Deck 19: Introduction to Thrombosis and Anticoagulant Therapy

Question 1

Coumadin acts in such a way that it:

A) Alters the synthesis of vitamin Kdependent factors
B) Reduces the circulating level of factors III and V
C) Reduces the circulating level of factor I
D) Cleaves carboxyreductase to generate glutamic acid

Answer 1

A

Question 2

All of the following are naturally occurring thrombin inhibitors except:

A) AT
B) Prothrombin cofactor II
C) Protein C
D) Plasmin

Answer 2

D

Question 3

The lupus anticoagulant is directed against:

A) Factor VIII
B) Factor X
C) Factor IX
D) Phospholipids

Answer 3

D

Question 4

The target therapeutic range for an INR in patients with thromboembolic disease is:

A) 1 to 2
B) 1.5 to 2.5
C) 2 to 3
D) 2 to 2.5

Question 5

Drug alternatives for patients with heparin-induced thrombocytopenia include:

A) Danaparoid
B) Warfarin
C) Streptokinase
D) Aspirin

Question 6

The international normalized ratio (INR) is useful in:

A) The detection of coagulation factor deficiencies
B) Monitoring heparin therapy
C) The detection of inhibitors
D) Monitoring Coumadin therapy

Question 7

Protein C is activated by which of the following?

A) Heparin cofactor II
B) Factor VIII a
C) Antithrombin
D) Protein S

Question 8

All of the following statements describe factor V Leiden except:

A) It is a cause of activated protein C resistance.
B) It is associated with thrombocytopenia.
C) It is associated with increased risk of thrombosis.
D) Is an inherited disorder.

Question 9

The most common tests used to detect Lupus anticoagulants include all of the following except:

A) aPTT
B) Kaolin clotting time
C) PT/INR
D) Dilute Russell viper venom test

Question 10

Antithrombin inhibits all of the following factors except:

A) II a
B) VII a
C) IX a
D) XI a

Question 11

Heparin-induced thrombocytopenia (HIT) usually:

A) Occurs as a result of protein C deficiency
B) Will show an increase in platelets
C) Occurs 5 to 14 days after heparin therapy
D) Occurs only in males

Question 12

Arterial thrombosis is associated with:

A) Slow blood flow
B) Impairment of the fibrinolytic system
C) Atherosclerosis
D) A deficiency of physiologic inhibitors

Question 13

Factor VIII inhibitors:

A) Are associated with thrombosis
B) Are associated with decreased fibrinogen levels
C) Are usually time and temperature dependent
D) Are corrected with the addition of normal plasma

Question 14

Primary hemostasis refers to the process by which:

A) The platelet plug is formed
B) A cross-linked fibrin clot is formed
C) Fibrin degradation products are generated
D) None of the above

Question 15

What therapy may be used for a patient with hemophilia A who is bleeding and has a low titer of factor VIII inhibitor?

A) Fresh frozen plasma
B) Porcine factor VIII
C) Antithrombin concentrate
D) High-dosage factor VIII concentrate

Question 16

All of the following statements are true regarding Coumadin except:

A) It is a vitamin K antagonist.
B) It needs antithrombin as a cofactor.
C) PT is used to monitor its dosage.
D) It is not recommended for pregnant and lactating women.

Question 17

Which of the following PT results would most likely be seen in a patient who is on Coumadin and is stable?

A) Approximately 26 seconds
B) Approximately 13 seconds
C) Approximately 40 seconds
D) Approximately 60 seconds

Question 18

Heparin therapy is monitored best by performing routine:

A) PT/INRs
B) anti-factor Xa
C) Fibrinogen levels
D) Bleeding time tests

Question 19

Heparin:

A) Inhibits PF3
B) Inhibits thrombin
C) Degrades antithrombin
D) Complexes with protein C

Question 20

The primary role of plasmin is:

A) Platelet aggregation
B) Fibrin breakdown
C) Prevention of thrombotic events
D) Coagulation inhibition