Deck 16: Lymphoid and Haematopoietic Systems

Question 1

A 56 year old man noticed increased fatigue,night sweats,and enlarged lymph nodes in his right axilla.He consulted his physician,a biopsy was done,and a representative section from the biopsy is shown in the accompanying photomicrograph.The right panels show staining for Bcl-2,with a normal lymph node shown in the bottom panel (GC = germinal centre,MZ = mantle zone).Which one of the following is the best diagnosis?

A)Diffuse large B cell lymphoma
B)Follicular hyperplasia
C)Follicular lymphoma
D)Hodgkin's lymphoma
E)Metastatic carcinoma

Answer 1

Follicular lymphoma

Question 2

An enlarged mesenteric lymph node was removed from the abdomen of a 64 year old man at autopsy after he died in a motor vehicle accident.A representative section is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

A)Diffuse large B cell lymphoma
B)Follicular hyperplasia
C)Follicular lymphoma
D)Hodgkin's lymphoma
E)Metastatic carcinoma

Answer 2

Metastatic carcinoma

Question 3

A 73 year old man complained to his physician about incapacitating back pain.An x-ray of the spine disclosed osteosclerotic lesions throughout the lumbar spine.A biopsy was performed,and a representative section is shown in photomicrograph "a".Photomicrograph "b" shows an immunoperoxidase stain.Antibodies against which one of the following antigens was likely used in the immunoperoxidase stain shown?

A)Albumin
B)Cytokeratin
C)Oestrogen
D)Myosin
E)Prostate specific antigen (PSA)
F)Troponin I

Answer 3

Prostate specific antigen (PSA)

Question 4

A 45 year old man with a previous history of untreated follicular lymphoma developed multiple lymph nodes that were enlarging quickly.Biopsy of one of these nodes was performed,and a representative section is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

A)Diffuse large B cell lymphoma
B)Follicular hyperplasia
C)Follicular lymphoma
D)Hodgkin's lymphoma
E)Metastatic carcinoma

Question 5

A 66 year old man saw his local physician for severe lower back pain.He had tried homeopathy and chiropractic manipulation,but nothing seemed to help.An x-ray of the spine revealed a lytic lesion at the L4 level,with collapse of the vertebral body.A spinal fusion was done,and a biopsy was sent to surgical pathology.A representative section of the biopsy is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

A)Follicular lymphoma
B)Metastatic carcinoma
C)Multiple myeloma
D)Normal bone marrow
E)Osteoporosis

Question 6

A 14 year old boy suffered from a splinter in his right finger,which became infected and inflamed.A large lymph node was found near his elbow,which his mother insisted must be removed.A representative section from the enlarged lymph node is shown at right in the accompanying photomicrograph,along with a normal lymph node that was removed at the same time.Which one of the following is the best diagnosis for the abnormal lymph node?

A)Diffuse large B cell lymphoma
B)Follicular hyperplasia
C)Follicular lymphoma
D)Hodgkin's lymphoma
E)Metastatic carcinoma