Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

Exercise 10

Calculate the free energy change for synthesis of a polynucleotide
(Integrates with Chapter 3) The synthesis of RNA can be summarized by the reaction:
n NTP * (NMP)n + n PPi
What is the Gº'overall for synthesis of an RNA molecule 100 nucleotides in length, assuming the Gº' for transfer of an NMP from an NTP to the 3'-OH of polynucleotide chain is the same as the Gº' for transfer of an NMP from an NTP to H20 (Use data given in Table 3.3.)