Genetics: Analysis and Principles 5th Edition by Robert Brooker

Exercise 55

The codon change (Gly-12 to Val-12) in human ras H that converts it to oncogenic ras H has been associated with many types of cancers. For this reason, researchers would like to develop drugs to inhibit oncogenic ras H. Based on your molecular understanding of the Ras protein, what types of drugs might you develop In other words, what would be the structure of the drugs, and how would they inhibit Ras protein How would you test the efficacy of the drugs What might be some side effects