Deck 17: Transplantation Immunology

Question 1

Which term applies to the type of graft rejection that begins within a few weeks or months after transplantation of an organ and is due to CD8 reactive T cells?

A) acute rejection
B) hyperacute rejection
C) chronic rejection
D) accelerated rejection

Answer 1

chronic rejection

Question 2

Graft-versus-host disease results under which conditions?

A) when immunocompetent cells are placed in an immunocompromised host
B) when immunodeficient cells are placed in an immunocompetent host
C) any time tissue is not exactly matched in a transplant
D) only when adult cells are transplanted into a baby

Answer 2

when immunocompetent cells are placed in an immunocompromised host

Question 3

Transplantation of an individual's skin from one place to another is an example of a(n):

A) autograft
B) allograft
C) xenograft
D) heterograft

Answer 3

autograft

Question 4

A 25- year-old female is in kidney failure and needs a transplant.She is A positive and HLA A1A3/B5B7/C2C9/DR4DR8.Which of the following donors would be the best match?

A) her brother,who is B positive and HLA A1A3/B7B5/C2C9/DR8DR4
B) her sister,who is A positive and HLA A3A4/B7B9/C2C3/DR4DR7
C) her mother,who is AB positive and HLA A1A4/B9B5/C9C3/DR8DR7
D) an unrelated donor who is A positive and HLA A6A3/B5B7/C3C10/DR2DR9

Question 5

When foreign HLA antigens are presented by antigen-presenting cells to T cells,this is known as:

A) direct allorecognition
B) indirect allorecognition
C) minor histocompatibility recognition
D) acute rejection

Question 6

When a complement-dependent cytotoxicity test was performed using standard antibodies to HLA A1,A3,B2,and B11,the following microscopic results were obtained: a majority of blue cells were seen with anti-A1,A3,and B11.Based on these results,what is the phenotype of the donor cells?

A) HLA A1,B11
B) HLA B2 only
C) HLA A1,A3,B11
D) cannot be determined from these results

Question 7

Which test would be best to determine the actual genotype in an HLA matching?

A) enzyme-linked immunosorbent assay
B) serological testing
C) polymerase chain reaction
D) flow cytometry

Question 8

Which antigens are most important in matching for tissue transplants?

A) HLA A and B
B) blood group antigens A or B
C) HLA DR1 and DQ1
D) all of the above

Question 9

The type of rejection that occurs within minutes to hours due to preformed antibody is known as:

A) delayed rejection
B) chronic rejection
C) accelerated rejection
D) hyperacute rejection