Deck 6: Misuse of Barbiturates and Barbiturate-Like Compounds

Question 1

Jorge has just discontinued use of barbiturates that he was using regularly to help him sleep.He is likely to experience _____.

A)deeper sleep than ever before
B)REM rebound
C)a lack of dreams during his sleep
D)decreased anxiety

Answer 1

REM rebound

Question 2

Bromide salts are no longer available for human use in the United States, but they continue to be used in veterinary medicine.

Answer 2

True

Question 3

Which of the following statements is most true?

A)Barbiturates continue to be a relatively popular drug of abuse.
B)Some physicians are now starting to prescribe barbiturates to avoid the paperwork associated with the prescription of other controlled compounds.
C)Barbiturates are frequently abused by professional football players for the drug's ability to control the stress that they experience in major games.
D)Barbiturates are a minor ingredient of "energy drinks" to counteract the effects of the caffeine that are their main component.

Answer 3

Some physicians are now starting to prescribe barbiturates to avoid the paperwork associated with the prescription of other controlled compounds.

Question 4

Barbituric acid has been found to be .

A)a potent hallucinogenic
B)twice as strong as diazepam as an anxiolytic compound
C)difficult to digest when consumed with foods that are highly acidic
D)biologically inactive

Question 5

Barbiturates should not be mixed with .

A)alcohol
B)MAO inhibitors
C)antihistamines
D)all of these answers are correct

Question 6

Barbiturate withdrawal is potentially life threatening and should only be attempted under the care of a physician.

Question 7

Barbiturates are helpful to people with ADHD.

Question 8

Individuals with problems with their are especially at risk of experiencing "barbiturate hangovers."

A)liver
B)kidney
C)heart
D)lungs

Question 9

When an individual overdoses on a barbiturate, they will most likely experience .

A)a stroke
B)respiratory depression
C)a manic episode
D)a seizure

Question 10

When used at higher than recommended doses, diphenhydramine can induce a state of in older adults.

A)impaired hearing
B)tardive dyskinesia
C)delirium
D)anemia

Question 11

Barbiturates are used as part of the lethal injection for the death penalty.

Question 12

Which of the following is one of the major disadvantages of paraldehyde?

A)Cardio-suppressant effects
B)Noxious taste and odor on breath
C)Staining properties on the user's teeth
D)Addictive effects (about half those of) alcohol

Question 13

The dose-dependent effect of the early anxiolytic/hypnotic drugs means they could produce in the user.

A)sedation
B)sleep
C)death
D)all of these

Question 14

At the height of their popularity .

A)more than one million pounds of barbiturate compounds were manufactured in the United States each year
B)more than one million pounds of barbiturate compounds were manufactured globally
C)barbiturates were only a laboratory curiosity for chemists, without medical application
D)barbiturates were never rejected as an agent for lethal injection

Question 15

The bromide salts were initially introduced as a .

A)treatment for insomnia, and later, when it was discovered they also have antiseizure effects, as an anticonvulsant
B)treatment for epilepsy, and later as a sedative and hypnotic
C)treatment for gastric distress caused by impure water, until it was discovered they had antiseizure effects
D)method of self-discovery by Elizabethan drug abusers

Question 16

According to your text, the first use of chloral hydrate was as .

A)pain control
B)a hypnotic agent
C)treatment for insomnia
D)a recreational drug

Question 17

Each year in the U.S., approximately of the population will experience at least transitory symptoms of insomnia.

A)33 percent
B)10 percent
C)50 percent
D)25 percent

Question 18

Which of the following statements is most accurate of the anxiety disorders?

A)They are collectively the most common form of psychiatric diagnosis.
B)They are the third most common form of psychiatric diagnosis after depression and psychotic disorders.
C)They have no relationship to the sufferers' lifestyles.
D)They are always reflected in obsessive-compulsive disorders.

Question 19

The use of barbiturates is discouraged because of .

A)their narrow therapeutic window
B)their inefficacy as a sedative or a hypnotic drug
C)their high lethality in overdose situations
D)their narrow therapeutic window and high lethality in overdose situations

Question 20

When barbiturate molecules are circulated throughout the body, the highest concentrations are found in the .

A)kidney and stomach
B)pancreas and duodenum
C)spleen and gall bladder
D)liver and brain

Question 21

According to your text, the barbiturates .

A)have a very limited role in modern medicine
B)typically exacerbate seizure disorders in patients predisposed to such conditions
C)are not contraindicated for commercial or civilian pilots
D)are the drug of choice for the aggressive treatment of GABA/NMDA inhibition disorders

Question 22

Barbiturates can _.

A)induce an amphetamine-like state of mania
B)induce respiration arrest at high dosage levels
C)increase respiration to the point at which it triggers an anxiety attack in persons with ADHD
D)not induce tolerance

Question 23

Barbiturates can when used as a hypnotic.

A)cause a paradoxical increase in theta wave activity on the EEG while the patient is asleep
B)cause an increase in "spindles" and "spikes" seen on the EEG during stage 2 sleep
C)help the user pass from stage 1 to stage 2 sleep more easily
D)suppress the duration of normal REM sleep

Question 24

Following medical convention, your text groups the barbiturates together on the basis of their .

A)degree of NMDA antagonistic action
B)ability to force the GABAa ion channel to remain open
C)ability to enhance the effects of GABAa at the receptor site
D)duration of action

Question 25

Compare and contrast the different classifications of barbiturates and note the primary criterion that distinguishes one group from another.

Question 26

Describe some of the barbiturate-like drugs that have developed since the 1950s.Why were they developed?

Question 27

Discuss the historical and current medical uses of barbiturates.Include a review of the misuse potential of these drugs.

Question 28

What are some of the potential drug interactions involving barbiturates?

Question 29

A(n) is occasionally encountered after a patient takes a barbiturate, even at recommended doses.

A)increase in heart rate to possibly dangerous levels
B)paradoxical increase in theta wave activity on the EEG while the patient is awake
C)increase in respiration to possibly fatal levels
D)paradoxical rage reaction

Question 30

Discuss some of the subjective effects of barbiturates at normal dosage levels.