Deck 3: Signal Transduction, membrane Receptors, second Messengers, and Regulation of Gene Expression

Question 1

A typical flow of information in a signal transduction pathway would be which of the following?

A)Receptor $\rightarrow$ G protein $\rightarrow$ second messenger $\rightarrow$ biological response
B)Hormone $\rightarrow$ second messenger $\rightarrow$ G protein-coupled receptor (GPCR) $\rightarrow$ biological response
C)Hormone $\rightarrow$ second messenger $\rightarrow$ GPCR
D)Hormone $\rightarrow$ receptor $\rightarrow$ second messenger $\rightarrow$ GPCR $\rightarrow$ biological response
E)GPCR $\rightarrow$ second messenger $\rightarrow$ biological response

Answer 1

Receptor $\rightarrow$ G protein $\rightarrow$ second messenger $\rightarrow$ biological response

Question 2

Molecules that are produced by cells and act locally on other cells are called:

A)Steroid hormones.
B)Receptors.
C)Paracrine hormones.
D)Phosphatases.
E)Iodothyronines.

Answer 2

C

Question 3

The negative side effects of nonsteroidal antiinflammatory drugs (NSAIDs)on the cardiovascular system are mediated by inhibition of which enzyme?

A)Cyclooxygenase-1 (COX1)
B) $\gamma$ -Secretase
C)Presenilin 1
D)Cyclooxygenase-2 (COX2)
E)Adenylate cyclase

Answer 3

Cyclooxygenase-2 (COX2)

Question 4

In the following list,which drug is correctly used to treat the disease listed?

A) $\beta$ -Adrenergic receptor agonists with depression
B)Fluoxetine (Prozac)with low blood pressure
C)Trastuzumab (Herceptin)with metastatic HYPERLINK "http://en.wikipedia.org/wiki/Colorectal_cancer"colorectal cancer
D)Sildenafil (Viagra)with pulmonary arterial hypertension
E)Cetuximab (Erbitux)and bevacizumab (Avastin)with metastatic breast cancer