Deck 18: Fibrinogen, Thrombin, and the Fibrinolytic System

Question 1

All of the following are functions of thrombin except:

A) Initiating the platelet release reaction
B) Simulating platelets to product PGI₂
C) Activating factors V and VIII
D) Activating thromboplastin

Answer 1

D

Question 2

The D-dimer test measures:

A) Fibrinogen deposition
B) Fibrinogen degradation
C) Fibrin degradation
D) Fibrin deposition

Answer 2

D

Question 3

A prolonged thrombin time and a normal reptilase time is indicative of:

A) Aspirin therapy
B) FDPs
C) Heparin therapy
D) Warfarin therapy

Answer 3

C

Question 4

A patient with DIC will have the following coagulation test results except:

A) An increased PT/INR
B) An increased aPTT
C) An increased fibrinogen
D) An increased D-dimer

Question 5

An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood?

A) D-dimers
B) Alpha-2-antiplasmin
C) Protein C
D) Plasmin

Question 6

The best component to use for patients with afibrinogenemia is:

A) Whole blood
B) Fresh frozen plasma
C) Tissue plasminogen activator
D) Factor XIII

Question 7

Which of these are byproducts of fibrinolysis?

A) Fibrin degradation products and D-dimers
B) Fibrinopeptides A and B
C) Streptokinase and urokinase
D) Alpha 2 antiplasmin

Question 8

D-dimers may be elevated in which of the following?

A) Sickle cell disease
B) Glanzmann's thrombasthenia
C) Deep vein thrombosis
D) Bernard-Soulier syndrome

Question 9

Prothrombin can only be converted to thrombin by the action of factor X, factor V, platelet factor 3, and:

A) Factor II
B) Fibrinogen
C) Calcium
D) Phosphorus

Question 10

A primary inhibitor of the fibrinolytic system is:

A) Alpha 2 antiplasmin
B) Alpha 2 macroglobulin
C) Antithrombin
D) Protein C

Question 11

The process of fibrin degradation is called ______and is controlled by the enzyme _________.

A) fibrination, plasmin
B) fibrinolysis, plasmin
C) fibrination, protease
D) fibrinolysis, protease

Question 12

Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure:

A) Less than 20 µg/mL
B) Less than 40 µg/mL
C) Less than 75 µg/mL
D) Less than 100 µg/mL

Question 13

The substrate upon which the coagulation cascade is centered is:

A) Thrombin
B) Vitamin K
C) Fibrinogen
D) Fibrin

Question 14

The reference range for a thrombin time is:

A) 20 to 40 seconds
B) 100 to 120 seconds
C) 40 to 60 seconds
D) 11 to 15 seconds

Question 15

The reference range for fibrinogen is:

A) 100 to 200 mg/dL
B) 200 to 400 mg/dL
C) 400 to 600 mg/dL
D) 600 to 750 mg/dL

Question 16

Plasmin causes the inactivation of factors:

A) V, VII, X, XI
B) V, VIII, XI, XII
C) VII, VIII, XI, XII
D) X, XI, XII, XIII

Question 17

Obstetrical complications like retained placenta or abruptio placenta are leading causes of:

A) Thrombosis
B) DIC
C) ITP
D) TTP

Question 18

Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of:

A) 0 to 20 mg/dL
B) 20 to 100 mg/dL
C) 50 to 150 mg/dL
D) 100 to 200 mg/dL

Question 19

Which of the following hematology disorders will likely trigger an episode of DIC?

A) Sickle cell disease
B) Iron deficiency anemia
C) Idiopathic thrombocythemia
D) Acute progranulocytic leukemia

Question 20

Primary fibrinolysis is a disorder closely related to DIC.All of the coagulation profile assays are the same as that for DIC with the exception of the:

A) D-dimer level, which is increased
B) Fibrinogen level, which is decreased
C) Platelet count, which is normal
D) PT/INR, which is increased