Deck 10: Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Question 1

Opsonization of foreign bodies is defined as:

A) Preparing a foreign body for phagocytosis
B) Degranulation of neutrophils
C) Fusion of cytoplasmic granules
D) Bacteriocidal activity

Answer 1

A

Question 2

A 17-year-old boy is admitted to the hospital with a fever of unknown origin.His WBC count is 20.0  10⁹/L.All of the following can be seen on his peripheral smear except:

A) Toxic granulation
B) Reactive monocytes
C) Increased band neutrophils
D) Dohle bodies

Answer 2

B

Question 3

All of the following are lipid storage syndromes/diseases except:

A) Gaucher's disease
B) Tay-Sachs disease
C) Chediak-Higashi syndrome
D) Niemann-Pick disease

Answer 3

C

Question 4

A patient who presents with a low white cell count, thrombocytopenia, elevated liver enzymes, and mulberry-like inclusions in the granulocytes is most likely suffering from:

A) May-Hegglin anomaly
B) Chediak-Higashi anomaly
C) Human ehrlichiosis
D) Alder's anomaly

Question 5

Infectious mononucleosis is caused by the EBV virus, which infects B lymphocytes.

Question 6

All of the following are mechanisms by which neutropenia is usually produced except:

A) Decreased production by the bone marrow
B) Impaired release from the bone marrow to the blood
C) Increased destruction
D) Bacterial infection

Question 7

Dohle bodies consist of:

A) DNA
B) Primary granules
C) Ribosomes RNA
D) Lipid deposits

Question 8

Toxic vacuolization occurs most frequently in:

A) Neutrophils
B) Monocytes
C) Lymphocytes
D) Erythrocytes

Question 9

Pelger-Huët anomaly is characterized mainly by:

A) Neutrophils with gray-green granules
B) Lipid depositions in the cytoplasm
C) Giant platelets
D) Hyposegmentation of the nucleus in the neutrophils

Question 10

In which white cell disorder will you see gray-green cytoplasmic granules in the neutrophils?

A) May-Hegglin anomaly
B) Alder's anomaly
C) Pelger-Huët anomaly
D) Chediak-Higashi syndrome

Question 11

A patient who has a persist leukocytosis, Dohle bodies, and an elevated LAP score most likely has a (an):

A) Leukemoid reaction
B) Pelger-Huët anomaly
C) Parasitic infection
D) HIV infection

Question 12

Toxic granulation in neutrophils is a direct result of:

A) Cytokine production
B) Enhanced lysosome enzyme production
C) Toxic granulation
D) Ehrlichia infection

Question 13

The normal ratio of CD4 to CD8 lymphocytes is:

A) 1:2
B) 1:1
C) 2:1
D) 4:1

Question 14

Name the cell at the tip of the pointer (Wright stain).

A) Spherocyte
B) Target cell
C) Platelet
D) Acanthocyte

Question 15

In which white cell disorder will you see prominent deposition of granules in every cell line?

A) May-Hegglin anomaly
B) Alder's anomaly
C) Pelger-Huët anomaly
D) Chediak-Higashi syndrome

Question 16

A typical blood picture in infectious mononucleosis is an absolute:

A) Lymphocytosis and anemia with many reactive lymphocytes
B) Lymphocytosis without anemia and many reactive lymphocytes
C) Monocytosis and anemia with many atypical monocytes
D) Monocytosis without anemia and many atypical monocytes

Question 17

The best corrective action for a patient who exhibits platelet satellitism on peripheral blood smear is to:

A) Make a duplicate slide and see if this phenomenon disappears
B) Warm the tube of blood
C) Redraw the sample in sodium citrate
D) Vortex the sample of blood

Question 18

Which of the following statements is common to most lipid storage diseases?

A) They are caused by an amino acid substitution.
B) They are caused by a DNA synthetic defect.
C) They are caused by a missing metabolic enzyme.
D) They are caused by the invasion of a rickettsial organism.

Question 19

Which of the following is an unusual complication that may occur in infectious mononucleosis?

A) Splenic infarctions
B) Dactylitis
C) Hemolytic anemia
D) Giant platelets

Question 20

An autosomal disorder that manifests itself with large lysosomal inclusions, recurring infections, and albinism is:

A) Chediak-Higashi
B) Pelger-Huët
C) May-Hegglin
D) Alder-Reilly