Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

Exercise 16

Figure 12.1 shows restriction endonuclease sites for the plasmid pBR322. You want to clone a
DNA fragment and select for it in transformed bacteria by using resistance to tetracycline and sensitivity to ampicillin as a way of identifying the recombinant plasmid. What restriction endonucleases might be useful for this purpose