Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

Exercise 4

Deriving an expression for enzymatic rate acceleration
Based on the reaction scheme shown below, derive an expression for k e /k u , the ratio of the rate constants for the catalyzed and uncatalyzed reactions, respectively, in terms of the free energies of activation for the catalyzed ( G ‡ e ) and the uncatalyzed ( G ‡ u ) reactions.