Deck 17: Defects of Plasma Clotting Factors

Question 1

Clotting factors must be present at a minimum of which percentage for hemostasis to be achieved?

A) 20%
B) 30%
C) 50%
D) 75%

Answer 1

B

Question 2

Which result will be within reference range in a patient with dysfibrinogenemia?

A) Thrombin time
B) Activated partial thromboplastin time
C) Immunologic fibrinogen level
D) Protein electrophoresis

Answer 2

C

Question 3

The following laboratory results have been obtained for a 40-year-old woman: PT = 20 seconds (reference range is 11 to 15 seconds), aPTT = 50 seconds (reference range is 22 to 40 seconds), and thrombin time = 18 seconds (reference range is 11 to 15 seconds).What factor deficiency is most likely?

A) Factor VII deficiency
B) Factor VIII deficiency
C) Factor X deficiency
D) Factor XIII deficiency

Answer 3

C

Question 4

Which of the following is the most useful in differentiating hemophilia A from hemophilia B?

A) A familial pattern of inheritance
B) Patient's history
C) Activated partial thromboplastin time
D) Factor assays

Question 5

Which of the following assays will be abnormal with hemophilia A?

A) Platelet count
B) Bleeding time
C) PT
D) aPTT

Question 6

A prolonged aPTT is corrected with factor VIIIdeficient plasma but not with factor IXdeficient plasma.What factor is deficient?

A) IX
B) XIII
C) V
D) X

Question 7

A man with hemophilia A and an unaffected female can produce a:

A) Female carrier
B) Male carrier
C) Male with hemophilia A
D) Normal female

Question 8

Factor XI deficiency is also known as:

A) Christmas disease
B) Hemophilia A
C) Hemophilia C
D) Fitzgerald factor deficiency

Question 9

Long-term antibiotic therapy is a cause of bleeding because it disrupts:

A) Vitamin K synthesis
B) Contact activation
C) Platelet aggregation
D) Fibrinolytic activity

Question 10

Christmas disease is another name for:

A) Hemophilia A
B) Hemophilia B
C) von Willebrand's disease
D) Factor VII deficiency

Question 11

Which platelet response(s) is usually associated with hemophilia A?

A) Defective ADP release; normal response to ADP
B) Decreased amount of ADP in platelets
C) Absent aggregation to epinephrine, ADP, and collagen
D) Normal platelet aggregation

Question 12

Treatment of patients with factor II, VII, or X deficiency consists of:

A) Administration of prothrombin complex concentrate
B) Administration of cryoprecipitate
C) Administration of FFP
D) Administration of whole blood

Question 13

Keloid scar formation is most commonly associated with:

A) Factor VIII deficiency
B) Factor IX deficiency
C) Factor XII deficiency
D) Factor XIII deficiency

Question 14

The only clotting factor not synthesized exclusively by the liver is:

A) Factor V
B) Factor VII
C) Factor VIII
D) Factor IX

Question 15

The treatment of choice for hemophilia A individuals is:

A) Cryoprecipitate
B) Factor VIII concentrate
C) Prothrombin complex
D) DDAVP

Question 16

Hemophilia B is best treated with:

A) A mixture of factors II, VII, IX, and X
B) Factor X concentrate
C) Factor VIII concentrate
D) Vitamin K

Question 17

Factor assays measure the percentage of activity of a given factor by mixing the patient's plasma with:

A) Normal plasma
B) Adsorbed plasma
C) Factor-deficient plasma
D) Factor-specific plasma

Question 18

Which of the following is the most prevalent inherited bleeding disorder?

A) von Willebrand disease
B) Hemophilia A
C) Factor VII deficiency
D) Factor XII deficiency

Question 19

Factor V Leiden is a genetic mutation of:

A) Factor IV
B) Factor V
C) The prothrombin molecule
D) Hemophilia A

Question 20

All of the following may lead to deficiencies of clotting factors except:

A) Renal disease
B) Liver disease
C) Autoimmune disease
D) Cardiovascular disease