Genetics: Analysis and Principles 4th Edition by Robert Brooker

Exercise 1

A person with a rare genetic disease has a sample of her chromosomes subjected to in situ hybridization using a probe that is known to recognize band p11 on chromosome 7. Even though her chromosomes look cytologically normal, the probe does not bind to this person's chromosomes. How would you explain these results How would you use this information to positionally clone the gene that is related to this disease