Deck 22: Serology of Parasitic and Fungal Infections

Question 1

A physician wants to know if his patient who currently has a rash and fever has an active varicella-zoster virus infection.IgG against varicella-zoster virus was detected.IgM against varicella-zoster virus was not detected.What do these results mean for the patient?

A) The patient has a current varicella-zoster virus infection.
B) The patient has never had varicella-zoster virus.
C) The patient has had varicella-zoster virus in the past,but does not have it now.

Answer 1

The patient has had varicella-zoster virus in the past,but does not have it now.

Question 2

A patient has a hepatitis B profile performed and is positive for hepatitis B surface antibody only.This patient:

A) was vaccinated against hepatitis B
B) had a previous hepatitis B infection
C) is a chronic carrier of hepatitis B
D) has acute hepatitis B

Answer 2

was vaccinated against hepatitis B

Question 3

In the routine diagnosis of hepatitis C virus,which type of laboratory test should be ordered first?

A) antigen detection in liver biopsy
B) antibody detection in blood
C) viral culture of stool
D) viral culture of biliary drainage

Answer 3

antibody detection in blood

Question 4

A patient has the following serologic profile: HBsAg = negative; HBeAg = negative; anti-HBc IgM = negative; anti-HBc IgG = positive; anti-HBs = positive; anti-HBe = positive.These results indicate:

A) early acute HBV infection
B) chronic infection with HBV
C) a patient vaccinated against HBV
D) past infection with HBV

Question 5

A 36-year-old African American male presents to a free clinic with symptoms of anorexia,malaise,vomiting,abdominal pain,and mild jaundice.The patient is a known IV drug abuser.The physician orders liver function tests and an acute hepatitis serum panel.The laboratory reports the following results: anti-HAV IgM = not detected; HBsAg = not detected; anti-HBc IgM = not detected; anti-HBc total = detected; anti-HBs = detected; anti-HCV = detected.This man has:

A) acute hepatitis B
B) chronic hepatitis B
C) acute hepatitis A
D) acute hepatitis C

Question 6

A patient presents to the physician complaining of a 4-week history of fever,malaise,and irritability.The patient admits to feeling better as compared to how he felt even a week ago.The physician thinks that the patient might have had cytomegalovirus (CMV).Which of the following sets of serologic results would you see in this patient if he is recovering from CMV?

A) CMV IgM pos; CMV IgG neg
B) CMV IgM neg; CMV IgG pos
C) CMV IgM neg; CMV IgG neg

Question 7

A patient has the following hepatitis profile: anti-HAV IgM = not detected; HBsAg = not detected; anti-HBc IgM = not detected; anti-HBc total = not detected; anti-HBs = detected; anti-HCV = not detected.What is his diagnosis?

A) acute hepatitis A
B) acute hepatitis B
C) chronic hepatitis B
D) immune to hepatitis B

Question 8

A patient has detectable levels of IgG and IgM against the viral capsid antigens of Epstein-Barr virus (EBV).This patient has:

A) been infected with EBV in the past
B) an infection with HIV,too
C) a current infection with EBV
D) never had EBV

Question 9

A patient has an antibody profile for Epstein-Barr virus performed with the following results: EBVCA IgM = pos; EBVCA IgG = pos; EBV-NA = neg; EBV-EA = neg.This patient has which of the following?

A) acute EBV infection
B) convalescent EBV
C) past exposure to EBV
D) lack of EBV infection

Question 10

Serology is performed on a patient with a rash and fever with the following results: rubella IgM = positive; rubella IgG = positive; measles IgM = negative; measles IgG = positive; varicella-zoster IgM = negative; varicella-zoster IgG = negative.What is the interpretation of these results?

A) acute infection with rubella virus
B) acute infection with measles virus
C) not immune to measles or rubella viruses
D) immune to varicella-zoster virus only

Question 11

Which is the first detectable antibody in serum after infection with hepatitis B?

A) anti-HBs
B) anti-HBe
C) anti-Hbc
D) all are detectable at the same time

Question 12

A patient was diagnosed with acute hepatitis B infection 9 months ago and has follow-up testing performed today.The following results are obtained: anti-HAV IgM = not detected; HBsAg = not detected; anti-HBc IgM = not detected; anti-HBc total = detected; anti-HBs = detected; anti-HCV = not detected.What is the diagnosis now?

A) acute hepatitis B
B) chronic hepatitis B
C) chronic hepatitis C
D) convalescent hepatitis B

Question 13

A patient has the following hepatitis profile: anti-HAV IgM = not detected; HBsAg = detected; anti-HBc IgM = detected; anti-HBc total = detected; anti-HBs = not detected; anti-HCV = not detected.What is his diagnosis?

