.
C) heated disagreements about who was responsible for making the discovery.
D) a failure to treat schizophrenia in all patients.
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48
Haloperidol is a(n)…

A) atypical antipsychotic drug.
B) typical antipsychotic drug.
C) novel antipsychotic drug.
D) second-generation antipsychotic drug.
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49
Tremor,muscle rigidity,and involuntary movements caused by antipsychotic drugs are called…

A) Parkinson's disease.
B) extrapyramidal side effects.
C) motor inhibition syndrome.
D) negative symptoms.
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50
Inferred from the dopamine hypothesis and the actions of antipsychotic drugs,activation of ________ receptors likely leads to antipsychotic symptoms.

A) 5-HT₂A
B) D₂
C) NMDA
D) GABAA
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51
The primary mechanism of action for a typical antipsychotic drug is…

A) agonism of D₂ receptors.
B) antagonism of D₂ receptors.
C) antagonism of NMDA receptors.
D) antagonism for 5-HT₂A receptors.
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52
The hypothesis stating that positive symptoms arise from excessive dopamine release in the limbic system is called the…

A) dopamine hypothesis.
B) hypofrontal hypothesis.
C) glutamate hypothesis.
D) serotonin-dopamine hypothesis.
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53
Chlorpromazine is a(n)…

A) typical antipsychotic drug.
B) second-generation antipsychotic drug.
C) atypical antipsychotic drug.
D) novel antipsychotic drug.
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54
The first antipsychotic drugs,including chlorpromazine and haloperidol,are known by all of the following except…

A) first-generation antipsychotics.
B) classical antipsychotics
C) neuroleptics.
D) early antipsychotics.
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55
Giving a substantial dose of a dissociative anesthetic drug phencyclidine to a healthy human would exhibit…

A) schizophrenia-like effects if also treated with an antipsychtoic drug.
B) effects similar to the negative and positive symptoms of schizophrenia.
C) effects similar to the negative symptoms but not the positive symptoms of schizophrenia.
D) only cognitive impairment similar to that seen in schizophrenia.
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56
For the most part,antipsychotic drugs must at least serve as antagonists for the _______ receptor to reduce positive symptoms of schizophrenia.

A) NMDA
B) D₂
C) 5-HT₂A
D) GABAA
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57
The glutamate hypothesis for schizophrenia states the symtoms of schizophrenia derive from…

A) low levels of glutamate neurotransmission in the cerebral cortex.
B) overrelease of dopamine from mesocortical dopamine neurons.
C) excitoxicity in the limbic system.
D) overactivation of circuits connecting the thalamus to the cerebellum and prefrontal cortex.
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58
All of the following are found from typical antipsychotic drug treatment except…

A) effectivenss for negative symptoms.
B) effectiveness for positive symptoms.
C) risk of extrapyramidal side effects.
D) little efficacy for cognitive impairment.
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59
If a new drug were developed that was effective for the positive symptoms of schizophrenia but produce significant extrapyramidal side effects,then the drug is likely a(n)…

A) typical antipsychotic drug.
B) benzodiazepine drug.
C) atypical antipsychotic drug.
D) third-generation antipsychotic drug.
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60
If a substantial dose of a synthetic cathinone was given to a person without mental illness,what would likely happen?

A) An antipsychotic drug would enhance the effects of cathinone.
B) The person would become withdrawn, similar to negative symptoms in schizophrenia.
C) The person would have effects similar to positive symptoms in schizophrenia.
D) A person would permanently develop the features of schizophrenia.
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61
Severe flu-like symptoms associated with autonomic nervous regularities from taking antipsychotic medication are referred to as…

A) hyperprolactinemia.
B) neuroleptic withdrawal syndrome.
C) neuroleptic malignant syndrome.
D) emesis.
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62
The first recognized atypical antipsychotic drug was…

A) olanzapine.
B) risperidone.
C) thioridazine.
D) clozapine.
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63
Third-generation antipsychotic drugs generally act as…

A) D₂ fastoff drugs.
B) inverse antagonists for 5-HT₂A receptors.
C) partial D₂ receptor agonists.
D) partial agonists for 5-HT₂A receptors.
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64
The most utilized hypothesis for developing an atypical antipsychotic drug is…

