Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

Exercise 4

The number of clones needed to screen a yeast genomic library at 99% confidence
Yeast (Saccharomyces cerevisiae) has a genome size of 1.21 x 10 7 bp. If a genomic library of yeast DNA was constructed in a bacteriophage vector capable of carrying 16 kbp inserts, how many individual clones would have to be screened to have a 99% probability of finding a particular fragment