Deck 7: Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

Question 1

Red cells that are rigid, provide resistance to malaria, and spoon shaped are termed:

A) Burr cells from kidney disease
B) Spherocytes from hereditary spherocytes
C) Ovalocytes from Southeast Asian ovalocytosis
D) Sickle cells from sickle cell disease

Answer 1

C

Question 2

Spherocytes do not function well in the splenic environment because the:

A) Osmotic environment of the spherocyte is impaired
B) Immunologic function of the spleen is impaired
C) Reservoir function is impaired
D) Filtration function of the spleen is compromised

Answer 2

A

Question 3

The cell at the tip of the pointer is referred to as a:

A) Stomatocyte
B) Target cell
C) Normal erythrocyte
D) Spherocyte

Answer 3

D

Question 4

Individuals with Fanconi's anemia characteristically will have:

A) Intravascular hemolysis
B) Increased Hgb F
C) Ringed sideroblastics
D) Thrombocytosis

Question 5

Cholelithiasis is a frequent complication of patients with hereditary spherocytosis because:

A) Spherocytes are an abnormal red cell morphology
B) The gallbladder does not function well in this condition
C) Continued hemolysis in this condition causes gallstones to form
D) The filtration function of the spleen is overworked

Question 6

The inclusions pictured below are seen with supravital staining only.These inclusions are most likely:

A) Heinz bodies
B) Howell-Jolly bodies
C) Pappenheimer bodies
D) Due to stain contamination

Question 7

The inability of the red blood cell to generate ATP for membrane function is most closely associated with:

A) Pyruvate kinase deficiency
B) G6PD deficiency
C) Fanconi's anemia
D) Congenital hemolytic anemia

Question 8

An osmotic fragility test is performed on a patient's sample.Initial hemolysis occurs at 0.75% NaCl and complete hemolysis occurs at 0.50% NaCl.These results are indicative of which of the following disorders?

A) Sickle cell anemia
B) Hgb C disease
C) Thalassemia major
D) Hereditary spherocytosis

Question 9

In hereditary spherocytosis, the reticulocyte count will typically be:

A) Less than 0.5%
B) 0.5% to 1.5%
C) 3% to 10%
D) Greater than 10%

Question 10

Spherocytes differ from normal cells in all of the following ways except:

A) Decreased surface-to-volume ratio
B) Decreased central pallor
C) Decreased resistance to hypotonic saline
D) Increased deformability

Question 11

Which of the following is most closely associated with G6PD deficiency?

A) Continuous intravascular hemolysis occurs.
B) G6PD is a sex linked inherited disease.
C) Splenectomy is commonly done to control symptoms.
D) The majority of the erythrocytes in these individuals are microcytic.

Question 12

One of the least severe clinical manifestations of G6PD deficiency is:

A) Acute hemolytic anemia
B) Favism
C) Neonatal jaundice
D) Congenital non-spherocytic hemolytic anemia

Question 13

Spherocytes may enter the circulation via a variety of mechanisms.To distinguish the CBC of a patient with hereditary spherocytosis from the CBC of a patient with autoimmune hemolytic anemia, one could use the:

A) MCHC
B) Hematocrit
C) MCH
D) MCV

Question 14

The deficit of which of these is most closely associated with Southeast Asian ovalocytosis?

A) Spectrin
B) Ankyrin
C) Molecular band 3
D) G6PD

Question 15

Which of the following red blood cell membrane defects results in an increased sensitivity to complement lysis?

A) Cold agglutinin syndrome
B) Paroxysmal nocturnal hemoglobinemia
C) Diamond Blackfan anemia
D) Hereditary spherocytosis

Question 16

The cells circled below show an eccentric "puddling" of their hemoglobin contents.This is most closely associated with:

A) Stomatocytosis
B) Xerocytosis
C) G6PD deficiency
D) Pyruvate kinase deficiency

Question 17

Bite cells are formed from:

A) The spleen "pitting" out Heinz bodies
B) Third-degree burns
C) Spectrin deficiency
D) G6PD deficiency

Question 18

The cell pictured at the tip of the pointer is known as a (an):

A) Sickle cell
B) Acanthocyte
C) Bite cell
D) Stomatocyte

Question 19

The RBC inclusions that are composed of denatured hemoglobin are called:

A) Pappenheimer bodies
B) Howell-Jolly bodies
C) Heinz bodies
D) Siderotic granules

Question 20

An anemia that manifests as decreased marrow cellularity, pancytopenia, and a reticulocytopenia is appropriately termed:

A) Megaloblastic anemia
B) Aplastic anemia
C) Sideroblastic anemia
D) Iron deficiency anemia