A) acute hepatitis A
B) acute hepatitis B
C) acute hepatitis C
D) chronic hepatitis B
E) immune to hepatitis B

Question 14

In the routine diagnosis of rubella virus,which type of laboratory test should be ordered first?

A) antigen detection
B) antibody detection
C) viral culture

Question 15

Serologic test results indicating that a patient is a chronic carrier of hepatitis B would be which of the following?

A) HBsAb positive; HBsAg negative
B) HBcAb and HBsAb positive
C) HBsAb negative; HBsAg positive for 12 months
D) HBeAb and HBeAg negative

Question 16

Which of the following positive antibody tests may be an indication of recent vaccination or early primary infection for rubella in a patient with no clinical symptoms?

A) only IgG positive
B) only IgM positive
C) both IgG and IgA antibodies positive
D) fourfold rise in titer for IgG

Question 17

A 14-year-old boy presents to the physician complaining of sore throat,fatigue,and fever for the last week.A monotest was performed and was reported as positive.This boy has:

A) infectious mononucleosis
B) streptococcal pharyngitis
C) acute glomerulonephritis
D) common cold

Question 18

The causative agent of infectious mononucleosis is

A) Streptococcus pyogenes
B) Staphylococcus aureus
C) Epstein-Barr virus
D) HIV

Question 19

A patient has the following hepatitis profile after presenting with jaundice,nausea,and vomiting: anti-HAV IgM = detected; HBsAg = not detected; anti-HBc IgM = not detected; anti-HBc total = detected; anti-HBs = not detected; anti-HCV = not detected.What is his diagnosis?

A) acute hepatitis A
B) acute hepatitis B
C) acute hepatitis C
D) chronic hepatitis B

Question 20

In infectious mononucleosis,which of the following would be detectable earliest in the infection,thereby indicating a current infection?

A) anti-EA-IgG
B) anti-EBNA
C) anti-VCA-IgM
D) anti-VCA-IgG

Question 21

The Paul Bunnell test for mononucleosis would detect which of the following?

A) heterophile antibody for mononucleosis
B) Forssman antibody
C) serum sickness antibody
D) any of the above

Question 22

A positive rubella titer in a healthy,nonpregnant 22-year-old female most likely indicates which of the following?

A) immunity after administration of the vaccine
B) current presence of the disease
C) no immunity
D) possibility of congenital rubella

Question 23

A patient with infectious mononucleosis would have what outstanding feature in the hematology evaluation?

A) decreased total white blood cells
B) presence of atypical lymphocytes
C) increased percentage of eosinophils
D) absence of neutrophils

Question 24

All of the following are characteristic of the Epstein Barr virus EXCEPT:

A) latent virus
B) DNA virus
C) cause of infectious mono
D) invades T cells

Question 25

In the slide test for infectious mononucleosis,what purpose do the guinea pig kidney cells serve?

A) absorb out mono antibody
B) absorb out Forssman antibody
C) enhance the agglutination reaction
D) serve as a positive control

Question 26

A 17-year-old female with suspected mononucleosis tested negative for heterophile antibody using the slide agglutination monotest.Her serum was sent to a reference lab,and the following results were obtained: negative for anti-VCA,positive for EA.What do these results suggest?

A) She does not have mononucleosis.
B) She is a healthy carrier of the virus.
C) Mononucleosis has been reactivated.
D) She is in the early stages of the disease.

Question 27

A physician suspects that his patient has infectious mononucleosis.Heterophile antibody tests are negative.Serological testing for Epstein-Barr virus was performed with the following results obtained: EBV VCA IgM = neg; EBV VCA IgG = neg; EBV-EA = neg; EBV-NA = neg.What is this person's status with regards to EBV?

A) acute EBV
B) convalescent EBV
C) never infected with EBV
D) past exposure to EBV

Question 28

A patient has the following EBV antibody profile: EBVCA IgM = neg; EBVCA IgG = pos; EBV-EA IgG = pos; EBV-NA IgG = pos.Which of the following is the correct interpretation of these data?

A) never infected with EBV
B) acute infection with EBV
C) recent convalescence from EBV
D) long-ago past infection with EBV

Question 29

In a slide agglutination test for mononucleosis using guinea pig kidney and horse red blood cells,if there is no agglutination when the horse red cells are added,what conclusion can be drawn?

A) It is positive for mononucleosis.
B) It is negative for mononucleosis.
C) It is positive for Forssman antibody.
D) It indicates RF antibody.