Deck 5: Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Question 1

What is the diameter of a macrocyte?

A) 4-6 µm
B) 6-8 µm
C) 9-12 µm
D) 3-5 µm
E) None of the above

Answer 1

9-12 µm

Question 2

Target cells may be found in which of the following conditions?

A) Thalassemia
B) Liver disease
C) Hemoglobin C disease
D) Sickle cell anemia
E) All of the above

Answer 2

All of the above

Question 3

A microcyte is defined as having a diameter less than which value?

A) 8 µm
B) 7 µm
C) 10 µm
D) 12 µm
E) None of the above

Answer 3

7 µm

Question 4

A patient diagnosed with anemia of chronic disorder would demonstrate:

A) Macrocytosis
B) Microcytosis
C) Normocytosis
D) Sickled cells
E) None of the above

Question 5

Which distinctive property is characteristic of a spherocyte?

A) Hypochromia
B) Increased surface area-to-volume ratio
C) Decreased surface area-to-volume ratio
D) Visible central pallor
E) None of the above

Question 6

The grading of "slight" anisocytosis and poikilocytosis would indicate what percentage of RBCs would differ from normal red cells?

A) 5-10%
B) 25-50%
C) 50-75%
D) >75%
E) 10-25%

Question 7

A patient diagnosed with autoimmune hemolytic anemia may have a blood smear demonstrating:

A) Cabot rings
B) Spherocytes
C) Target cells
D) Stomatocytes
E) None of the above

Question 8

A 2+ grading for poikilocytosis would indicate what percentage of RBCs would differ from normal red cells?

A) 5-10%
B) 25-50%
C) 50-75%
D) >75%
E) 10-25%

Question 9

A drepanocyte is another name for which red cell?

A) Spherocyte
B) Sickle cell
C) Ovalocyte
D) Stomatocyte
E) Target cell

Question 10

Codocyte is another name for which type of red cell?

A) Drepanocyte
B) Ovalocyte
C) Sickle cell
D) Spherocyte
E) Target cells

Question 11

Hypochromia is defined as any red cell having a central area of pallor of greater than which value?

A) 1 µm
B) 2 µm
C) 3 µm
D) 5 µm
E) Any of the above

Question 12

What is the average diameter of a mature erythrocyte?

A) 8-10 µm
B) 3-5 µm
C) 7-8 µm
D) 4-6 µm
E) None of the above

Question 13

Evaluation of macrocytosis on a peripheral blood smear should include:

A) Shape
B) Presence of inclusions
C) Color
D) All of the above
E) None of the above

Question 14

The mature erythrocyte, upon maturity, passes from a:

A) Nucleated to non-nucleated state
B) Non-nucleated to nucleated state
C) Non-basophilic to basophilic state
D) Granulated to nongranulated cytoplasm
E) None of the above

Question 15

What might cause a microcytosis?

A) Decreased globin synthesis
B) Decreased hemoglobin synthesis
C) Ineffective iron utilization
D) Deficiency of iron
E) All of the above

Question 16

As cholesterol accumulates in the plasma, as in the case of patients with liver dysfunction, the cells that are observed in the blood smear are the:

A) Spherocytes
B) Target cells
C) Ovalocytes
D) Stomatocytes
E) None of the above

Question 17

A normal size red cell with a slit-like area of central pallor is called a:

A) Drepanocyte
B) Ovalocyte
C) Sickle cell
D) Stomatocyte
E) Target cell

Question 18

A 4+ grading for anisocytosis would indicate what percentage of red blood cells (RBCs) would differ from the normal red cells?

A) 5-10%
B) 25-50%
C) 50-75%
D) >75%
E) 10-25%

Question 19

What is the primary function of hemoglobin?

A) To maintain cell shape
B) To store iron
C) To maintain cell deformity
D) To carry oxygen
E) None of the above

Question 20

All of the following are proposed mechanisms of macrocytosis except:

A) Impaired DNA synthesis
B) Impaired RNA synthesis
C) Accelerated erythropoiesis
D) Increased membrane cholesterol and lecithin
E) None of the above

Question 21

Heinz bodies are a result of:

A) Denatured hemoglobin
B) Residual RNA
C) Residual DNA
D) Hemoglobin H
E) None of the above

Question 22

Rouleaux formation is the result of:

A) Increased fibrinogen
B) Decreased fibrinogen
C) Decreased globulin
D) Post-splenectomy
E) None of the above

Question 23

What is the size of a normal platelet?

A) 6-7 m
B) 4-6 m
C) 7-8 m
D) 2-4 m
E) 0.5-1 m

Question 24

What factor affects the red cell's tendency to sickle in sickle cell anemia?

A) High oxygen tension
B) Low oxygen tension
C) Irradiation
D) Infection
E) None of the above

Question 25

Leukocytosis commonly refers to an increase in peripheral blood white blood cell (WBC) counts of greater than what value?

A) 5000 cells/L
B) 1000 cells/L
C) 10,000 cells/L
D) 8000 cells/L
E) 4000 cells/L

Question 26

What hematologic condition is associated with the appearance of Heinz bodies?

A) Sickle cell anemia
B) Glucose 6-phosphate dehydrogenase (G6PD) deficiency
C) Liver disease
D) Aplastic anemia
E) None of the above

Question 27

A tear-drop cell is formed as a result of:

A) Red cell fragmentation
B) Pinching off a red cell inclusion
C) Increased lipids in red cell membrane
D) All of the above
E) None of the above

Question 28

An acanthocyte can be described as containing:

A) 3-12 spicules of even length
B) 3-12 spicules of uneven length
C) 2 spicules of equal length
D) 2 spicules of unequal length
E) None of the above

Question 29

A person diagnosed with lead poisoning may demonstrate:

A) Basophilic stippling
B) Cabot rings
C) Tear drop cells
D) Howell-Jolly bodies
E) None of the above