A) agonism for NMDA receptors in addition to antagonism of D₂ receptors.
B) partial agonism of D₂ receptors.
C) a preferential affinity for 5-HT₂A receptors over D₂ receptors.
D) binding to GABAA receptors in addition to D₂ receptors.
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65
Antagonism of alpha2 adrenoceptors may…

A) increase depressive symptoms in schizophrenia.
B) contribute to atypical antipsychotic effects.
C) cause weight gain.
D) cause QT interval prolongation.
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66
Atypical antipsychotic drugs may achieve an improved efficacy for cognitive functioning by…

A) increasing dopamine levels in the nucleus accumbens.
B) increasing dopamine levels in the ventral tegmental area.
C) decreasing serotonin levels in the prefrontal cortex.
D) elevating dopamine levels in the prefrontal cortex.
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67
A motor disorder that affects muscles primarily around the mouth or other parts of face is called…

A) cardiovascular dementia.
B) tardive dyskinesia.
C) acute dystonia.
D) extrapyramidal dyskinesia.
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68
A hypothesis for how to develop an atypical antipsychotic drug states that an antagonist for D₂ receptors that quickly separates from the receptor is called the…

A) fast D₂-off hypothesis.
B) serotonin-dopamine hypothesis.
C) D₂ partial agonism hypothesis
D) D?₂ agonist-antagonist hypothesis
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69
Antagonism of 5-HT₂C receptors is associated with…

A) depressive symptoms in schizophrenia.
B) atypical antipsychotic effects.
C) weight gain.
D) QT interval prolongation.
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70
In order to prevent a patient from not taking an antipsychotic medication,all of the following administration forms can be used except…

A) a pill.
B) nasal spray.
C) intramuscular injection.
D) dissolvable pill for the tongue.
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71
Some atypical antipsychotic drugs produce a severe decline in white blood cell counts,referred to as…

A) neuroleptic malignant immune system disorder.
B) neuroleptic-associated immune syndrome.
C) QT interval prolongation.
D) agranulocytosis.
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72
An approved treatment for autism spectrum disorder is…

A) risperidone.
B) haloperidol.
C) clozapine.
D) chlorpromazine.
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73
While anticholinergic drugs reduce extrapyramidal side effects,they do not prevent the development of…

A) cardiovascular dementia.
B) tardive dyskinesia.
C) acute dystonia.
D) extrapyramidal dyskinesia.
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74
Many atypical antipsychotic drugs cause a prolongation of heartbeat,referred to as…

A) QT interval prolongation.
B) TP interval prolongation.
C) calcium channel inhibition.
D) neuroleptic-associated hypotension.
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75
Atypical antipsychotic drugs differ from typical antipsychotic drugs in all of the following ways except…

A) improved efficacy for positive symptoms.
B) reduced risk of extrapyramidal side effects.
C) improved efficacy for negative symptoms.
D) improvements in cognitive functioning.
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76
When a typical antipsychotic drug is prescribed,physicians commonly also prescribe…

A) a non-benzodiazepine hypnotic.
B) a benzodiazepine drug.
C) a psychostimulant drug.
D) an anticholinergic drug.
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77
The antimetic effects of antipsychotic drugs derive from…

A) interrupted signalling from the chemoreceptor trigger zone to the area postrema.
B) blockade of dopamine receptors in the mesolimbic dopamine pathway.
C) antagonism of dopamien receptors in the hypothalamus.
D) activating pathways from the amygdala to the chemoreceptor trigger zone.
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78
If a researcher develops a new compound that acts only as a D₂ receptor antagonist but does not produce extrapyramidal side effects in animals,the drug likely…

A) will be ineffective as an antipsychotic drug.
B) has an active metabolite that is an agonist for D₂ receptors.
C) has downstream effects that lead to the activation of 5-HT₂A receptors.
D) binds to the D₂ receptor but quickly separates from the receptor.
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79
Hyperprolactinemia occurs from…

A) agonism of D₁ receptors.
B) antagonism of D₂ receptors.
C) antagonism of 5-HT₂A receptors.
D) antagonism of NMDA receptors.
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k this deck
80
In animals,if an experimental drug was shown to produce extrapyramidal side effects that subside as the drug's effects wear off,the researchers should conclude that the drug…

A) will reduce positive symptoms in schizophrenia.
B) will produce Parkinson's disease.
C) acts on the primary motor cortex.
D) will worsen the symptoms of schizophrenia.
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Unlock Deck
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