Deck 22: Bone and Soft Tissues

Question 1

A 70 year old man complained of headache to his GP.He thought something was seriously wrong,because he had noticed his hat size was also increasing,and he feared underlying bone cancer.A biopsy of his skull was performed,and is compared with normal bone on the left.Both sections are undecalcified,and are stained with Goldner's trichrome,which stains uncalcified osteoid (Ost)pink,and calcified matrix green.Which one of the following diagnoses is most likely correct?

A)Osteogenic sarcoma
B)Osteoporosis
C)Osteomalacia
D)Osteomyelitis
E)Paget's disease of bone

Answer 1

Paget's disease of bone

Question 2

A 69 year old man was seen by his GP for pain in the right hip.An x-ray revealed a large mass involving the pelvis that was pressing on the joint.A biopsy was performed,and a representative section is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

A)Chondrosarcoma
B)Fracture,with non-union
C)Osteogenic sarcoma
D)Osteoid osteoma
E)Paget's disease of bone

Answer 2

Chondrosarcoma

Question 3

A 15 year old boy was kicked in the leg during a football game.The coach put ice on it,and he seemed ok,but three weeks later,he still had pain above his knee that kept him awake at night.An x-ray revealed a large mass in the femur.A biopsy was performed,a representative section of which is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

A)Chondrosarcoma
B)Fracture,with non-union
C)Osteogenic sarcoma
D)Osteoid osteoma
E)Paget's disease of bone

Answer 3

Osteogenic sarcoma

Question 4

A 55 year old former long-distance runner consulted his GP because of pain in his knee.The joint space was severely narrowed,and the pain was "intolerable".Knee replacement was done.A sample of the tissue removed is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

A)Gout
B)Osteomalacia
C)Osteoporosis
D)Osteoarthritis
E)Rheumatoid arthritis

Question 5

A 39 year old woman consulted her GP because of bilateral pain in her knees.The knees appeared swollen.The joint space was markedly decreased.Knee replacement was done,and representative tissue removed during replacement surgery is shown in the accompanying photomicrograph.

A)Gout
B)Osteomalacia
C)Osteoporosis
D)Osteoarthritis
E)Rheumatoid arthritis

Question 6

A 55 year old woman fell while touring London.She sustained a fracture of her humerus,just below the head of the humerus.The fracture was surgically repaired and sample of bone tissue was taken and sent to pathology.The sample is shown in the accompanying image with normal bone on the left for comparison.Both sections are undecalcified,and are stained with Goldner's trichrome,which stains uncalcified osteoid pink,and calcified matrix green.Which one of the following diagnoses is most likely correct?

A)Osteogenic sarcoma
B)Osteoporosis
C)Osteomalacia
D)Osteomyelitis
E)Paget's disease of bone