Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

Exercise 6

Calculating K eq and G° for coupled reactions
For the process A B, K eq (AB) is 0.02 at 37ºC. For the process B C, K eq (BC) is 1000 at 37ºC.
a. Determine K eq (AC), the equilibrium constant for the overall process A C from K eq (AB) and K eq (BC).
b. Determine standard state free energy changes for all three processes, and use G°(AC) to determine K eq (AC). Make sure that this value agrees with that determined in part a, of this problem.